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Hepatitis E in hemodialysis and kidney transplant patients in south-east Italy

World Journal of Gastroenterology 2015年第11期21卷 3266-3273页

作者： Gaetano Scotto Filippo Aucella Giuseppe Grandaliano Domenico Martinelli Mario Querques Antonio Gesuete Barbara Infante Paolo Delli Carri Salvatore Massa Giovanna Salatino Fabio Bulla Vincenzina Fazio Microbiology and Clinical Microbiology Master’s Degree in DentistryUniversity of Foggia Nephrology and Dialysis Unit IRCCS "Casa Sollievo della Sofferenza" San Giovanni Rotondo (FG) Nephrology and Dialysis Unit University of Foggia Institute of Hygiene University of Foggia Division of Nephrology Hospital of Foggia Department of Agricultural Food and Environmental SciencesUniversity of Foggia Clinic of Infectious Diseases University of Foggia Clinical Chemistry Laboratory Unit of VirologyHospital of Foggia

AIM:To investigate the serovirological prevalence and clinical features of hepatitis E virus(HEV) infection in end-stage renal failure patients and in the healthy ***:HEV infection is a viral disease that can cause sporadic and epidemic *** studies unexpectedly showed a high prevalence of HEV antibodies in immunosuppressed subjects,including hemodialysis(HD)patients and patients who had undergone kidney transplant.A cohort/case-control study was carried out from January 2012 to August 2013 in two hospitals in southern Italy(Foggia and *** Rotondo,Apulia).The seroprevalence of HEV was determined in 801 subjects;231 HD patients,120 renal transplant recipients,and450 health *** HD patients and the recipients of renal transplants were attending the Departments of Nephrology and Dialysis at two hospitals located in Southern Italy,and were included progressively in this *** samples were tested for HEV antibodies(Ig G/Ig M);in the case of positivity they were confirmed by a Western blot assay and were also tested for HEV-RNA,and the HEV genotypes were ***:A total of 30/801(3.7%)patients were positive for anti-HEV Ig(Ig G and/or Ig M)and by Western *** healthy population presented with a prevalence of 2.7%,HD patients had a prevalence of 6.0%,and transplant recipients had a prevalence of 3.3%.The overall combined HEV-positive prevalence in the two groups with chronic renal failure was 5.1%.The rates of exposure to HEV(positivity of HEV-Ig G/M in the early samples)were lower in the healthy controls,but the difference among the three groups was not statistically significant(P>0.05).Positivity for anti-HEV/Ig M was detected in 4/30(13.33%)anti-HEV Ig positive individuals,in 2/14 HD patients,in1/4 transplant individuals,and in 1/12 of the healthy *** relative risk of being HEV-Ig M-positive was significantly higher among transplant recipients compared to the other two groups(OR=65.4,95%CI:7.

关键词： Hepatitis E virus infection Prevalence immunosuppr

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