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Peripheral Mechanism of Cancer-Induced Bone Pain

Neuroscience Bulletin 2024年第6期40卷 815-830页

作者： Yachen Yang Wei Yang Ruofan Zhang Yanqing Wang Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesShanghai Medical CollegeInstitute of Acupuncture ResearchInstitutes of Integrative MedicineFudan UniversityShanghai200032China Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Shanghai Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai200032China Zhongshan-Fudan Joint Innovation Center Zhongshan528437China

Cancer-induced bone pain(CIBP)is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone *** constitutes a specific pain state with distinct characteristics;however,it shares similarities with inflammatory and neuropathic *** present,although various therapies have been developed for this condition,complete relief from CIBP in patients with cancer is yet to be ***,it is urgent to study the mechanism underlying CIBP to develop efficient analgesic ***,we focused on the peripheral mechanism associated with the initiation of CIBP,which involves tissue injury in the bone and changes in the tumor microenvironment(TME)and dorsal root *** nerve–cancer and cancer–immunocyte cross-talk in the TME creates circumstances that promote tumor growth and metastasis,ultimately leading to *** peripheral mechanism of CIBP and current treatments as well as potential therapeutic targets are discussed in this review.

关键词： Cancer-induced bone pain Peripheral mechanism Tumor microenvironment Sensory nerve immunocytes

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Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

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Neural Regeneration Research 2022年第12期17卷 2623-2631页

作者： Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma Research Center of Neurobiology The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Datong Fifth People’s HospitalDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of *** are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple *** studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin ***,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative *** increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell *** review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs *** review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based *** from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases.

关键词： Alzheimer’s disease cell-based therapy central nervous system cells fasudil immunocytes multiple sclerosis Parkinson’s disease pericytes Rho kinase inhibitor Rho-associated kinases

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Indoleamine 2,3-Dioxygenase in Endometriosis

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Reproductive and Developmental Medicine 2019年第2期3卷 110-116页

作者： Hui-Li Yang Ming-Qing Li Laboratory for Reproductive Immunology Insitute of Obstetrics and GynecologyHospital of Obstetrics and GynecologyFudan UniversityShanghai 200080China Laboratory for Reproductive Immunology Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesHospital of Obstetrics and GynecologyFudan UniversityShanghai 200011China Laboratory for Reproductive Immunology NHC Key Lab of Reproduction RegulationShanghai Institute of Planned Parenthood ResearchFudan UniversityShanghai 230032China

Endometriosis(EMS)is a chronic inflammatory and estrogen-dependent gynecological disease characterized by the presence of endometrial tissue outside the uterine *** it is a benign disease,EMS is tumor-like in several aspects,which include unrestrained growth,decreased apoptosis,and aggressive *** involves endocrine disorders and immunological *** 2,3-dioxygenase(IDO)is an intracellular enzyme that catalyzes the initial and rate-limiting step of the metabolism of *** is a potential candidate facilitating EMS *** IDO expression in both eutopic and ectopic endometria of women with EMS is biologically important in aspects,which include regulation of endometrial stromal cell function and modulation of adjacent local immunocytes to generate a supportive *** turn,the expression of IDO can be regulated by the complex endocrine-immune microenvironment networks in endometrial ***,we systematically review the roles of IDO in EMS to explore its pathological implications and treatment potential.

关键词： Endometrial Stromal Cells Endometriosis immunocytes Indoleamine 2,3-Dioxygenase

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锌缺乏对生长期大鼠免疫细胞凋亡的影响

锌缺乏对生长期大鼠免疫细胞凋亡的影响

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作者：单延春盛晓阳洪昭毅薛敏波上海第二医科大学附属新华医院儿保科

锌对免疫系统的发育和正常免疫功能的维持有着不可忽视的作用。锌缺乏导致机体免疫功能降低补充锌剂可增强机体抵抗力,但是锌通过何种机制影响机体免疫功能尚需进一步探讨。近年来一系列研究发现,在体外培养细胞中,高浓度的锌可抑制凋... 详细信息

锌对免疫系统的发育和正常免疫功能的维持有着不可忽视的作用。锌缺乏导致机体免疫功能降低补充锌剂可增强机体抵抗力,但是锌通过何种机制影响机体免疫功能尚需进一步探讨。近年来一系列研究发现,在体外培养细胞中,高浓度的锌可抑制凋亡而用络合剂去除锌则有促进细胞凋亡的作用。胸腺是中枢免疫器官,是T淋巴细胞分化成熟的场所:脾

关键词： Zinc immunocytes Apoptosis

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