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3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells

Engineering 2022年第10期17卷 183-195页

作者： Cuidi Li Zhenjiang Ma Wentao Li Tianyang Jie Liping Zhong Hongfang Chen Wenhao Wang Jinwu Wang Wenguo Cui Yongxiang Zhao Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor TheranosticsGuangxi Medical UniversityNanning 530021China

The immune response after implantation is a primary determinant of the tissue-repair effects of threedimensional(3D)-printed ***,scaffolds that can subtly regulate immune responses may display extraordinary *** by the angiogenesis promotion effect of humoral immune response,we covalently combined mesoporous silica micro rod(MSR)/polyethyleneimine(PEI)/ovalbumin(OVA)self-assembled vaccines with 3D-printed calcium phosphate cement(CPC)scaffolds for local antigen-specific immune response *** the response activated,antigen-specific CD4+T helper2(Th2)cells can be recruited to promote early *** silicon(Si)ions from MSRs can accelerate osteogenesis,with an adequate blood supply being *** room temperature,scaffolds with uniformly interconnected macropores were printed using a self-setting CPC-based printing paste,which promoted the uniform dispersion and structural preservation of functional polysaccharides oxidized hyaluronic acid(OHA)*** release of OVA was achieved with MSR/PEI covalently attached to scaffolds rich in aldehyde groups as the vaccine *** vaccine-loaded scaffolds effectively recruited and activated dendritic cells(DCs)for antigen presentation and promoted the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in *** embedded subcutaneously in vivo,the vaccine-loaded scaffolds increased the proportion of Th2 cells in the spleen and locally recruited antigenspecific T cells to promote angiogenesis in and around the ***,the result in a rat skull defect-repair model indicated that the antigen-specific vaccine-loaded scaffolds promoted the regeneration of vascularized *** method may provide a novel concept for patient-specific implant design for angiogenesis promotion.

关键词： 3D printing immune microenvironment regulating Angiogenesis Bone regeneration

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