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image-guided lens extraction surgery: a systematic review

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 135-151页

作者： Eirini-Kanella Panagiotopoulou Panagiota Ntonti Maria Gkika Aristeidis Konstantinidis Irfan Perente Doukas Dardabounis Konstantinos Ioannakis Georgios Labiris Department of Ophthalmology University Hospital of Alexandroupolis

A systematic review of the recent literature regarding the current image-guided systems used for cataract surgery or refractive lens exchange was performed based on the PubMed and Google Scholar databases in March 2018. Literature review returned 21 eligible studies. These studies compared image-guided systems with other keratometric devices regarding their accuracy, repeatability and reproducibility in measurement of keratometric values, astigmatism magnitude and axis, as well as in IOL power calculation. Additionally, the image-guided systems were compared with conventional manual ink-marking techniques for the alignment of toric IOLs. In conclusion, image-guided systems seem to be an accurate and reliable technology with measurements of high repeatability and reproducibility regarding the keratometry and IOL power calculation, but not yet interchangeable with the current established and validated keratometric devices. However, they are superior over the conventional manual inkmarking techniques for toric IOL alignment.

关键词： image-guided systems cataract surgery toric intraocular lenses systematic review

Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy

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Nuclear Science and Techniques 2017年第5期28卷 95-99页

作者： Chu-Feng Jin Hui Liu Wen-Yi Li Rui-Fen Cao School of Nuclear Science and Technology University of Science and Technology of China Key Laboratory of Neutronics and Radiation Safety Institute of Nuclear Energy Safety TechnologyChinese Academy of Sciences

image-guided radiotherapy(IGRT) provides precise positioning for the tumor target, but it may bring extra irradiation dose in the target positioning with a cone beam CT(CBCT) which has been increasingly used in IGRT. In this work, we focused on biological effects of the low-dose irradiation in IGRT, which have not been considered so far. Primary human fibroblasts cells from the lung and MRC-5 were irradiated by a CBCT. DNA doublestrand breaks(c-H2 AX foci) and micronucleus frequency of the irradiated samples were analyzed. Compared to the control, the c-H2 AX foci yields of the samples irradiated to 16 m Gy increased significantly, and the micronuclei rate of the samples irradiated for 3 days increased notably. The dose by imaging guidance device can be genotoxic to normal tissue cells, suggesting a potential risk of a secondary cancer. The effects, if confirmed by clinical studies,should be considered prudentially in designing IGRT treatment plans for the radiosensitive population, especially for children.

关键词： image-guided radiotherapy Cone beam CT Imaging irradiation Biological effects Secondary cancer

Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

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Science China(Life Sciences) 2019年第11期62卷 1472-1480页

作者： Xiaoyan Zhang Cong Li Wenyi Liu Hanlin Ou Dan Ding Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Tianjin Stomatological Hospital Hospital of StomatologyMedical CollegeNankai UniversityTianjin 300041China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhou 221002China

Aggregation-induced emission(AIE)nanoparticles(NPs)are widely used for image-guided tumor resection because of their high signal-to-noise ratios and long systemic circulation *** NPs are derived by encapsulating small-molecule fluorescent dyes with AIE property inside the cores of NPs assembled by amphiphilic *** the systemic circulation of AIE NPs is prolonged,hydrophilic polymer coatings simultaneously decrease the binding and uptake of AIE NPs by tumor *** overcome this problem,surface-adaptive AIE dye-encapsulated mixed-shell micelles(MSMs)with polyethylene glycol/poly(β-amino ester)(PEG/PAE)surfaces were *** to the charge conversion ability of PAE,MSMs demonstrated enhanced cellular uptake by tumor cells in acidic *** addition,compared with single-PEG-shelled micelles(PEGSMs),MSMs exhibited prolonged systemic circulation due to the presence of micro-phase separated ***,due to the coordination effect of enhanced cancer cell uptake and prolonged systemic circulation time,MSMs were more enriched than PEGSMs in the tumor cells and exhibited excellent performance during image-guided tumor resection.

关键词： aggregation-induced emission surface-adaptive enhanced cellular uptake image-guided tumor resection

A novel technique for sacropelvic fixation using image-guided sacroiliac screws:a case series and biomechanical study

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The Journal of Biomedical Research 2019年第3期33卷 208-216页

作者： Kee D.Kim Huy Duong Aditya Muzumdar Mir Hussain Mark Moldavsky Bandon Bucklen Department of Neurological Surgery University of California Davis Department of Neurosurgery Kaiser Permanente Medical Group Musculoskeletal Education and Research Center(MERC) Globus Medical Inc

In this study, we sought to assess the safety and accuracy of sacropelvic fixation performed with image-guided sacroiliac screw placement using postoperative computed tomography and X-rays. The sacroiliac screws were placed with navigation in five patients. Intact specimens were mounted onto a six-degrees-of-freedom spine motion simulator. Long lumbosacral constructs using bilateral sacroiliac screws and bilateral S1 pedicle and iliac screws were tested in seven cadaveric spines. Nine sacroiliac screws were well-placed under an image guidance system(IGS);one was placed poorly without IGS with no symptoms. Both fixation techniques significantly reduced range of motion(Pimage guidance improves its safety and accuracy. This new technique of image-guided sacroiliac screw insertion should prove useful in many types of fusion to the sacrum, particularly for patients with poor bone quality,complicated anatomy, infection, previous failed fusion and iliac harvesting.

关键词： lumbosacral fixation sacropelvic fixation sacroiliac screw computer-assisted surgery image-guided surgery

Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis

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Journal of Interventional Medicine 2018年第3期1卷 150-156页

作者： Peng Hu Jihong Sun Fangfang Lv Borui Pi Fangping Xu Guocan Han Xi Hu Yue Wang Ning Huang Xia Wu Xiaoming Yang Department of Radiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Infectious Diseases Sir Run Run Shaw Hospital Zhejiang University School of Medicine GE Healthcare image-guided Bio-Molecular Interventions Research Department of Radiology University of Washington School of Medicine

Purpose To evaluate the performance of diffusion-weighted imaging(DWI) and variable flip angle(VFA) T1 mapping as a supplement to image-guided biopsy in follow-up analysis of liver fibrosis. Materials and Methods This prospective study was approved by the institution's committee on human research, and written informed consent was provided from the enrolled patients. We investigated five MRI parameters of DWI and VFA T1 mapping, collected from 11 patients who underwent serial ultrasound image-guided biopsy with follow-up MRI within 1.5 years after treatment for liver fibrosis/cirrhosis. For each patient, four consecutive MRI examinations were conducted, including baseline MRI before treatment and three follow-up MRI examinations after treatment at each 0.5-year interval. ADC values at four b values and T1 relaxation times were correlated to pathology-confirmed liver fibrosis stages, which were subsequently divided into two groups, stages F2–3 and F4. The receiver operating characteristic(ROC) analysis and repeated measurement analysis of variance were used for statistical analysis. Results Among these ADC parameters, ADC value(b = 500 s/mm^2) was the most consistent in differentiating between stage F2–3 and F4 liver fibrosis. Repeated measurement analysis showed that the intra-group and inter-group differences were 0.447 and 0.024, respectively. T1 relaxation time could not consistently differentiate between the F2–3 and F4 groups; however, it was repeatable, and the intra-group and inter-group differences were 0.410 and 0.042, respectively. Conclusion MRI-ADC value at a b value of 500 s/mm^2 can be a promising biomarker for differentiating stages F2–3 and F4 liver fibrosis. A combination of this biomarker with repeatable T1 relaxation time may function as a non-invasive tool for follow-up liver fibrosis in patients who reject repeated image-guided biopsy.

关键词： image-guided biopsy,MRI T1 mapping diffusion-weighted imaging

The Associations for Vaginal Point Doses of Vaginal Stenosis in image-guided Brachytherapy

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Journal of Cancer Therapy 2014年第9期5卷 823-829页

作者： Ekkasit Tharavichitkul Rungtip Jayavasti Razvan M. Galalae Damrongsak Tippanya Sukon Prasitwattanaseree Wannapa Nobnop Somvilai Chakrabandhu Pitchayaponne Klunklin Wimrak Onchan Somsak Wanwilairat Imjai Chitapanarux Faculty of Medicine Christian-Albretch University Kiel Germany Science and Technology Research Institute Chiang Mai University Chiang Mai Thailand The Division of Therapeutic Radiology and Oncology Faculty of Medicine Chiang Mai University Chiang Mai Thailand

Purpose: To evaluate the associations for vaginal dose points of vaginal stricture in image-guided brachytherapy. Materials and Methods: Twenty-six patients of locally advanced cervical cancer were treated with image-guided Brachytherapy (IGBT) with the dose at least 7 Gy per fraction to the D90 of High-Risk Clinical Target Volume (HR-CTV). The vaginal dose points of recommendations of the American Brachytherapy Society (ABS) were added into the plan and cumulative dose to these points was evaluated in Equivalent Dose of 2 Gy (EQD2) concepts. Results: The mean doses to right vaginal dose point (VR), left vaginal dose point (VL) and average dose of VR/VL ((VR + VL)/2) were 101.5 Gy, 98.2 Gy and 99.8 Gy in EQD2 concepts, respectively. Volume-based planning significantly reduced the cumulative dose in EQD2 concepts at vaginal points. At the median follow-up time of 22 months, grade-2 vaginal stricture was observed in two patients. The incidences of vaginal stricture were not differed between the cumulative dose to vaginal dose points in EQD2 concepts of ≤90 Gy versus >90 Gy (P = 1.000) and ≤100 Gy versus >100 Gy (P = 0.815). Conclusion: No association for cumulative vaginal doses and events of vaginal stricture was found.

关键词： image-guided Brachytherapy Vaginal Dose Point Vaginal Stricture Associations

REPRODUCIBILITY OF INTER-FRACTIONAL LIVER POSITION USING ACTIVE BREATHING COORDINATOR IN image-guided INTENSITY-MODULATED RADIOTHERAPY OF HEPATIC CANCER

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REPRODUCIBILITY OF INTER-FRACTIONAL LIVER POSITION USING ACT...

A NIR-Ⅱ theranostics nanoprobe for tumor diagnosis and image-guided therapy

中华医学会放射肿瘤治疗学分会六届二次暨中国抗癌协会肿瘤放疗专业委员会二届二次学术会议

作者： LOI CHOWMING Department of Radiation Oncology AmMed Cancer Center

Background and Objective:Geometric uncertainties resulted from treatment positioning variation and respiratory motion limit the precision of intensity-modulated radiotherapy(IMRT) for hepatic cancer,which could substantially lead to an increased volume of irradiated normal *** breathing control(ABC) is a promising and effective method to immobilize the liver by minimizing the breathing motion during a course of *** with the kilovoltage(KV) cone-beam computed tomography(CBCT) technology,high precision hepatic cancer IMRT could be realized using the ABC *** aim of this study is to evaluate the inter-fractional reproducibility of the liver position using an active breathing coordinator in patients with unresectable hepatic carcinoma treated with IMRT under the guidance of CBCT technology. Materials and Methods:Twelve patients with unresectable intrahepatic tumors who could comfortably hold their breath for at least 25 seconds were recruited in this study.A contrast-enhanced computed tomography(CT) scan was acquired at end-inhalation breath hold with the aid of the *** liver was delineated on the planning CT slices and functioned as a reference for image guidance.A full rotation of KV CBCT scan was acquired after patient *** contour matching of the actual liver structure from the planning CT with the CBCT was *** translational errors in three dimensions(3D) were corrected ***-correction CBCT was then acquired to evaluate the residual correction errors after the initial *** KV portals were acquired to evaluate the accuracy of the manual contour match *** CBCT slices were also exported back to the treatment planning system to evaluate dosimetrically the accuracy of the manual contour match results as a function of dose-volume *** inter-fractional reproducibility of the liver position using ABC was evaluated. Results:A total of 700 CBCT(pre- and post-correction) and 7

关键词： image-guided Active Breathing Coordinator(ABC) Intensity-Modulated Radiotherapy(IMRT) Hepatic Cancer Matching

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Science Foundation in China 2019年第1期27卷 23-23页

With the support by the National Natural Science Foundation of China and the National Key R&.D Program,the research team led by *** Yao,*** HaiBing and *** GuangFu(杨光富)at the Laboratory of Pesticide *** *** of Education,Central China Normal University,cooperated with the research team led by *** *** from the University of Utah,and developed a novel NIR-II nanoprobe for tumor diagnosis and evaluation of anti-tumor efficiency.

关键词： A NIR-II theranostics nanoprobe tumor diagnosis image-guided therapy

Hi'CT:a pixel sensor-based device for ion tomography

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Nuclear Science and Techniques 2023年第7期34卷 231-241页

作者： Yi-Lun Chen Hong-Kai Wang Shi-Yu Zhang Hai-Bo Yang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516003China

Carbon ions,commonly referred to as particle therapy,have become increasingly popular in the last *** predicting the range of ions in tissues is important for the precise delivery of doses in heavy-ion *** uncertainty is currently the largest contributor to dose uncertainty in normal tissues,leading to the use of safety margins in treatment *** potential method is the direct relative stopping measurement(RSP)with ***-ion CT(Hi′CT),a compact segmented full digital tomography detector using monolithic active pixel sensors,was designed and evaluated using a 430 MeV/u high-energy carbon ion pencil beam in *** precise position of the individual carbon ion track can be recorded and reconstructed using a 30μm×30μm small pixel pitch *** types of customized image reconstruction algorithms were developed,and their performances were evaluated using three different modules of CAT-PHAN 600-series *** RSP measurement accuracy of the tracking algorithm for different types of materials in the CTP404 module was less than 1%.In terms of spatial resolution,the tracking algorithm could achieve a 20%modulation transfer function normalization value of CTP528 imaging results at 5 lp/cm,which is significantly better than that of the fast imaging algorithm(3 lp/cm).The density resolution obtained using the tracking algorithm of the customized CTP515 was approximately 10.5%.In conclusion,a compact digital Hi'CT system was designed,and its nominal performance was evaluated in a *** RSP resolution and image quality provide potential feasibility for scanning most parts of an adult body or pediatric patient,particularly for head and neck tumor treatment.

关键词： Heavy-ion imaging Computed tomography Silicon pixel detectors Monte Carlo Phantoms Radiotherapy image-guided Tracking