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Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration

World Journal of Gastroenterology 2007年第14期13卷 2077-2082页

作者： Kazuya Akahoshi Yorinobu Sumida Noriaki Matsui Masafumi Oya Rie Akinaga Masaru Kubokawa Yasuaki Motomura Kuniomi Honda Masayuki Watanabe Takashi Nagaie Department of Gastroenterology Aso Iizuka Hospital Iizuka 820-8505Japan Department of Pathology Aso Iizuka Hospital Iizuka 820-8505Japan Department of Surgery Aso Iizuka Hospital Iizuka820-8505Japan

AIM： to evaluate the role of endoscopic ultrasonographyguided fine needle aspiration （EUS-FNA） in the preoperative diagnosis of gastrointestinal stromal tumor （GIST）.METHODS： From September 2002 to June 2006, Fiftythree consecutive EUS-FNAs of GI tract subepithelial hypoechoic tumors with continuity to proper muscle layer suspected as GIST by standard EUS were evaluated prospectively. The reference standards for the final diagnosis were surgery （n = 31）, or clinical follow-up （n = 22）. Additionally, immunophenotyping of specimens obtained by EUS-FNA and surgical resection specimens were compared.RESULTS： In 2 cases puncture was not performed because of anatomical problems. The collection rate of adequate specimens from the GI tract subepithelial hypoechoic tumor with continuity to proper muscle layer was 82% （42/51）. The diagnostic rate for the tumor less than 2 cm, 2 to 4 cm, and 4 cm or more were 71% （15/21）, 86% （18/21）, and 100% （9/9）,respectively. In 29 surgically resected cases, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of EUS-FNA using immunohistochemical analysis of GIST were 100%（24/24）, 80% （4/5）, 96% （24/25）, 100% （4/4）, and 97% （28/29）, respectively. No major complications were encountered.CONCLUSION： EUS-FNA with immunohistochemical analysis is a safe and accurate method in the pretherapeutic diagnosis of GIST. It should be taken into consideration in decision making, especially in early diagnosis following minimal invasive surgery for GIST.

关键词： Gastrointestinal stromal tumor Ultrasound-guided fine needle aspiration immunohistochemicalanalysis

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Expression of pyruvate dehydrogenase is an independent prognostic marker in gastric cancer

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World Journal of Gastroenterology 2015年第17期21卷 5336-5344页

作者： Xu-Ren Sun Zhe Sun Zhi Zhu Hai-Xia Guan Chen-Yan Li Jun-Yan Zhang Yi-Ning Zhang Huan Zhou Hui-Jing Zhang Hui-Mian Xu Ming-Jun Sun Department of Gastroenterology First Affiliated Hospital of China Medical University Department of Surgical Oncology First Affiliated Hospital of China Medical University Department of Endocrinology and Metabolism First Affiliated Hospital of China Medical University Department of Gastrointestinal Endoscopy First Affiliated Hospital of China Medical University

AIM:To investigate the expression and prognostic role of pyruvate dehydrogenase(PDH) in gastric cancer(GC).METHODS:This study included 265 patients(194 male,71 female,mean age 59 years(range,29-81 years) with GC who underwent curative surgery at the First Affiliated Hospital of China Medical University from January 2006 to May *** patients were followed up for more than 5 ***-derived paraffin embedded GC specimens were collected for tissue microarrays(TMAs).We examined PDH expression by immunohistochemistry in TMAs containing tumor tissue and matched nonneoplastic *** was evaluated independently by two *** survival(OS) rates were determined using the Kaplan-Meier *** with other clinicopathologic factors were evaluated by two-tailed χ2 tests or a two-tailed *** Cox proportional-hazard model was used in univariate analysis and multivariate analysis to identify factors significantly correlated with ***:Immunohistochemistry showed that 35.47% of total cancer tissue specimens had cytoplasmic PDH *** expression was much higher in normal mucosa specimens(75.09%;P = 0.001).PDH expression was correlated with Lauren grade(70.77% in intestinal type vs 40.0% in diffuse type;P = 0.001),lymph node metastasis(65.43% with no metastasis vs 51.09% with metastasis;P = 0.033),lymphatic invasion(61.62% with no invasion vs 38.81% with invasion;P = 0.002),histologic subtypes(70.77% in intestinal type vs 40.0% in diffuse type;P = 0.001) and tumor-node-metastasis(TNM) stage(39% in poorly differentiated vs 65.91% in well differentiated and 67.11% in moderately differentiated;P = 0.001) in *** expression in cancer tissue was significantly associated with higher OS(P < 0.001).The multivariate analysis adjusted for age,Lauren classification,TNM stage,lymph node metastasis,histological type,tumor size,depth of invasion and lymphatic invasion showed that the PDH expression in GC was an independe

关键词： Pyruvate dehydrogenase Gastric carcinoma Tissue microarray Prognosis immunohistochemicalanalysis

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