检索结果-南通市图书馆

Correction:Cognitive Impairment in idiopathic normal pressure hydrocephalus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第9期38卷 1121-1122页

作者： Haoyun Xiao Fan Hu Jing Ding Zheng Ye Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Department of Neurosurgery Zhongshan HospitalFudan UniversityShanghai200032China Department of Neurology Zhongshan HospitalFudan UniversityShanghai200032China

idiopathic normal pressure hydrocephalus (iNPH) is a significant cause of the severe cognitive decline in the elderly population. There is no cure for iNPH, but cognitive symptoms can be partially alleviated through cerebrospinal fluid (CSF) diversion. In the early stages of iNPH, cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits. As the disease progresses, cognition declines continuously and globally, leading to poor quality of life and daily functioning. In this review, we present recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH, focusing on (1) abnormal CSF dynamics, (2) dysfunction of frontostriatal and entorhinal-hippocampal circuits and the default mode network, (3) abnormal neuromodulation, and (4) the presence of amyloid-β and tau pathologies.

关键词： idiopathic normal pressure hydrocephalus Cognitive impairment Cerebrospinal fluid dynamics Frontostriatal circuits Entorhinal-hippocampal circuits Neuromodulation Amyloid-β pathology Tau pathology

Radiological biomarkers of idiopathic normal pressure hydrocephalus:new approaches for detecting concomitant Alzheimer’s disease and predicting prognosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psychoradiology 2022年第4期2卷 156-170页

作者： Hanlin Cai Yinxi Zou Hui Gao Keru Huang Yu Liu Yuting Cheng Yi Liu Liangxue Zhou Dong Zhou Qin Chen Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Neurosurgery West China Hospital of Sichuan UniversityChengduSichuan 610041China

idiopathic normal pressure hydrocephalus(iNPH)is a clinical syndrome characterized by cognitive decline,gait disturbance,and urinary incontinence.As iNPH often occurs in elderly individuals prone tomany types of comorbidity,a differential diagnosis with other neurodegenerative diseases is crucial,especially Alzheimer’s disease(AD).A growing body of published work provides evidence of radiological methods,including multimodal magnetic resonance imaging and positron emission tomography,which may help noninvasively differentiate iNPH from AD or reveal concurrent AD pathology in vivo.Imaging methods detecting morphological changes,white matter microstructural changes,cerebrospinal fluid circulation,and molecular imaging have been widely applied in iNPH patients.Here,we review radiological biomarkers using different methods in evaluating iNPH pathophysiology and differentiating or detecting concomitant AD,to noninvasively predict the possible outcome postshunt and select candidates for shunt surgery.

关键词： idiopathic normal pressure hydrocephalus Alzheimer’s disease radiological biomarker magnetic resonance imaging positron emission tomography

Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroimmunology and Neuroinflammation 2020年第2期7卷 109-119页

作者： Xin-Jie Zhang Jian Guo Jun Yang Department of Neurosurgery Xiang'an Hospital of Xiamen University School of Medicine Xiamen University Xiamen 361102 Fujian China

idiopathic normal pressure hydrocephalus (iNPH) is characterized by abnormal cerebrospinal fluid (CSF) flow and consequent cerebral ventricular enlargement due to imbalance of CSF production and absorption. The typical triad symptoms, namely cognitive decline, gait disturbance, and urinary incontinence, are thought to be caused by disruption of CSF circulation. However, some patients may still experience symptomatic progression after functional shunting, suggesting that iNPH is far more complicated than a simple disorder of CSF circulation. Moreover, the diagnostic workup of iNPH can be challenging due to symptomatic and neuroimaging overlaps with other neurological disorders, such as Alzheimer's disease. Furthermore, accumulating studies indicate that the pathogenesis of iNPH might relate to multiple mechanisms, including abnormalities of brain development, brain extracellular matrix, synaptic function, blood flow, and cerebral metabolism. Therefore, iNPH is not an isolated entity in occurrence and development. Nevertheless, different pathogeneses may result in protein content changes in CSF, and the biomarkers in CSF may reflect the possible mechanisms involving the etiology of iNPH and are potentially useful in assisting the diagnosis and treatment selection. In this review, we summarize the main findings of CSF biomarkers and aim to outline a possible synthetic profile in assisting iNPH diagnosis and therapeutic options.

关键词： idiopathic normal pressure hydrocephalus cerebrospinal fluid biomarkers neurodegenerative diseases

Management of idiopathic Chronic hydrocephalus of the Adult in Guinea: A Prospective Study in 16 Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2021年第4期11卷 272-280页

作者： Alpha Boubacar Bah Ibrahima Sory Souare Ibrahima Berete Seylan Diawara Hugues Ghislain Atatla Aboubacar M’mah Camara Mamadou Khaira Bah Luc Kezely Beavogui Service de Neurochirurgie H&#244 pital National Donka Conakry Guinea Service de Neurochirurgie H&#244 pital de l’Amitié Sino-Guinéenne de Kipé Conakry Guinea

Object: Incidence of idiopathic chronic hydrocephalus of the adult (ICHA) is increasing in Guinea due to the aging of the population. The goal of this study was to describe its epidemiology, clinical presentation, and... 详细信息

Object: Incidence of Idiopathic chronic hydrocephalus of the adult (ICHA) is increasing in Guinea due to the aging of the population. The goal of this study was to describe its epidemiology, clinical presentation, and surgical outcome in a low-resource medical environment. Method: Sixteen patients operated for a probable ICHA were prospectively studied according to a uniform protocol from June 2019 to December 2020. On computerized tomography, all operated patients had a clinical triad of gait disturbance, incontinence, dementia associated with ventriculomegaly, and transependymal edema. In addition, all patients underwent a single lumbar tap, improved clinically, and were subsequently offered a shunt consisting of a simple catheter in 37.5% and a non-adjustable high-pressure valve in 62.5%. Result: The mean age was 68.31 ± 10.4 (range 49 - 89). The sex ratio H/F was 1.67/1. Clinically, the most frequent comorbidity was a combination of hypertension and diabetes in 56.5% of cases. The mean time to diagnosis was 8.31 ± 2.75 months (range 3 - 14). The immediate postoperative mortality was 12.5% from a status epilepticus and pulmonary sepsis. In addition, we observed 2 cases of chronic subdural hematoma (12.5%) and 2 cases of shunt dysfunction