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Characterization of heavy-chain antibody gene repertoires in Bactrian camels

Journal of Genetics and Genomics 2023年第1期50卷 38-45页

作者： Yuexing Liu Li Yi Yixue Li Zhen Wang Jirimutu CAS Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationCollege of Food Science and EngineeringInner Mongolia Agricultural UniversityHuhhotInner Mongolia 010018China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouZhejiang 310024China School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China Guangzhou Laboratory GuangzhouGuangdong 510005China Bio-Med Big Data Center Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Collaborative Innovation Center for Genetics and Development Fudan UniversityShanghai 200433China Inner Mongolia Institute of Camel Research West AlaxInner Mongolia 737399China

Camelids are the only mammals that can produce functional heavy-chain antibodies(HCAbs).Although HCAbs were discovered over 30 years ago,the antibody gene repertoire of Bactrian camels remains largely *** characterize the diversity of variable genes of HCAbs(VHHs),germline and rearranged VHH repertoires are *** analysis shows that all camelid VHH genes are derived from a common ancestor and the nucleotide diversity of VHHs is similar across all camelid *** species-specific hallmark sites are identified,the non-canonical cysteines specific to VHHs are distinct in Bactrian camels and dromedaries compared with *** low divergence at the germline repertoire between wild and domestic Bactrian camels,higher expression of VHHs is observed in some wild Bactrian camels than that of domestic *** study not only adds our understanding of VHH repertoire diversity across camelids,but also provides useful resources for HCAb engineering.

关键词： Bactrian camel Heavy-chain antibody Nanobody immune repertoire diversity Non-canonical cysteine

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