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Soluble CD163 and CD163 Expression on Monocytes Associated with Chronic Hepatitis B Inflammation and HBsAg Loss

Journal of Clinical and Translational Hepatology 2022年第6期10卷 1059-1067页

作者： Peilin Xie Bilian Yao Dao Huang Yongyan Chen Qiming Gong Xinxin Zhang Department of Infectious Diseases Research Laboratory of Clinical VirologyRuijin HospitalShanghai Jiao Tong Univer-sity School of MedicineShanghaiChina Department of General Practice Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Background and Aims:Monocyte/macrophage-associat-ed CD163 is an indicator of the severity of liver inflam-mation and cirrhosis,but the difference of soluble CD163(sCD163)levels in chronic hepatitis B(CHB)patients and hepatitis B surface antigen(HBsAg)-loss patients is ***,we aimed to compare the sCD163 levels in CHB patients and HBsAg-loss patients with or without an-tiviral ***:sCD163 and CD163 expres-sion on monocytes were compared among four groups,healthy subjects,treatment-naïve CHB patients,sponta-neous HBsAg-loss patients,and treatment-related HBsAg-loss *** correlation between sCD163 levels and clinical parameters in CHB patients was analyzed.A group of 80 patients with hepatitis B virus(HBV)infection and liver biopsy were ***:sCD163 levels were higher in the CHB group than in the other three ***163 levels were higher in treatment-related HBsAg-loss patients than in spontaneous HBsAg-loss ***163 levels were negatively correlated with hepatitis B e-antigen(HBeAg)and HBsAg levels in HBeAg-positive ***-er biopsy results further demonstrated that sCD163 levels were elevated in CHB patients with substantial inflamma-tion(A≥2)or fibrosis(F≥2).The sCD163 model was more sensitive in predicting inflammation than other noninvasive *** levels were higher in patients with normal ala-nine aminotransferase levels and significant inflammation(A≥2)than in patients with no or mild ***-clusions:sCD163 and CD163 expression on monocytes were associated with CHB inflammation and HBsAg loss,and may be used as markers to predict HBV-specific im-mune activation.

关键词： CD163 Hepatitis B virus HBsAg loss Monocytes immune activa-tion

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