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Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination

引用

Blood Science 2022年第3期4卷 170-173页

作者： Ganiyu Olatunbosun Arinola Elizabeth Disu Adedokun Babatunde Christopher Olopade Olufunmilayo Olopade Department of Immunology College of MedicineUniversity of IbadanNigeria Department of Pediatrics Lagos State University Teaching HospitalLagos StateNigeria Department of Medicine and the Center for Global Health University of ChicagoChicagoUSA Center for Clinical Cancer Genetics and the Center for Global Health University of ChicagoChicagoUSA

Background:Children with sickle cell disease(SCD)are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide *** call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal ***:The levels of humoral(innate and adaptive)immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with *** innate humoral immune factors[Complement factors(C1q and C4),transferrin,ferritin,and C-reactive protein(CRP)]and adaptive humoral immune factors[IgG,IgA,IgM,and IgE]were determined using *** essential trace elements such as iron(Fe),copper(Cu),and zinc(Zn)were measured also using an atomic absorption ***:The serum levels of certain innate humoral immune factors(ferritin,CRP,and C4),only one adaptive humoral immune factors(IgE),and essential trace elements(Fe,Zn,and Cu)were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination ***:Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive *** study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD.

关键词： immunoglobulin classes Innate Immunity Prevenar 13 pneumococcal vaccine Sickle cell disease

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