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Heterogeneity of immune control in chronic hepatitis B virus infection:Clinical implications on immunity with interferon-αtreatment and retreatment

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World Journal of Gastroenterology 2022年第40期28卷 5784-5800页

作者： Guo-Qing Yin Ke-Ping Chen Xiao-Chun Gu Center of Hepatology Zhong-Da HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

Hepatitis B virus(HBV)infection is a global public health ***-α(IFN-α)treatment has been used to treat hepatitis B for over 20 years,but fewer than 5%of Asians receiving IFN-αtreatment achieve functional ***,IFN-αretreatment has been introduced to enhance antiviral *** recent years,immune-related studies have found that the complex interactions between immune cells and cytokines could modulate immune response networks,including both innate and adaptive immunity,triggering immune responses that control HBV ***,heterogeneity of the immune system to control HBV infection,particularly HBV-specific CD8^(+)T cell heterogeneity,has consequential effects on T cell-based immunotherapy for treating HBV ***,the host’s genetic variants,negative-feedback regulators and HBV components affecting the immune system's ability to control *** this study,we reviewed the literature on potential immune mechanisms affecting the immune control of HBV and the clinical effects of IFN-αtreatment and retreatment.

关键词： Hepatitis B virus Chronic Functional cure Heterogeneity Immunity immune control Interferon-α Retreatment

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Fuzzy immune PSD control and Simulation

Fuzzy Immune PSD Control and Simulation

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2009中国控制与决策会议

作者： Hongbin Li~1,Lu Chen~2 1.Key Lab of Advanced Manufacturing & Automation Technology of Ludong University,Yantai 264025,China 2.Management College of Ludong University,Yantai 264025,China

Aiming at enhancing the performance of fuzzy immune PID control algorithm,combines the fuzzy immune PID control with the adaptive PSD control law,advances a fuzzy immune PSD control algorithm,achieves the adaptive tuning of the proportional,differential and integral *** experiments shows that adopting the fuzzy immune PSD control can obtain good performance and reduces the workload of parameter tuning.

关键词： Fuzzy control immune control Adaptive PSD control

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Advances in the study of tegument protein VP26 in white spot syndrome virus

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Aquaculture and Fisheries 2021年第5期6卷 448-454页

作者： Shengyu Liao Chan Zhu Dingji Shi Peimin He Rui Jia College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai201306China Institute of Botany Chinese Academy of SciencesBeijing100093China

White spot syndrome virus(WSSV)has become one of the most widespread causes of mortality in commercial shrimp farming due to its broad host range,rapid spread and high *** tegument protein VP26,which is loosely connected to nucleocapsid and envelope,is one of the major proteins of WSSV and has an important role in the initial stages of viral *** research has emphasized the vp26 gene,the structure of the VP26 protein,and VP26 binding *** knowledge is required to develop VP26 immune adjuvant to control *** paper reviews the related research of VP26 to provide reference for the prevention and treatment of WSSV.

关键词： White spot syndrome virus(WSSV) VP26 immune control

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