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Tail regeneration reduction in lizards after repetitive amputation or cauterization reflects an increase of immune cells in blastemas

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Zoological Research 2018年第6期39卷 413-423页

作者： Lorenzo Alibardi Comparative Histolab Padua Department of BiologyUniversity of Bologna

Lizards are key amniote models for studying organ regeneration. During tail regeneration in lizards, blastemas contain sparse granulocytes, macrophages, and lymphocytes among the prevalent mesenchymal cells. Using transmission electron microscopy to examine scarring blastemas after third and fourth sequential tail amputations, the number of granulocytes, macrophages, and lymphocytes increased at 3-4 weeks in comparison to the first regeneration. An increase in granulocytes and agranulocytes also occurred within a week after blastema cauterization during the process of scarring Blood at the third and fourth regeneration also showed a significant increase in white blood cells compared with that under normal conditions and at the first regeneration. The extracellular matrix of the scarring blastema, especially after cauterization, was denser than that in the normal blastema and numerous white blood cells and fibroblasts were surrounded by electron-pale, fine fibrinoid material mixed with variable collagen fibrils. In addition to previous studies, the present observations support the hypothesis that an increase in inflammation and immune reactions determine scarring rather than regeneration. These new findings verify that an immune reaction against mesenchymal and epidermal cells of the regenerative blastema is one of the main causes for the failure of organ regeneration in amniotes.

关键词： Lizard Tail Repetitive regeneration Blood immune cells Ultrastructure

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

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Cellular & Molecular Immunology 2022年第3期19卷 421-431页

作者： Kevin Man Axel Kallies Ajithkumar Vasanthakumar Peter Doherty Institute for Infection and Immunity MelbourneVICAustralia Department of Microbiology and Immunology University of MelbourneMelbourneVICAustralia Olivia Newton-John Cancer Research Institute MelbourneVICAustralia

Glucose is a vital source of energy for all *** balance between glucose uptake,metabolism and storage determines the energy status of an individual,and perturbations in this balance can lead to metabolic *** maintenance of organismal glucose metabolism is a complex process that involves multiple tissues,including adipose tissue,which is an endocrine and energy storage organ that is critical for the regulation of systemic *** tissue consists of an array of different cell types,including specialized adipocytes and stromal and endothelial *** addition,adipose tissue harbors a wide range of immune cells that play vital roles in adipose tissue homeostasis and *** cells contribute to the regulation of systemic metabolism by modulating the inflammatory tone of adipose tissue,which is directly linked to insulin sensitivity and ***,these cells affect the control of *** lean adipose tissue is rich in type 2 and anti-inflammatory cytokines such as IL-10,obesity tips the balance in favor of a proinflammatory milieu,leading to the development of insulin resistance and the dysregulation of systemic ***,anti-inflammatory immune cells,including regulatory T cells and innate lymphocytes,protect against insulin resistance and have the characteristics of tissue-resident cells,while proinflammatory immune cells are recruited from the circulation to obese adipose ***,we review the key findings that have shaped our understanding of how immune cells regulate adipose tissue homeostasis to control organismal metabolism.

关键词： adipose tissue immune cells metabolism

Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells,rather than tumor cells in the breast cancer microenvironment

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World Journal of Clinical Cases 2020年第23期8卷 5935-5943页

作者： Rui-Bin Wang Yu-Chen Li Quan Zhou Shu-Zhen Lv Ke-Yu Yuan Jiang-Ping Wu Yan-Jie Zhao Qing-KunSong Bin Zhu Department of Emergency Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Cancer Research Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Pathology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Breast Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Medical Oncology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Clinical Epidemiology and Evidence-based Medicine Beijing Shijitan HospitalBeijing 100038China Department of Surgical Oncology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND CD155 is an immune checkpoint protein in cancers and interacts with ligands to regulate the immune *** expression of CD155 is correlated with the prognosis and pathological features of breast *** To investigate the expression status of CD155 and the association with exhausted CD4+helper and CD8+cytotoxic tumor infiltrating lymphocytes(TILs)and PD-L1 in the breast cancer *** One hundred and twenty-six breast cancer patients with invasive ductal breast cancer were consecutively recruited into this *** was used to detect the expression CD155,PD-L1 and PD-1 on tumor-infiltrating immune cells and tumor cells in the *** The proportion of patients with CD155 expression was higher in triple negative breast cancer(72.7%)than in Luminal A patients(22.2%,Pimmune cells,0.8%and 0.02%immune cells expressed PD-L1 in patients with positive and negative CD155 expression,respectively(Pimmune breast cancer ***155 was associated with a high proportion of exhausted CD4+and unexhausted CD8+TILs and high PD-L1 expression in immune cells.

关键词： Breast cancer CD155 PD-1 PD-L1 Tumor-infiltrating lymphocytes immune cells

Liver infiltration of multiple immune cells during the process of acute liver injury and repair

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World Journal of Gastroenterology 2022年第46期28卷 6537-6550页

作者： Yuan Xie Ke-Bo Zhong Yang Hu Yong-Lun Xi Shi-Xing Guan Meng Xu Yuan Lin Feng-Yong Liu Wei-Jie Zhou Yi Gao General Surgery Center Department of Hepatobiliary Surgery ⅡGuangdong Provincial Research Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280Guangdong ProvinceChina State Key Laboratory of Organ Failure Research Department of PathologyCancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of General Surgery&Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang HospitalFirst Clinical Medical SchoolSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijing 100853China State Key Laboratory of Organ Failure Research Southern Medical UniversityGuangzhou 510280Guangdong ProvinceChina

BACKGROUND immune cells,including neutrophils,natural killer(NK)cells,T cells,NKT cells and macrophages,participate in the progression of acute liver injury and hepatic *** date,there has been no systematic study on the quantitative changes in these different immune cells from initial injury to subsequent *** To investigate the infiltration changes of various immune cells in acute liver injury models over time,and to study the relationship between the changes in leukocyte cellderived chemotaxin 2(LECT2)and the infiltration of several immune *** Carbon tetrachloride-and concanavalin A-induced acute liver injury models were employed to mimic toxin-induced and autoimmune-mediated liver injury *** quantitative changes in various immune cells were monitored at different time *** samples were collected,and liver tissues were ***6G,CD161,CD4,CD8 and F4/80 staining were used to indicate neutrophils,NK/NKT cells,CD4^(+)T cells,CD8^(+)T cells and macrophages,***2-KO mice were used to detect the function of *** During the injury and repair process,different types of immune cells began to increase,reached their peaks and fell into decline at different time ***,when the serum alanine transaminase(ALT)and aspartate transaminase(AST)indices reverted to normal levels 7 d after the injury,the infiltration of immune cells still existed even 14 d after the injury,showing an obvious lag *** found that the expression of LECT2 was upregulated in acute liver injury mouse models,and the liver injuries of Lect2-KO mice were less severe than those of wild-type *** with wild-type mice,Lect2-KO mice had different immune cell *** The recovery time of immune cells was far behind that of serum ALT and AST during the process of liver ***2 could regulate monocyte/macrophage chemotaxis and might be used as a therapeutic target for acute liver injury.

关键词： immune cells Liver injury Liver repair Leukocyte cell-derived chemotaxin 2

Atherosclerosis and the role of immune cells

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World Journal of Clinical Cases 2015年第4期3卷 345-352页

作者： Fulya Ilhan Sevgi Tas Kalkanli Department of Immunology Faculty of Medicine University of Firat Department of Immunology Faculty of Medicine University of Dicle

Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis.

关键词： Atherosclerosis Inflammatory cytokines Pro-inflammatory mediators immune cells Adhesion molecules

immune cells in the B-cell lymphoma microenvironment:From basic research to clinical applications

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Chinese Medical Journal 2024年第7期137卷 776-790页

作者： Wenli Zhang Mengmeng Liu Wei Li Yongping Song Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology Henan Provincial Hematology HospitalZhengzhouHenan 450000China Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan 450052China Department of Research and Foreign Affairs The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenan 450008China

B-cell lymphoma is a group of hematological malignancies characterized by variable genetic and biological features and clinical *** tumor microenvironment(TME)is a complex network in tumors,which consists of surrounding blood vessels,extracellular matrix,immune and non-immune cells,and signaling *** evidence has shown that the TME,especially immune cells within,is a double-edged sword,acting either as a tumor killer or as a promoter of tumor *** pro-tumor activities are driven by subpopulations of immune cells that express typical markers but have unique transcriptional characteristics,making tumor-associated immune cells good targets for human anti-cancer therapy by ablating immunosuppressive cells or enhancing immune-activated ***,exploring the role of immune cells in the TME provides distinct insights for immunotherapy in B-cell *** this review,we elucidated the interaction between immune cells and tumor cells and their function in the initiation,progression,and prognosis of B-cell lymphoma,from preclinical experiments to clinical ***,we outlined potential therapeutic approaches and discussed the potential clinical value and future perspectives of targeting immune cells in patients with B-cell lymphoma.

关键词： Tumor microenvironment B-cell lymphoma immune cells Immunotherapy Targeted therapy

The Role of immune cells in Chronic HBV Infection

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Journal of Clinical and Translational Hepatology 2015年第4期3卷 277-283页

作者： Hai-Jun Li Nai-Cui Zhai Hong-Xiao Song Yang Yang An Cui Tian-Yang Li Zheng-Kun Tu Department of Translational Medicine The First HospitalJilin UniversityChangchunJilinChina

Hepatitis B virus(HBV)infection is a major cause of chronic liver diseases that may progress to liver cirrhosis and hepatocellular *** immune responses are important factors that determine whether HBV infection is cleared or *** infection,viral replication occurs inside hepatocytes,and the secretion of infectious virions can take place at high rates for ***,HBV DNA and viral proteins,like HBV early antigen(HBeAg)and HBV surface antigen(HBsAg),can be easily detected in *** infection with HBV is the result of an ineffective antiviral immune response towards the *** this review,we discuss the role of immune cells in chronic HBV infection.

关键词： immune cells Natural killer cells CD8+T cells Hepatitis B virus

The alteration of immune cells in the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

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Liver Research 2020年第1期4卷 23-27页

作者： Dechun Feng Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA

The prevalence of non-alcoholic fatty liver disease(NAFLD)increases rapidly in recent *** has become a major public health problem in China and the whole world,and it is considered as the main cause for the chronic liver ***,there is still not specific and effective treatment for non-alcoholic steatohepatitis(NASH),the advanced form of *** inflammation in the liver is the hallmark of ***,the dysregulation of immune cells happened in the early stage of *** immune cells in the liver may represent one of the effective ways for NASH treatment.A better understanding of the change of immune cells in the pathogenesis of NAFLD will be very helpful for developing new treatments for NAFLD and *** we summarized how the immune cells were affected in different stages of NAFLD and how these immune cells contributed to the development of NAFLD.

关键词： Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) immune cells Inflammation Fibrosis

RADIOIMMUNOTOXICOLOGICAL　EFFECT　OF　ENRICHED　URANIUM　ON　CENTRAL　AND　PERIPHERAL　immune　cells　AND　THE　PROTECTIVE　ACTION　OF　IL－1　AND　IL－2

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Nuclear Science and Techniques 1994年第2期5卷 93-99页

作者：朱寿彭赖冠华王六一 FacultyofRadiologicalMedicine SuzhouMedicalCollegeSuzhou215007China

Accumulation of enriched 235U-UO2F2 in the body had injurious effects on theimmune function of central and peripheral immune cells. After an intravenousinjection of beaU--UO,F,, the spontaneous ’H--TdR incorporation in thymocytes andbone marrow cells decreased, with the thymocytes damaged more markedly. Theproliferation ability of spleen T and B lymphocytes were both inhibited, with Blymphocytes inhibited more severely. In spleen B lymphocytes the IL-- 1 production andIL--2 consumption were diminished. The inhibition of spleen B lymphocyteproliferation by 'U-- UOZFZ was partially restored by adding exogenous IL-- 1 or IL--2to the cultured lymphocytes obtained from 'U injected mice.

关键词： Enriched uranium Radioimmunotoxicological effect Interleukin-1 Interleukin-2 immune cells Protective action