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World Journal of Emergency Medicine 2021年第3期12卷 185-191页

作者： Jun Yin Yao Chen Jun-ling Huang Lei Yan Zhong-shu Kuang Ming-ming Xue Si Sun Hao Xiang Yan-yan Hu Zhi-min Dong Chao-yang Tong Chun-xue Bai Zhen-ju Song Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Respiratory and Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of *** this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic ***:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December *** samples were collected at days 1 and *** cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune *** cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune *** of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 *** analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic *** with MARS had the highest mortality *** status of 46.1%patients changed from day 1 to day *** four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,***:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst *** preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation.

关键词： Infectious disease immune dysfunction immune status classifi cation Cytokine

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