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Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1589-1597页

作者： Leonardo Mastropasqua Silvio Di Staso Rossella D’Aloisio Alessandra Mastropasqua Luca DiAntonio Alfonso Senatore Marco Ciancaglini Marta Di Nicola Giuseppe Di Martino DanieleTognetto Lisa Toto Department of Medicine and Science of Ageing OphthalmologyClinicUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Life Health and Environmental SciencesOphthalmology ClinicUniversity of L’AquilaL’Aquila67100Italy Department of Medicine Surgery and Health SciencesEyeClinicUniversity of TriesteTrieste34129Italy Department of Medical Oral and Biotechnological SciencesLaboratory of BiostatisticsUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Medicine and Science of Ageing School ofHygiene and Preventive MedicineUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy

AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological ***: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all ***: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye ***: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.

关键词： optical coherence tomography angiography diabetic macular edema intravitreal dexamethasone implant intravitreal ranibizumab injections

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Comparative Evaluation of the implant Made of Yttrium-partially Stabilized Zirconia and Pure Titanium on Stress Distribution by Anisotropic Finite Element Method

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 147-149页

作者：满毅宫苹 West China Stomatology College Sichuan University Chengdu 610041 China

The purpose of this research is to analyze and compare stress distribution patterns around dental implant made of pure titanium and yttrium-partial stabilized zirconia （YPSZ） in anisotropic versus isotropic finite element method under vertical and oblique loads. Although the properties of implant and crown were changed, similar stress distribution and close stress level were observed in two different implant finite element models. The stress values were a little lower in the YPSZ model. In the bone, anisotropy increased the stress values by 30%- 70% in the isotropic cases. The YPSZ implant could be more valuable choice for implant because of esthetic requirement. Anisotropy had subtle, yet significant effects on the stress level.

关键词： finite element anisotropic elasticity zirconia implant

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Cochlear implant challenges encountered in tuberculous otitis media

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 416-419页

作者： Cheng-Fang Chen Zhao-Hui Liu Jing Xie Xiao-Bo Ma Yi Li Shu-Sheng Gong Department of Otolaryngology Head and Neck SurgeryBeijing Tongren HospitalCapital Medical Unirersity Department of Radiology Beijing Tongren HospitalCapital Medical University Department of Otolaryngology Head and Neck SurgeryBeijing Tongren HospitalCapital Medical University

Tuberculous otitis media(TOM) is rare in ENT department,and is frequently misdiagnosed as otitis *** early systemic treatment is very important for *** reported a case report with TOM to highlight development of the disease and difficulties in clinical treatment in late stage of *** of ossified and eroded cochlea poses many unique challenges to both the surgeon and programming *** thorough preparation and complete knowledge about characters of specific issues,implantation would be performed successfully,and patients with ossified cochlear could benefit from cochlear implantation.

关键词： Tuberculous otitis media Cochlear implant Ossification Cochlear drill-out

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Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 866-869页

作者： Gabriella Cirigliano Marco R Pastore Alberto A Perrotta Chiara De Giacinto Daniele Tognetto Eye Clinic Department of Medical Surgical Sciences and HealthUniversity of Trieste

Dear Editor,Endothelial cell density decreases with age and in various ocular conditions,including corneal endotheliitis,uveitis,pseudoexfoliation syndrome,and birth injury(1)The reduction of endothelial cell density is exacerbated over time after intraocular surgery(1)Descemet stripping automated endothelial keratoplasty(DSAEK)is considered the primary procedure for patients with only endothelial dysfunction.

关键词： PBK Figure Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema IOL IOP

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Ceftriaxone-induced immune hemolytic anemia in a case with large vestibular aqueduct syndrome after cochlear implant

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Chinese Medical Journal 2019年第1期132卷 100-102页

作者： Yu Wang Tao Pan Fu-Rong Ma Ji-Jun Wang Ke Zhang Wei-Wei Pan Jing-Hui Zhang Zhan-Miao Yi Ying-Qiu Ying Department of Otolaryngology Peking University Third HospitalBeijing 100191China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Department of Pharmacy Peking University Third HospitalBeijing 100191China

To the Editor:Drug-induced immune hemolytic anemia (DIIHA)is a rare but severe ***,a third-generation cephalosporin with a wide antibacterial spectrum and effective antibacterial action,is one of the most common drugs causing DIIHA.^[1]Ceftriaxoneinduced immune hemolytic anemia (CIIHA)is a potentially fatal complication.^[2]Most of the patients were *** reported fatality rate of CIIHA was as high as 40%.

关键词： Ceftriaxone-induced immune hemolytic anemia large vestibular aqueduct syndrome cochlear implant

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Xen45 Gel Stent implant: patient reported outcomes

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1503-1506页

作者： Faaiq Hassan Luke Thomas Middleton Thomson Gurpal Toor Qusay Alfahad Department of Ophthalmology South Warwickshire NHS foundation trust

Our aim was to report quality of life(QOL) outcomes following Xen45 Gel Stent implantation surgery in patients suffering with primary open angle glaucoma(POAG). A retrospective analysis was performed on all patients who had Xen45 implantation surgery during a 2-year period(Jun, 2016-Apr, 2018). Of 52 consecutive patients were included with a total of 58 eyes being operated on. QOL was compared both pre-operatively and 6 weeks postoperatively using the GQL-15 questionnaire. There was an overall improvement in GQL-15 summary scores for our patient group. All item scores showed either no change or some degree of improvement. The Xen45 Gel Stent implant is a promising new intervention which has shown improved QOL scores in our patient group. Further, higher power studies are now needed to compare the Xen45 to trabeculectomy(TE), which is currently the gold standard.

关键词： glaucoma minimally invasive glaucoma surgery Xen45 Gel Stent implant

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Suprathreshold compound action potential amplitude as a measure of auditory function in cochlear implant users

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Journal of Otology 2017年第1期12卷 18-28页

作者： Rachel A.Scheperle Department of Communication Sciences and Disorders University of Iowa Department of Communication Sciences and Disorders Montclair State University

Electrically evoked compound action potential(e CAP) amplitudes elicited at suprathreshold levels were assessed as a measure of the effectiveness of cochlear implant(CI) stimulation. Twenty-one individuals participated; one was excluded due to facial stimulation during e CAP testing. For each participant, e CAPs were elicited with stimulation from seven electrodes near the upper limit of the individual's electrical dynamic range. A reduced-channel CI program was created using those same seven electrodes, and participants performed a vowel discrimination task. Consistent with previous reports, e CAP amplitudes varied across tested electrodes; the profiles were unique to each individual. In 6subjects(30%), e CAP amplitude variability was partially explained by the impedance of the recording electrode. The remaining amplitude variability within subjects, and the variability observed across subjects could not be explained by recording electrode impedance. This implies that other underlying factors, such as variations in neural status across the array, are responsible. Across-site mean e CAP amplitude was significantly correlated with vowel discrimination scores(r^2= 0.56). A single e CAP amplitude measured from the middle of the array was also significantly correlated with vowel discrimination, but the correlation was weaker(r^2= 0.37), though not statistically different from the acrosssite mean. Normalizing each e CAP amplitude by its associated recording electrode impedance did not improve the correlation with vowel discrimination(r^2= 0.52). Further work is needed to assess whether combining e CAP amplitude with other measures of the electrode-neural interface and/or with more central measures of auditory function provides a more complete picture of auditory function in CI recipients.

关键词： Cochlear implant Compound action potential Suprathreshold amplitude

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Scleral tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case report

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1986-1987页

作者： Ying Huang Bing Lin Li-Na Ge Xiao-Ling Liu Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Citation:Huang Y,Lin B,Ge LN,Liu *** tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case *** J Ophthalmol 2021;14(12):1986-1987 Dear Editor,We present a case of scleral tunnel leakage induced by injection of dexamethasone intravitreal implant(Ozurdex®)for recurrent Vogt-Koyanagi-Harada(VKH)*** informed consent was obtained by the patient to allow publication of the present case and any related image and this case study is in accordance with the tenets of the Declaration of Helsinki.

关键词： injection Vogt implant

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Challenging aspects of contemporary cochlear implant electrode array design

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 192-199页

作者： Pavel Mistrík Claude Jolly Daniel Sieber Ingeborg Hochmair MED-EL Company Austria

Objective:A design comparison of current perimodiolar and lateral wall electrode arrays of the cochlear implant (CI) is *** focus is on functional features such as acoustic frequency coverage and tonotopic mapping,battery consumption and dynamic range.A traumacity of their insertion is also ***:Review of up-to-date ***:Perimodiolar electrode arrays are positioned in the basal turn of the cochlea near the *** are designed to initiate the action potential in the proximity to the neural soma located in spiral *** the other hand,lateral wall electrode arrays can be inserted deeper inside the cochlea,as they are located along the lateral wall and such insertion trajectory is less *** class of arrays targets primarily surviving neural peripheral *** to their larger insertion depth,lateral wall arrays can deliver lower acoustic frequencies in manner better corresponding to cochlear *** fact,spiral ganglion sections containing auditory nerve fibres tuned to low acoustic frequencies are located deeper than 1 and half turn inside the *** this reason,a significant frequency mismatch might be occurring for apical electrodes in perimodiolar arrays,detrimental to speech *** languages such as Mandarin might be therefore better treated with lateral wall *** the other hand,closer proximity to target tissue results in lower psychophysical threshold levels for perimodiolar ***,the maximal comfort level is also lower,paradoxically resulting in narrower dynamic range than that of lateral wall *** consumption is comparable for both types of ***:Lateral wall arrays are Less likely to cause trauma to cochlear *** the current trend in cochlear implantation is the maximal protection of residual acoustic hearing,the Lateral wall arrays seem more suitable for hearing preservation Cl *** development could focus on combini

关键词： Cochlear implant

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Progress in implant-Based Breast Reconstruction:What Do We Know?

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Chinese Journal Of Plastic and Reconstructive Surgery 2021年第2期3卷 103-108页

作者： Xueqing HU Cheng HUANG Department of Plastic and Reconstructive Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou Zhejiang 310009China

Breast cancer is the most common malignancy and the most frequently diagnosed cancer in women *** China,the incidence rate of breast cancer among women has been showing an upward trend and is higher in urban *** of clinical research have made considerable progress,which is attributable to improved mastectomy and maintenance of a well-perfused skin flap after *** in-depth insight into the nature of breast cancer will contribute to reduced overall mortality and prolonged *** China,there is an increasing awareness of the importance of breast reconstruction in improving quality of life(QoL)and life *** has been progress in breast reconstruction surgical procedures due to demand from *** should be aware that breast reconstruction is not only a medical problem but also a surgical *** the following sections,we present the epitome of advances in implant-based breast reconstruction.

关键词： Breast reconstruction implant Acellular dermal matrix Expander

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