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Self-Reported Adherence after Overnight Switching from immediate- to Extended-release Pramipexole in Parkinson’s Disease

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Advances in Parkinson's Disease 2015年第1期4卷 13-19页

作者： Mutsumi Iijima Mikio Osawa Kenji Maruyama Shinichiro Uchiyama Kazuo Kitagawa Department of Neurology Tokyo Women’s Medical University School of Medicine Tokyo Japan

Background: Drug adherence decreased in patients with Parkinson’ s disease (PD) because of taking many different types of drugs. We evaluated drug adherence after switching from immediate-release (IR) to once-daily extended-release (ER) pramipexole (PPX) in PD. Methods: This study included 35 PD patients (20 men, 15 women);10 were taking oral PPX alone, and 25 were also using another anti-PD drug. PPX-IR was switched overnight to PPX-ER without gradual tapering. One month after switching, improvement in timing adherence and reduction in medication burden were evaluated by a questionnaire using a visual analog scale (VAS) (0: No change;10: Better). Motor function was assessed using part III of the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: The VAS score for improvement in timing adherence was 8.1 ± 0.5 (mean ± standard error), and that for reduction in medication burden was 7.3 ± 0.6. There was a significant negative correlation (ρ = -0.43, p = 0.01) between the VAS score and number of types of medications. The UPDRS part III score improved significantly after switching

关键词： Parkinson’s Disease Timing Adherence Pramipexole Extended-release immediate-release Motor Function

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The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 264-272页

作者： Qian Xiang Weidang Wu Nan Zhao Chuan Li Junyu Xu Lingyue Ma Xiaodan Zhang Qiufen Xie Zhuo Zhang Jiancheng Wang Weiren Xu Xia Zhao Yimin Cui Department of Pharmacy Peking University First HospitalBeijing 100034China State Key Laboratory of Drug release Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China School of Pharmaceutical Science Peking UniversityBeijing 100191China

The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin *** addition,we compared the fluvastatin pharmacokinetics differences between extended-release(ER)80 mg tablet and immediate-release(IR)40 mg capsule in terms of drug metabolism enzyme and transporter genetic *** this open-label,randomized,two-period,two-treatment,crossover study(n=24),effects of ABCG2,SLCO1B1,ABCB1,CYP2C9 and CYP3A5 polymorphisms on the pharmacokinetics of fluvastatin were *** administration dosage for IR 40 mg and ER 80 mg were twice and once daily,respectively,for total 7 *** samples for pharmacokinetic evaluation were taken on the 1st and 7th *** lower exposure following ER was *** ER tablets,SLCO1B1 T521C genotype correlated with AUC 0-24 of repeat doses(P=0.010).SLCO1B1 T521C genotype had no statistically significant effect on AUC 0-24 of IR capsule of fluvastatin after single or repeated *** vitro study demonstrated that when the concentration of fluvastatin was low(1μmol/l),transport velocity of fluvastatin by HEK293-OATP1B1 with SLCO1B1521TT(K m=11.4μmol/l)and with SLCO1B1521TCC(K m=15.1μmol/l)tend to be the *** suggests that the increased effect of SLCO1B1 T521C genotype on ER formulation of fluvastatin was mainly caused by lower blood *** recommend that formulation should be incorporated into future pharmacogenomics studies.

关键词： Genetic polymorphisms SLCO1B1 Fluvastatin immediate-release Extended-release

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