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enhancement of Humoral immune Response of Newcastle Disease Vaccine by ATRA

Animal Husbandry and Feed Science 2017年第4期9卷 226-228页

作者： Ren Chao Cao Wei Zhang Wenbo Jin Tianming Department of Animal Sciences and Veterinary Medicine Tianjin Agricultural University

[ Objective] The paper was to study the immune enhancement of ATRA on Newcastle Disease （ND） vaccine. [ Method ] The 1-day-old AA broilers were treated with ATRA at the doses of I and 5 ***/kg, respectively. At 7 and 28 days of age, broilers in drug control group, low dose group and high dose group were immunized with ND vaccine by intranasal and eye immunization approach. At 7, 14, 21, 28, 35, 42 and 49 clays of age, seven chickens were randomly se- lected from each group and weighed. The thymus, spleen, bursa of fabrieius and serum were collected for calculating immune organ index of thymus, spleen and bursa of fabricius. The ND specific antibody titers in serum were determined with HI test. [Result] ATRA promoted the growth of thymus, spleen and bursa of fabricius, and improved the immune organ index and ND specific antibody titers of chicks. [ Conclusion] ATRA enhanced the humoral immune response of chicks, and ATRT at the dose of 5 μmol/kg presented more prominent immune enhancement effect on ND vaccine.

关键词： ATRA ND vaccine Humoral immune immune enhancement immune organ index

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Medium-chain fatty acids and monoglycerides as feed additives for pig production:towards gut health improvement and feed pathogen mitigation

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Journal of Animal Science and Biotechnology 2020年第3期11卷 611-625页

作者： Joshua A.Jackman RDean Boyd Charles C.Elrod School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Hanor Company FranklinKY 42134USA North Carolina State University RaleighNC 27695USA Natural Biologics Inc. NewfieldNY 14867USA Department of Animal Science Cornell UniversityIthacaNY 14853USA.

Ongoing challenges in the swine industry,such as reduced access to antibiotics and virus outbreaks(e.g.,porcine epidemic diarrhea virus,African swine fever virus),have prompted calls for innovative feed additives to support pig ***-chain fatty acids(MCFAs)and monoglycerides have emerged as a potential option due to key molecular features and versatile functions,including inhibitory activity against viral and bacterial *** this review,we summarize recent studies examining the potential of MCFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed *** molecular properties and biological functions of MCFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig *** latest progress in testing MCFAs and monoglycerides as feed additives in pig diets is then presented,and their effects on a wide range of production issues,such as growth performance,pathogenic infections,and gut health,are *** utilization of MCFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described,along with advances in molecular encapsulation and delivery ***,we discuss how MCFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease *** forward,we envision that MCFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

关键词： Antibiotics Feed pathogen mitigation Growth promotion Gut health immune enhancement MCFA Medium-chain fatty acids Monoglycerides

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Implantable sandwich PHBHHx film for burst-free controlled delivery of thymopentin peptide

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Acta Pharmaceutica Sinica B 2018年第3期8卷 432-439页

作者： Ke Peng Chengyu Wu Guoxu Wei Jinghui Jiang Zhirong Zhang Xun Sun Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education West China School of Pharmacy Sichuan University

Sustained release and non-parental formulations of peptides and protein drugs are highly desirable because of enhanced therapeutic effects as well as improved patient compliance. This is especially true for small peptides such as thymopentin(TP5). To this end, implantable sandwich poly(hydroxybutyrate-co-hydroxyhexanoate)(PHBHHx) films were designed to prolong release time and to inhibit burst release phenomenon of TP5 by a simple volatilization method. In vitro release studies revealed that sandwich films had nearly no burst release. In vivo release time of sandwich films was prolonged to 42 days. Pharmacodynamic evaluation demonstrated that TP5 sandwich films significantly increased survival rates in a rat immunosuppressive model and normalized CD4^+/CD8^+ values. These results suggest that TP5 released from sandwich films can attenuate cyclophosphamide's immunosuppressive activity, and possibly achieve results comparable to daily TP5 injection therapy. Thus, sandwich PHBHHx films show excellent potential as a sustained, burst-free release system for small molecular weight, hydrophilic peptide drugs.

关键词： Thymopentin Sustained release Burst-free release immune enhancement PHBHHx

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Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization

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Chinese Chemical Letters 2022年第9期33卷 4331-4334页

作者： Xingyu Heng Ruyan Feng Lijuan Zhu Liyin Yu Gaojian Chen Hong Chen College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow UniversitySuzhou 215006China

Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and ***(LPS)can promote DCs maturation by binding receptor on DCs surface,but their clinical application is limited due to biological *** many LPS analogues have been developed,complex synthesis and purification hinder their practical ***,we propose a novel and simple strategy to synthesize LPS analogues with adjustable structural *** monomer units similar to the key functional groups of LPS,we synthesize LPS analogues with different group ratios by RAFT *** obtained analogues have little negative effect on cell *** with LPS,the analogues show greater promoting effect on DCs *** the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are *** strategy provides a new direction for synthesizing LPS analogues,and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.

关键词： LPS analogues Glycopolymer RAFT polymerization Dendritic cells(DCs) immune enhancement

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Nature and mechanism of immune boosting by Ayurvedic medicine: A systematic review of randomized controlled trials

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World Journal of Methodology 2022年第3期12卷 132-147页

作者： B N Vallish Dimple Dang Amit Dang Medical Writing and Biostatistics MarksMan Healthcare CommunicationsHyderabad 500091TelanganaIndia Co-founder MarksMan Healthcare CommunicationsHyderabad 500032TelanganaIndia Founder and CEO MarksMan Helathcare Communications Pvt.LtdHyderabad 500091TelanganaIndia

BACKGROUND Many Ayurvedic preparations are claimed to have immune-boosting properties,as suggested in various published randomized clinical trials(RCTs)AIM To compile evidence on the nature and mechanism of immune system enhancement by Ayurvedic preparations in healthy and sick *** After prospectively registering study protocol with PROSPERO,we searched PubMed,DOAJ,Google Scholar,three dedicated Ayurveda research portals,two specialty Ayurveda journals,and reference lists for relevant records published until February 6,2021 using appropriate search *** features and data pertaining to the nature and mechanism of immune system function were extracted from all eligible *** quality was assessed using the Cochrane RoB-2 *** Of 12554 articles screened,19 studies reporting 20 RCTs(17 parallel group design,three crossover design)with 1661 unique patients were included;11/19 studies had Indian first *** population was included in nine studies,of which one study included pregnant women and two included pediatric population;remaining studies included patients with different health conditions,including one study with coronavirus disease 2019 patients.A total of 21 Ayurvedic interventions were studied,out of which five were composite *** predominant route of administration was oral;dose and frequency of administration of the intervention varied across the *** results reported with five RCTs exploring five Ayurvedic interventions were incomplete,ambiguous,or *** the remaining 16 interventions,indirect evidence of immune enhancement was reported with four interventions,while lack of the same was reported with two *** of T helper cells and natural killer cells was reported with three and four interventions,respectively,while the pooled results did not clearly point toward enhancement of other components of the immune system,including cytotoxic T cells,B lymphocyte

关键词： immune enhancement Ayurveda immune system Healthy volunteers Composite preparations NK cells

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immune Effects of Porcine Interleukin-2,4 on Piglets Using as Immunopotentiator for PCV Inactivated Vaccine

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Animal Husbandry and Feed Science 2015年第2期7卷 89-92,100页

作者： Zhang Hongbing Jinhua Polytechnic

[ Objective] To investigate the combined immunization of porcine circovirus 2 （PCV2） inactivated vaccine with PoIL-2,4. [ Methods] A total of 60 crossbred piglets were randomly divided into three groups, including the test group （ inoculation of 0.5 dose PCV2 inactivated vaccine with 0. 1 mL PoIL-2,4 at 14 and 28 day-old）, the positive control group （inoculation of 0.5 dose PCV2 inactivated vaccine） and the blank control group. [ Results ] The immune organ index, the lymphocyte transformation rates under different ages and the number of leukocytes and lymphocytes in peripheral blood increased significantly in test group, compared with control group. Moreover, the antibody and neutralizing antibody were also significantly higher in test group than that in control group. The clinical symptoms and pathological changes were not found, and the PC72 was not detected in serum and tissue after challenge test in test group, which indicated that the combined immunization of PCV2 inactivated vaccine with PoIL-2,4 significantly improved the lymphocyte transformation rate, effectively prevented the replication of PCV2 in organism, and enhanced the growth performance of piglets.

关键词： IL-2, 4 PCV2 inactivated vaccine Piglets immune enhancement Cellular immune

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