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Plasma 17-hydroxyprogesterone/cortisol ratio is not a predictor of systemic hypotension in extremely premature infants

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Open Journal of Pediatrics 2013年第2期3卷 78-84页

作者： Aurelie Lacoste Jean-Benoit Corcuff Antoine Benard Sandy Leproust Fabienne Nacka Olivier Brissaud Pascal Barat Département de Pédiatrie Endocrinologie PédiatriqueCentre Hospitalier Universitaire BordeauxBordeauxFrance Département de Médecine Nucléaire Centre Hospitalier Universitaire BordeauxBordeauxFrance Nutrition et Neurobiologie Intégrée Universitaire de BordeauxBordeauxFrance Pole de Sante Publique Centre Hospitalier Universitaire BordeauxBordeauxFrance Département de Pédiatrie Centre d’Investigation Clinique(CIC 0005)Centre Hospitalier Universitaire de BordeauxBordeauxFrance CHU de bordeaux Département de PédiatrieRéanimation PédiatriqueCentre Hospitalier Universitaire de BordeauxBordeauxFrance

Background/aims: To determine whether the 17-hydroxyprogesterone (17-OHP)/cortisol ratio as a marker of immature11-beta hydroxylase activity can predict severe systemic hypotension in preterm neonates. Methods: Serum cortisol and 17-OHP concentrations were measured in capillary blood deposited on blotter paper on day 3 post-natal age (Day 3) in infants less than 32 weeks postmenstrual age (PMA). The predictive value of 17-OHP/cortisol ratio for a first episode of systemic hypotension occurring after Day 3 (FESH) was evaluated. Results: Of 105 infants included, 14 patients (13%) presented a FESH. Neither the 17-OHP/cortisol ratio, nor the 17-OHP or cortisol concentrations were associated with the occurrence of a FESH when adjusted for potential confounding factors. 17-OHP and cortisol were inversely associated to PMA (r = ﹣0.36 and ﹣0.40, respectively). Cortisol, but not 17-OHP, was associated with the type of hospitalization unit, the respiratory support and the presence of a patent ductus arteriosus. The 17-OHP/cortisol ratio was associated with the type of hospitalization unit only. Conclusions: The 17-OHP/ cortisol ratio at Day 3 did not predict the occurrence of a first episode of systemic hypotension after Day3 inpreterm neonates.

关键词： Relative Adrenal Insufficiency immaturity Congenital Adrenal Hyperplasia Screening Program

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Research on the Educational Issues of the Emerging Tourism Industry in Developing Countries

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Journal of Contemporary Educational Research 2021年第12期5卷 17-23页

作者： Chao Feng Di Wu Business School Xiangtan Institute of TechnologyXiangtan 411104China

This research explores emerging concepts of tourism education,training,and entrepreneurship ***,the discourses on this theme have been growing in both developed and developing countries,especially to reduce unemployment rates through the education of young *** this purpose,this study uses secondary data sources to analyze individual rationality and the creativity of educated young people for entrepreneurship development in the business *** analytical framework begins from the investigation of the tourism industry and the processes for empowering those people since tourism industry is considered as one of the agents of economic changes in developing countries,such as ***,skilled and trained manpower are required to operate *** main theme of this study is that the aforesaid manpower can be developed with entrepreneurship skills by providing education and training in this *** study entirely agrees that once the tourism industry is well run by removing the hurdles seen in this sector,there would be an increase in employment opportunities and a raise in the country’s revenue in addition to solving many other social problems.

关键词： Tourism industry Diversity immaturity Entrepreneurship Education Training

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