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Co-Cr-Mo-Cu alloys for clinical implants with osteogenic effect by increasing bone induction, formation and development in a rabbit model

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Burns & Trauma 2020年第1期8卷 1-13页

作者： Jingzhu Duan Yang Yang Erlin Zhang Huan Wang Department of Orthopaedic Shengjing Hospital of China Medical UniversityNo.36 Sanhao StreetHeping DistrictShenyang 110004China Department of Ophthalmology Shengjing Hospital of China Medical UniversityNo.36 Sanhao StreetHeping DistrictShenyang 110004China Key Laboratory for Anisotropy and Texture of Materials Education Ministry of ChinaSchool of Materials Science and EngineeringNortheastern UniversityNo.3-11 Wenhua RoadHeping DistrictShenyang 110819China

Background:Co-Cr-Mo alloy has been widely used in clinical implants because of its excellent mechanical and anti-corrosion properties,but there is an urgent need to address its disadvantages,such as implant-related infections and implant *** synthesized Co-Cr-Mo-Cu(Co-Cu)alloys with different Cu contents to modify implant performance to be suitable as a bonecompatible implant ***:Microstructure,phase content and mechanical properties of the Co-Cr-Mo alloy were *** and immunohistochemical analyses were performed after implantation in *** experimental alloy was implanted on the lateral side of the lower tibial condyle and the tibial ***:Phase content and mechanical properties revealed that the crystallographic structure and wear resistance were *** implantation results demonstrated that osteogenic capability was markedly enhanced,ascribed to the excellent antibacterial and osseointegration capacities of Cu phases,and with the release of Cu *** particular,Co-Cu alloy containing 2 wt%Cu exhibited the best osteogenic performance among all ***:The results indicated that osteogenic performance of the Co-Cr-Mo alloy could be enhanced by adding *** particular,the Co-2Cu alloy exhibited the best properties according to both immunohistochemical and histological *** study not only provides deep insight into the osteogenic effect of Cu but presents a new Co-Cu alloy for clinical implants.

关键词： Co-Cr-Mu-Cu alloy Cu ion Osteogenic capability implantable operation Clinical application

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