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Clinical characteristics and prognostic significance of immunoglobulin isotype switch in patients with multiple myeloma

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Cancer Pathogenesis and Therapy 2023年第2期1卷 149-153页

作者： Minqiu Lu Bin Chu Yutong Wang Lei Shi Shan Gao Lijuan Fang Qiuqing Xiang Xi Liu Yuehua Ding Yuan Chen Xin Zhao Mengzhen Wang Kai Sun Li Bao Department of Hematology Beijing Jishuitan HospitalThe Fourth Medical College of Peking UniversityBeijing 100096China

immunoglobulin(Ig)isotype switching in multiple myeloma(MM)is a rare form of clonal *** aim of this study was to investigate the clinical features and prognostic significance of Ig isotype switching by observing Ig transformation in patients with relapse.A retrospective analysis was performed on 506 patients with newly diagnosed MM who were treated at our hospital from February 2005 to February *** patients who experienced relapse were divided into the following four groups according to Ig phenotype:original paraprotein,complete isotype switching,light chain escape(LCE),and non-secretory clinical *** comparative purposes with the original paraprotein group,the last three groups were pooled as the transformation *** the 506 included patients,376(74.3%)*** them,13/376(3.5%)patients exhibited Ig isotype switching,including 3 with complete isotype switching,3 with LCE,and 7 with non-secretory clinical *** remained sensitive to therapy,exhibiting at least a partial *** patients survived for at least 20 months after *** median overall survival time of the LCE,clinical relapse,and complete isotype switching groups were 6,20,and 76 months,respectively,after *** clinical manifestations and Ig phenotypes of MM recurrence were different from those at the initial diagnosis in the 13 patients exhibiting Ig isotype *** differences vividly conveyed the heterogeneity of the clonal populations and provides direct clinical evidence for MM clonal evolution.

关键词： Multiple myeloma immunoglobulin isotype switch Clinical characteristics Prognosis Clonal evolution

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