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Food Science and Human Wellness 2023年第2期12卷 467-476页

作者： Yanfang Qian Chenying Shi Chen Cheng Dengwei Liao Junping Liu Guitang Chen College of Engineering/National R&D Center for Chinese Herbal Medicine Processing China Pharmaceutical UniversityNanjing 211198China

In previous study,we got a purified ginger polysaccharide UGP1 and verified its significant antitumor activities on colon cancer HCT116 *** this article,we aimed to illustrate the underlying mechanism of UGP1 exerted antitumor activities on colon cancer by using in vitro cell models and in vivo animal *** results demonstrated that UGP1 could induce S-phase cell cycle arrest,up-regulate the expression of Bax and p53,down-regulate the expression of Bcl-2,and activate the downstream protein caspase-9 and caspase-3,which was related to intrinsic apoptosis pathway on HCT116 ***,UGP1 significantly stimulated RAW264.7 cell proliferation and secretion ***,UGP1 inhibited tumor proliferation on tumor-bearing mice,increased the expression of p53 and the ratio of Bax/Bcl-2,enhanced the secretion of pro-inflammatory cytokines TNF-α,IL-2,IL-6 and decreased the secretion of pro-tumor cytokines TGF-βand b FGF in *** conclusion,it indicated that the UGP 1 could sup press human colon cancer growth by inducing apoptosis via the regulation of p53,caspase-3,and Bax/Bcl-2 ratio-dependent pathway and regulating immune system *** s investigation provided basic theoretical mechanism of ginger polysaccharideexerted antitumor activities,and contributed to develop a possible functional food or adjuvant agent for prevention or treatment of colon cancer.

关键词： Ginger polysaccharide Apoptosis p53 Bcl-2 immunomodulation

Rational design of hydrogels for immunomodulation

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Regenerative Biomaterials 2022年第1期9卷 979-1000页

作者： Wenhuan Bu Yuanhao Wu Amir M.Ghaemmaghami Hongchen Sun Alvaro Mata Liaoning Provincial Key Laboratory of Oral Diseases School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Dental Materials School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Center Laboratory School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China School of Pharmacy University of NottinghamUniversity ParkNottingham NG72RDUK Biodiscovery Institute University of NottinghamUniversity ParkNottingham NG72RDUK Division of Immunology School of Life SciencesUniversity of NottinghamUniversity ParkNottingham NG72RDUK Terasaki Institute for Biomedical Innovation 1018 Westwood BlvdLos AngelesCA 90024USA Department of Chemical and Environmental Engineering University of NottinghamUniversity ParkNottingham NG72RDUK

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development,repair and *** immunomodulatory biologics exhibit limitations including degradation by enzymes,short half-life and lack of targeting *** or binding these biologics within biomaterials is an effective way to address these *** are promising immunomodulatory materials because of their prominent biocompatibility,tuneability and ***,to take advantage of these opportunities and optimize material performance,it is important to more specifically elucidate,and leverage on,how hydrogels affect and control the immune ***,we summarize how key physical and chemical properties of hydrogels affect the immune *** first provide an overview of underlying steps of the host immune response upon exposure to ***,we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through(i)physical properties including dimensionality,stiffness,porosity and topography;(ii)chemical properties including wettability,electric property and molecular presentation;and(iii)the delivery of bioactive molecules via chemical or physical ***,this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response.

关键词： hydrogels immunomodulation physical properties chemical properties

Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis

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Bioactive Materials 2022年第5期7卷 77-89页

作者： Hebatullah Hussein Anil Kishen The Kishen Lab Dental Research InstituteUniversity of TorontoTorontoON M5G 1G6Canada Faculty of Dentistry University of TorontoTorontoON M5G 1G6Canada Faculty of Dentistry Ain Shams UniversityEndodontics DepartmentCairoEgypt School of Graduate Studies University of TorontoTorontoON M5G 1G6Canada Department of Dentistry Mount Sinai Health SystemMount Sinai HospitalTorontoON M5G 1X5Canada

Macrophages(MQ)are major constituents of chronically inflamed periapical tissues in apical *** study aimed to investigate the immunomodulatory effect of engineered bioactive chitosan-based nanoparticles(CSnp)antibiofilm medication on MQ cocultured with periodontal ligament fibroblasts(PdLF).Cells viability,spreading,PdLF migration,and intracellular CSnp uptake were *** Mass Tag-based proteomics was applied to analyze MQ global protein expression profiles after interaction with Enterococcus faecalis biofilm,CSnp-treated biofilm,and *** inflammatory mediators were *** bioinformatics analyses,candidate proteins were validated via targeted *** maintained cells viability,increased MQ spreading,and PdLF migration(p1.5-folds,p1.5-folds,p<0.05)was ***-treated biofilm reduced pro-inflammatory IL-1β and nitric oxide but enhanced anti-inflammatory IL-10 and TGF-β1(p<0.05).Internalized engineered bioactive CSnp reprogrammed MQ proteomic and cytokine profiles to modulate biofilm-mediated inflammation,and prompted PdLF migration,emphasizing its potential to regulate healing process in the treatment of apical periodontitis.

关键词： Chitosan-based nanoparticles Macrophages immunomodulation Tandem mass tags Mass spectrometry Endodontics

Applications of scaffolds:Tools for enhancing the immunomodulation of mesenchymal stromal cells

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BIOCELL 2022年第6期46卷 1439-1443页

作者： OK-HYEON KIM EUN RAN KIM JUN HYUNG PARK HYUN JUNG LEE Department of Anatomy and Cell Biology College of MedicineChung-Ang UniversitySeoul06974South Korea Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974South Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteCollege of MedicineYonsei UniversitySeoul03722South Korea

Exogenously delivered mesenchymal stromal cells(MSCs)are therapeutically beneficial owing to their paracrine effect;they secrete various cytokines,nucleic acids,and *** bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions(both structurally and functionally).Various scaffolds mimic the natural extracellular matrix(ECM)using both natural and synthetic polymers,providing favorable environments for MSC proliferation and *** on material properties,either topographically or elastically structured scaffolds can be ***-dimensional scaffolds have tunable substrate rigidities and structures,aiding MSC *** ECM-derived hydrogels are similar to the natural ECM,thus improving the paracrine effects of ***,we discuss recent research on the application of scaffolds to maximize the immunomodulatory function of MSCs.

关键词： Extracellular matrix(ECM) immunomodulation Mesenchymal stromal cells(MSCs) Scaffolds Stem cell niche

Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages

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Regenerative Biomaterials 2022年第1期9卷 888-899页

作者： Xinhui Zheng Lan Chen Ji Tan Jianhua Miao Xuanyong Liu Tieyi Yang Zhihong Ding Department of Orthopedics Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Orthopedics Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China

The immune response induced by surface topography crucially determines the implant ***,how the immune response is mediated by the size of surface topography remains ***,various biocompatible Mg-Al layered double hydroxides sheet-array films with different sizes(nano,micro and nano/micro mixture)were constructed on the biomedical titanium,and their osteo-immunomodulation effects on the macrophages were *** nano-sheet array structures significantly promoted the polarization of M2 macrophages by activating the PI3K-AKT-mTOR signaling pathway with high gene expressions of integrin b2 and *** the micro-sheet array structures enhanced osteogenic differentiation of mouse bone marrow mesenchymal stem cells(mBMSCs)via ROCK-YAP/TAZ-mediated ***,the nano-sheet array structures promoted the osteogenic differentiation of mBMSCs with a high proportion of M2 macrophages through a shared *** study gave further information concerning integrin-induced focal adhesions in cells of different sheet array structures and their role in macrophage polarization and osteogenic differentiation of mBMSCs,which might help to design biomaterial surfaces with optimal geometry for a desired immunemodulation.

关键词： micro-nano topography immunomodulation macrophages osteogenesis

In vitro immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages

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Regenerative Biomaterials 2020年第4期7卷 391-401页

作者： Lei Sun Xiaoyu Li Menghan Xu Fenghe Yang Wei Wang Xufeng Niu Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityNo.37 XueYuan RoadHaidian DistrictBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityNo.37 XueYuan RoadHaidian DistrictBeijing 100083China Department of Immunology School of Basic Medical SciencesNHC Key Laboratory of Medical ImmunologyPeking UniversityNo.38 XueYuan RoadHaidian DistrictBeijing 100191China

Biodegradable magnesium(Mg)has shown great potential advantages over current bone fixation devices and vascular scaffold technologies;however,there are few reports on the immunomodulation of corrosive Mg products,the micron-sized Mg particles(MgMPs).Human monocytic leukemia cell line THP-1 was set as the in vitro cell model to estimate the immunomodulation of MgMPs on cell proliferation,apoptosis,polarization and inflammatory *** results indicated highconcentration of Mg^2+ demoted the proliferation of the THP-1 cells and,especially,THP-1-derived macrophages,which was a potential factor that could affect cell function,but meanwhile,cell apoptosis was almost not affected by Mg^2+.In particular,the inflammation regulatory effects of MgMPs were *** exposed to Mg^2+ exhibited down-regulated expressions of M1 subtype markers and secretions of pro-inflammatory cytokines,up-regulated expression of M2 subtype marker and secretion of anti-inflammatory *** results indicated Mg^2+ could convert macrophages from M0 to M2 phenotype,and the bioeffects of MgMPs on human inflammatory cells were most likely due to the Mg^2+-induced NF-jB activation ***,our results proved Mg^2+ could be used as a new anti-inflammatory agent to suppress inflammation in clinical applications,which may provide new ideas for studying the immunomodulation of Mg-based implants on human immune system.

关键词： immunomodulation magnesium THP-1 macrophage polarization

Effects of nutrients on immunomodulation in patients with severe COVID-19:Current knowledge

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World Journal of Critical Care Medicine 2022年第4期11卷 201-218页

作者： Bruna Teixeira da Costa Glauber Rocha Lima Araújo Ronaldo Teixeira da Silva Júnior Luana Kauany de SáSantos Vinícius Lima de Souza Gonçalves Daniel Bastos Alves Lima Beatriz Rocha Cuzzuol Jonathan Santos Apolonio Lorena Sousa de Carvalho Hanna Santos Marques Camilo Santana Silva Isadora de Souza Barcelos Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Recent research has demonstrated that critically ill patients with coronavirus disease 2019(COVID-19)show significant immune system *** to that,some nutrients that influence immunomodulation have been suggested as a form of treatment against the *** review collected the information on the impact of vitamins on the prognosis of COVID-19,with the intention of facilitating treatment and prevention of the disease risk status in *** collected information was obtained using the PubMed electronic database by searching for articles that relate COVID-19 and the mechanisms/effects of the nutrients:Proteins,glucose,lipids,vitamin B12,vitamin D,calcium,iron,copper,zinc,and magnesium,including prospective,retrospective,and support *** findings reveal an optimal response related mainly to omega-3,eicosapentaenoic acid,docosahexaenoic acid,calcium,and iron that might represent benefits in the treatment of critically ill ***,nutrient supplementation should be done with caution due to the limited availability of randomized controlled studies.

关键词： COVID-19 immunomodulation Patient care Vitamins Nutrients Micronutrients

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World Journal of Emergency Medicine 2018年第1期9卷 56-63页

作者： Yan Ma Xiang-you Yu Yi Wang Department of Intensive Care Unit the First Affiliated Hospital Xinjiang Medical University

BACKGROUND: Dexmedetomidine has already been used in septic patients as a new sedative agent, few studies have examined its effects on immunomodulation. Therefore, the authors have designed a controlled experimental study to characterize the immunomodulation effects of dexmedetomidine in the cecal ligation and puncture(CLP) model in rats. METHODS: After CLP, 48 Wistar rats were randomly allocated into four groups:(1) CLP group;(2) small-dose treatment group(2.5 g·kg^(-1)·h^(-1));(3) medium-dose treatment group(5.0 g·kg^(-1)·h^(-1)); and(4) large-dose treatment group(10.0 g·kg^(-1)·h^(-1)). HLA-DR and plasma cytokine(IL-4, IL-6, IL-10 and TNF-α) levels were measured, and the mean arterial blood pressure(MAP), heart rate(HR), arterial blood gases, lactate concentrations and mortality were also documented. RESULTS: The HLA-DR level, inflammatory mediator levels, MAP and HR had no obvious changes among Dexmedetomidine treatment groups(DEX groups). Compared with the CLP group, the DEX groups exhibited decreased HLA-DR levels(P_(group)=0.0202) and increased IL-6 production, which was increased at 3 h(P= 0.0113) and was then attenuated at 5 h; additionally, the DEX groups exhibited decreased HR(Pimmunomodulation that was initiated within 5 h, causing a decreased HR while maintaining MAP, remarkably improving metabolic acidosis and improving mortality dosedependently.

关键词： Dexmedetomidine immunomodulation Septic shock

DNA methylation and demethylation link the properties of mesenchymal stem cells: Regeneration and immunomodulation

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World Journal of Stem Cells 2020年第5期12卷 351-358页

作者： Tian-Yi Xin Ting-Ting Yu Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

Mesenchymal stem cells(MSCs)are a heterogeneous population that can be isolated from various tissues,including bone marrow,adipose tissue,umbilical cord blood,and craniofacial *** have attracted increasingly more attention over the years due to their regenerative capacity and function in *** foundation of tissue regeneration is the potential of cells to differentiate into multiple cell lineages and give rise to multiple tissue *** addition,the immunoregulatory function of MSCs has provided insights into therapeutic treatments for immune-mediated *** methylation and demethylation are important epigenetic mechanisms that have been shown to modulate embryonic stem cell maintenance,proliferation,differentiation and apoptosis by activating or suppressing a number of *** most studies,DNA hypermethylation is associated with gene suppression,while hypomethylation or demethylation is associated with gene *** dynamic balance of DNA methylation and demethylation is required for normal mammalian development and inhibits the onset of abnormal ***,the exact role of DNA methylation and demethylation in MSC-based tissue regeneration and immunomodulation requires further *** this review,we discuss how DNA methylation and demethylation function in multi-lineage cell differentiation and immunomodulation of MSCs based on previously published ***,we discuss the implications of the role of DNA methylation and demethylation in MSCs for the treatment of metabolic or immune-related diseases.

关键词： Mesenchymal stem cells DNA methylation and demethylation Multi-lineage differentiation Regeneration immunomodulation Immune disease

MELATONIN AND immunomodulation IN AGED AND IMMUNODEFICIENT MICE

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Journal of Pharmaceutical Analysis 2003年第2期15卷 205-208页

作者：周爱民袁育康范桂香 Dermatology and Vernerology Second Hospital of Xi'an Jiaotong University

Objective To investigate melatonin-related mechanisms of action on immunoregulation in aged and immunodeficient mice. Methods T lymPhocytes subunit CD4 + ,CD8 + and CD4 + /CD8 + ratio were measured by Flow Cytometer in normal, aged and Cyclophosphamide injected mice which treated with melatonin, and compared with the results of T lymphocytes subunit in the group without melatonin as control group. Results The percentage of CD4 + , CD8 + T cells in the normal mice which treated with melatonin was significantly higher than that in control group ( P <0.01), CD4 + /CD8 + ratio was higher but had no significant difference. In the cyclophosphamide injected group which melatonin treated, the percentage of CD4 + T cells and CD4 + /CD8 + ratio were higher than those in control, The difference was significant ( P <0.01), while CD8 + was lower ( P <0.01). In aged melatonin treated mice group, the percentage of CD4 + , CD8 + T cells and CD4 + /CD8 + ratio were significantly higher than those in control ( P <0.01). Conclusion Melatonin could adjust the quantity and the ratio of CD4 + , CD8 + T cells in aged and immunodeficient mice. it implied that melatonin could mediate helper and suppression T lymphocytes to reinforce their immunodefence.

关键词： melatonin CD4 + T lymphocytes CD8 + T lymphocytes immunomodulation