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idiopathic hirsutism:Is it really idiopathic or is it misnomer?

World Journal of Clinical Cases 2023年第2期11卷 292-298页

作者： Kursad Unluhizarci Aysa Hacioglu Serpil Taheri Zuleyha Karaca Fahrettin Kelestimur Department of Endocrinology Erciyes University Medical SchoolKayseri 38039Turkey Department of Medical Biology Erciyes University Medical SchoolKayseri 38039Turkey Department of Endocrinology Yeditepe University Medical SchoolIstanbul 34755Turkey

hirsutism,which is characterized by excessive growth of terminal hair in a male pattern,may result from various causes including polycystic ovary syndrome(PCOS),non-classic congenital adrenal hyperplasia,adrenal or ovarian tumors or it may be *** hirsutism is currently defined as hirsutism associated with normal ovulatory function,normal serum androgen levels and normal ovarian morphology,however,the pathogenesis of idiopathic hirsutism is not *** androgens are the main hormones to stimulate growth of body hair,therefore,there should be any form of increased androgen effect irrespective of normal serum androgen levels in any patient with *** accordance to this scientific truth,we have previously shown that,although within normal limits,patients with idiopathic hirsutism have relatively higher serum androgen levels(relative hyperandrogenemia)in comparison to healthy subjects which let as to think that is idiopathic hirsutism really idiopathic?In addition to relative hyperandrogenemia,we have previously shown that,in comparison to healthy subjects,women with idiopathic hirsutism demonstrated higher expression of steroid sulphatase and 17-beta hydroxysteroid dehydrogenase mRNA both in the subumbilical region and arm skin,which contributes to local androgen *** results support the idea that,in some patients,although the adrenals or ovaries do not secrete increased amount of androgens leading to hyperandrogenemia,pilocebaceous unit locally produce increased amount of androgens leading to hirsutism without ovulatory *** the demonstration of relative hyperandrogenemia and possible increase in local androgen synthesis in patients with idiopathic hirsutism,we think that idiopathic hirsutism is not idiopathic and it may be named as“normoandrogenic hirsutism”.Furthermore,it may not be a different entity but may be an early stage of hyperandrogenic disorders such as ***,this can be find out by following-up p

关键词： idiopathic hirsutism Normoandrogenic hirsutism Hyperandrogenemia Androgen excess disorders

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