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Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development

World Journal of Gastrointestinal Oncology 2023年第10期15卷 1717-1738页

作者： Tai-Liang Lu Cheng-Long Li Yong-Qiang Gong Fu-Tao Hou Chao-Wu Chen Department of General Surgery Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina

BACKGROUND mRNA vaccines have been investigated in multiple tumors,but limited studies have been conducted on their use for hepatocellular carcinoma(HCC).AIM To identify candidate mRNA vaccine antigens for HCC and suitable subpopu-lations for mRNA *** Gene expression profiles and clinical information of HCC datasets were obtained from International Cancer Genome Consortium and The Cancer Genome *** with somatic mutations and copy number variations were identified by cBioPortal *** differentially expressed genes with significant prognostic value were identified by Gene Expression Profiling Interactive Analysis 2 website *** Tumor immune Estimation Resource database was used to assess the correlation between candidate antigens and the abundance of antigen-presenting cells(APCs).Tumor-associated antigens were overexpressed in tumors and associated with prognosis,genomic alterations,and APC infiltration.A consensus cluster analysis was performed with the Consensus Cluster Plus package to identify the immune *** weighted gene coexpression network analysis(WGCNA)was used to determine the candidate biomarker molecules for appropriate populations for mRNA *** subtypes showed distinct cellular and clinical *** IS1 and IS3 immune subtypes were immunologically“cold”.The IS2 and IS4 immune subtypes were immunologically“hot”,and the immune checkpoint genes and immunogenic cell death genes were upregulated in these ***1-related modules were identified with the WGCNA ***,five hub genes(RBP4,KNG1,METTL7A,F12,and ABAT)were identified,and they might be potential biomarkers for mRNA *** AURKA,CCNB1,CDC25C,CDK1,TRIP13,PES1,MCM3,PPM1G,NEK2,KIF2C,PTTG1,KPNA2,and PRC1 have been identified as candidate HCC antigens for mRNA vaccine *** IS1 and IS3 immune subtypes are suitable populations for mRNA ***4,KNG1,METTL7A,F12,and ABAT are potential biomark

关键词： mRNA vaccine Hepatocellular carcinoma Immunotype Antigens immune subtypes

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