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The effect of lithium chloride on morphine-induced tolerance and dependence in isolated guinea pig ileum.

The effect of lithium chloride on morphine-induced tolerance...

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第十五届国际药理学大会

作者： Alborzi A Ejtemaei Mehr Sh Rezania,F Badakhshan S. Mombeini T. Shafaroodi H. Nick Ravan M.R Sharifian,M Dehpour A.R. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Shahed University Tehran Iran. Department of Pharmacology Tehran Medical Unit Islamic Azad University Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran. Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran.

＜正＞ The aim of the present study was to investigate the effect of lithium on acute morphine - induced tolerance and dependence in an in vitro model of isolated guinea pig ileum which has been extensively used for the assessment of these effects of o pioids. Morphine inhibited electrically stimulated twitch of ileum in a concentration - dependent manner （pD2 = 7.27±0.16）. Tolerance to this effect was induced by incubation of ileum with 2 × IC50 of morphine for 2 h that induced a degree of tolerance of 14. 7. The co - incubation of ileum with morphine along lithium chloride （1mM） reduced the degree of tolerance significantly （P ＜ 0.001） and restored the sensitivity of ileum to the morphine inhibitory effect. Lithium chloride can also reduce the expression of tolerance to morphine significantly （p ＜ 0.01）. Dependence was induced by incubation with 4 × IC50 of morphine for 2 h and was assessed based on naloxone- induced contractions （10-5 M）. Lithium chloride （1mM） can attenuate the development but not expression of dependence to morphine as shown by the significant decrease in naloxone - induced contractions （P ＜ 0.05）. These results suggest that lithium chloride can reduce the development and expression of acute tolerance to and development of dependence on morphine in the myenteric plexus of guinea pig ileum.

关键词： ileum, guinea pig Tolerance Dependence Morphine Lithium

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