检索结果-南通市图书馆

Clinicopathologic diagnosis of dVIN related vulvar squamous cell carcinoma:An extended appraisal from a tertiary women's hospital

引用

Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 30-37页

作者： Tiannan Wang Vandana Baloda Lakshmi Harinath Terrell Jones Huina Zhang Rohit Bhargava Chengquan Zhao Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical CenterPittsburghPA15213USA Department of Pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033USA Department of Pathology University of Rochester Medical CenterRochesterNY14642USA

Background:Differentiated vulvar intraepithelial neoplasia(dVIN)is a non-human papilloma virus(HPV)-related high-grade precursor lesion to vulvar squamous cell carcinoma(vSCCa).Although TP53 gene mutations have been identified in 80%of dVIN,its role in dVIN pathogenesis as well as malignant transformation is still being poorly *** reproducible diagnostic criteria and ambiguous p53 immunostaining patterns,along with morphologic discordance still pose a diagnostic ***:A series of 60 cases of dVIN-related vSCCa along with adjacent dVIN were *** features as well as immunohistochemical results were recorded on the resection-confirmed dVIN-related ***:The average age of the patients was 71 ***-five cases(58.4%)of dVIN-related vSCCa were moderately differentiated,fourteen cases(23.3%)were poorly differentiated,and the remaining eleven cases(18.3%)were ***-nine cases(48.3%)were found to have lichen sclerosus adjacent to *** terms of p53 and p16 expression in dVIN-related vSCCa and the adjacent dVIN,fifty-five(91.7%)dVIN showed mutant p53 immunostaining pattern with strong positive expression in 80%cases(basal/para-basal expression)and null pattern expression in 11.7%***(8.3%)dVIN showed p53 wild-type staining *** wild-type pattern were seen in 5%of vSCCa and p53 null pattern were seen in 13.3%*** cases demonstrated atypical staining patterns:two cases showed p53 null expression in dVIN but p53 overexpression in invasive carcinoma;three cases exhibited p53 null expression in invasive carcinoma,with the adjacent dVIN showing basal and para-basal mutant(2 cases)and wild-type(1 case)p53 expression patterns.A single case demonstrated p53 wild-type pattern in dVIN and overexpression in invasive *** addition,65%dVIN were p16 negative and 31.7%dVIN had patchy p16 ***:Clinical and prognostic value of the ambiguous/inconsistent patterns are u

关键词： Differentiated vulvar intraepithelial neoplasia Vulvar squamous cell carcinoma Clinicopathologic features immunostaining patterns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：