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Effects ofβ-alanine on intestinal development and immune performance of weaned piglets

Animal Nutrition 2023年第1期12卷 398-408页

作者： Linlin Chen Yan Zhong Xiangqin Ouyang Chunfeng Wang Lanmei Yin Jing Huang Yali Li Qiye Wang Junyan Xie Pengfei Huang Huansheng Yang Yulong Yin National Center of Technology Innovation for Synthetic Biology Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life SciencesHunan Normal UniversityChangshaHunan410081China Chinese Academy of Science Institute of Subtropical AgricultureResearch Center for Healthy Breeding of Livestock and PoultryChangshaHunan410125China

Beta-alanine is an important amino acid involved in several metabolic reactions in the body.The study aimed to investigate the effect ofβ-alanine supplementation on intestinal development and the immune performance of weaned piglets.Thirty-two 21-day-old healthy weaned piglets(half female and half male;Duroc×Landrace×Yorkshire)with an initial body weight of 8.11±0.21 kg were randomly divided into 4 groups with 8 replicates of 1 pig each.The control group was fed a basal diet and the three experimental treatment groups were fed diets supplemented with 300,600 and 1,200 mg/kgβ-alanine,respectively.The trial lasted 28 days and the diets fed were divided into 2 phases:the late lactation period(day 1 to 14)and the nursery period(day 15 to 28),during which the weaned piglets had free access to food and water.The regulatory effects ofβ-alanine were further investigated in vitro using organoids obtained from the jejunum of piglets.In vivo,the addition ofβ-alanine to the diet had no significant effect on the growth performance of weaned piglets(P>0.05),but significantly reduced serum levels of immunoglobulin G(IgG)(P<0.01),immunoglobulin M(IgM)(P=0.005),and complement 3(C3)(P=0.017).The serum interleukin-6(IL-6)levels(P<0.01)were significantly reduced in the 1,200 mg/kg treatment group.The addition ofβ-alanine increased ileal villus height,with the most significant effect at a concentration of 300 mg/kg(P=0.041).The addition of 600 mg/kgβ-alanine significantly up-regulated the expression of superoxide dismutase(SOD)activity(P=0.020)and the zonula occludens-1(ZO-1)gene(P=0.049)in the jejunum.Diets supplemented with 300 mg/kgβ-alanine significantly increased the number of Ki67 positive cells in the jejunal crypts(P<0.01).In vitro,β-alanine increased the organoid budding rates(P=0.001)and the budding height of the crypt significantly(P=0.004).In conclusion,β-alanine can improve intestinal morphology and barrier function,reduce inflammatory responses and alleviate the adverse effects of weaning stress on piglet intestinal hea

关键词： Weaned piglet Beta-alanine Intestinal development immune performance

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Applications and prospects of functional oligosaccharides in pig nutrition:A review

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Animal Nutrition 2023年第2期13卷 206-215页

作者： Nian Liu Haibo Shen Fan Zhang Xiang Liu Qinrui Xiao Qian Jiang Bie Tan Xiaokang Ma College of Animal Science and Technology Hunan Agricultural UniversityChangsha410128China

Oligosaccharides are low molecular weight carbohydrates between monosaccharides and poly-saccharides,which consist of 2 to 20 monosaccharides linked by glycosidic bonds.They have the effects of promoting growth,regulating immunity,improving the structure of intestinal flora,and are anti-inflammatory and antioxidant.With the comprehensive implementation of the antibiotic prohibition policy in China,oligosaccharides as new green feed additive have been paid more attention.Oligosac-charides can be divided into the following 2 categories according to their digestive characteristics:one is easy to be absorbed by the intestine,called common oligosaccharides,such as sucrose and maltose oligosaccharide;the other is difficult to be absorbed by the intestine and has special physiological functions,called functional oligosaccharides.The common functional oligosaccharides include mannan oligosaccharides(MOS),fructo-oligosaccharides(FOS),chitosan oligosaccharides(COS),xylo-oligosaccharides(XOS)and so on.In this paper,we review the types and sources of functional oligo-saccharides,their application in pig nutrition,and the factors limiting their efficacy in recent years.This review provides the theoretical basis for further research of functional oligosaccharides,and the future application of alternative antibiotics in pig industry.

关键词： Functional oligosaccharides Pig nutrition Growth performance Intestinal health Antioxidants immune performance

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