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The Study　on　immunological　response　of　Long－term　Release　System　hCG　Microsphere　in　C_(57）　Black　Mouse

Journal of Reproduction and Contraception 1996年第2期7卷 81-88页

作者：杜晓岩王健徐万祥朱康杰蒋宏亮刘世范 ShanghaiInstituteofPlannedParenthoodResearch Shanghai200032China DepartmentofPolymerScienceandEngineering ZhejiangUniversityHangzhou310027China

This paper describes the study of the immunological response of C57 Black mouse to hCG by multiple inoculations with hCG and single injection with a long-term release system of hCG/poly(lactide-co-glycolide) microsphere(hCG/PGLA).Three parameters including1)the dynamic variation of hCG antibody titres,2)the capacity of biological neutralization by hCG antibodies in vitro and in vivo,and3)assay of the binding affinity constants of hCG antibodies,are *** results showed that the single injection with hCG/PGLA was capable of producing high titres of anti-hCG *** analyses of three parameters of antisera from C57 Black mouse showed that the properties of the antisera elicited using a single injection with hCG/PGLA were generally similar to those of the antisera raised by the multiple inoculations with hCG,and concentration of the antibodies was directly proportional to hCG bioneutralization capacity. Meanwhile,all of these results suggest us that a further long-term release system of β-hCG/PGLA as a vaccine may substitute for conventional vaccine and it also provides a new convenient inoculative method for widespread clinical application and research of hCG vaccine and other vaccines.

关键词： immunological response hCG vaccine Long-term release microsphere

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Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome-Associated Toxoplasmic Encephalitis:A Prospective Observational Multicenter Study in China

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Infectious Diseases & Immunity 2024年第1期4卷 4-9页

作者： Yao Li Haidong Jiang Yanming Zeng Yanqiu Lu Siyuan Chen Yulin Zhang Zhongsheng Jiang Tongtong Yang Shuiqing Liu Yaokai Chen Department of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases Liuzhou People's HospitalLiuzhou 545006GuangxiChina Department of Infectious Disease The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Guiyang Public Health Clinical CenterGuiyang 550004GuizhouChina

Background:Toxoplasmic encephalitis(TE)is the most frequent cause of expansive brain lesions among patients with acquired immunodeficiency syndrome(AIDS).However,the optimal timing of antiretroviral therapy(ART)initiation in these patients remains *** study aims to investigate the differences in outcomes of ART initiation at different times,in order to help clarify the treatment timing of AIDS-associated ***:This multicenter prospective observational study included 87 patients recruited from 11 research centers in China(from March 2019 to December 2022).Of the patients,38 were assigned to the early ART group(initiating ART within 2 weeks after anti-Toxoplasma treatment initiation),and the remaining 49 patients received deferred ART(initiating ART at least 2 weeks after anti-Toxoplasma treatment initiation).The main outcomes includedmortality and emergence of immune reconstitution inflammatory syndrome(IRIS).Human immunodeficiency virus(HIV)-1 viral load and CD4^(+)T-cell counts at weeks 24 and 48 were ***:The number of deaths(1 vs.5,P=0.225)and incidence of IRIS(2.6%vs.0,P=0.437)were not significantly different between the early and deferred ART groups at week *** ART initiation did not contribute significantly to HIV-1 viral load control(immunological *** registration:This study was registered(registration number:ChiCTR1900021195)as one of 12 clinical trials under the title of a general project at the Chinese Clinical Trial Registry(***)on February 1,***

关键词： HIV Toxoplasma gondii Timing of antiretroviral therapy Virological outcome immunological response

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QUANTIFICATION OF CIRCULATING SCHISTOSOME ANTIGEN BY MONOCLONAL ANTIBODY-BASED ENZYME-LINKED IMMUNOSORBENT ASSAY

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中华医学杂志(英文版) 1991年第6期104卷 454-459页

作者：李正东钱宗立苏信生 Department of Parasitology Shanghai Second Medical University Shanghai 200025

A two-site enzyme-linked immunosorbent assay (2S-ELISA) was developed for the quantification of gut-associated schistosome circulating anodic proteoglycan (GASCAP) of Schistosoma japonicum using a monoclonal antibody (MeAb M120), purified by one-step hydroxylapatite (HAP) chromotography, as both solid phase and peroxidase-conjugated reagent. In this system, a high detectable level of serum GASCAP concentration (0.25 μg/L) could be achieved with the immanoaffinity purified GASCAP being used as the standard. The specificity of the assay was 97.2%, with minimized interference of rheumatoid factor. The intra-assay (4.01%) and interassay (6.09%) coefficients of variation and the mean analytical recovery (101.4%) for GASCAP demonstrated the precision and accuracy of the assay.

关键词： POLYSACCHARIDE ANTIGENS immunological response ANODIC ANTIGEN MANSONI PROTEOGLYCAN INFECTION MOUSE

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Cryptosporidiosis-an overview

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The Journal of Biomedical Research 2011年第1期25卷 1-16页

作者： Gordon J Leitch Department of Physiology Biochemistry and ImmunologyMorehouse School of Medicine

Apicomplexan protozoan parasites of the genus Cryptosporidium infect the gastrointestinal tract and lungs of a wide variety of animals, including humans. The majority of human infections are due to either Cryptosporidium hominis （C. hominis） and/or Cryptosporidium parvum （C. parvum）. The parasite has a complex life cycle that includes both asexual and sexual stages. While there are invasive free living stages, proliferation and differentiation take place within a unique parasitrophorous vacuole under the host cell brush border but outside the host cell cytoplasm. Infection is spread by environmentally resistant spores that primarily contaminate drinking water and occasionally food sources, which may cause significant outbreaks of diarrhea that generally lasts less than 2 w in immunocompetent individuals. In immunodeficient or immunosuppressed individuals, diarrhea may be copious and can result in significant morbidity and mortality, particularly in AIDS patients. Although diagnosis is relatively simple, effective drug treatment, particulary for infections in immunodeficient patients, has not been uniformly successful. This overview summarizes the species known to infect humans, aspects of the parasite life cycle, sources of infection, the pathophysiology of cryptosporidiosis, the immune response to infection, diagnosis, treatment and some aspects of cryptosporidiosis in China.

关键词： Cryptosporidium parvnm Cryptopridium hominis life cycle Cryptosporidium infections pathophysiology immunological response diagnosis treatment cryptosporidiosis China

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