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Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the icr mice(Mus musculus)

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Asian Pacific Journal of Tropical Biomedicine 2016年第2期6卷 155-158页

作者： Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor Ⅱ Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma.Caterial Paano Biology Department College of Science De La Salle University Chemistry Department College of Science De La Salle University

Objective: To examine the anti-hyperglycemic effects of aqueous Lenzites betulina(L. betulina) extracts on normoglycemic glucose-loaded ***: Different doses of aqueous extract from L. betulina were administered to 45 icr mice(Mus musculus) to determine whether there was an effect of L. betulina extracts on the blood glucose level of the icr mice. Aqueous extracts of L. betulina were orally gavaged to mice using oral glucose tolerance test. A total of five groups were used to determine the effect of the fungi on blood glucose of the mice. Group A(positive control)was given 16.7 mg/kg glimepiride; Group B(negative control) was given distilled water;Group C(low dosage) was given 200 mg/kg aqueous extract; Group D(mid dosage) was given 400 mg/kg aqueous extract and Group E(high dosage) was given 800 mg/kg aqueous extract. Baseline blood glucose value was firstly acquired before induction of hyperglycemia through D-glucose, after which another check on blood glucose was made after 0.5 h. Immediately, after the acquisition of hyperglycemic blood glucose level, the individual administration of treatments were done. After that, three blood collections were done spanning 3 h with 1 h ***: The low dose(200 mg/kg) and the mid dose(400 mg/kg) of L. betulina extracts were significantly different(P 0.05) from its corresponding baseline value, acting faster than the positive control(glimepiride), which only became significantly different(P < 0.05) at the 2nd ***: Aqueous L. betulina extract is able to produce hypoglycemic effects on the mice with all doses, which are able to normalize blood glucose levels at varying times.

关键词： Anti-hyperglycemic Glucose Lenzites betulina icr mice Oral Glucose tolerance test

Hematological effects of Ipomoea batatas(camote) and Phyllanthus niruri(sampa-sampalukan) from Philippines in the icr mice(Mus musculus)

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 29-33页

作者： Jessa Fidel Montejo Juan Arturo Burgos Mondonedo Matthew Genesis Aguila Lee Michael Bagui Ples Rodel Jonathan Santos Vitor Ⅱ Biology Department College of ScienceDe La Salle University

Objective:To analyze the hematological effects of administering Ipomoea batatas(***)and Phyllanthus niruri(***) in the icr ***:Powdered leaves of /.batatas and *** were fed to mice for 4 weeks.A total of six groups were used to determine the effect of the plants to the complete blood count of the *** A(blank control) mice were feed with pellets only;Group B(negative control) mice were fed with pellets coated with honey;Group C(low dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 10 g/kg body weight of the mouse;Group D(high dosage) mice were fed with honey-coated pellets and powdered leaves of I,batatas at 20 g/kg body weight of the mouse;Group E(low dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 10 g/kg body weight of the mouse:and Group F(high dosage) mice were fed with honey-coated pellets and powdered leaves of *** at 20 g/kg body weight of the *** blood count was performed on Days 0.14 and ***:It was shown that *** can increase the values of hematocrit and hemoglobin on both the low dose and high dose at Day 28 and red blood cells(RBC) on both Days 14 and28 of *** the other *** can increase *** and hemoglobin on Day 28 with only the low *** were no significant differences with white blood cell,absolute granulocyte,lymphocyte and monocyte,and platelet counts observed for both plant ***:*** and *** have effects on the hematocrit,RBC and hemoglobin levels in mice.

关键词： Camote Hematology icr mice Ipomea batatas Phyllanthus niruri Sampa-sampalukan

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icr进展及关键技术

热能动力工程 1999年第6期14卷 415-418页

作者：刘永葆张仁兴解放军海军工程学院305教研室湖北武汉 43 0 0 3 3

icr燃气轮机继承了简单循环燃气轮机的一系列优点,且具有优良的变工况性能。WR-21代表了icr的最先进水平。本文简述了WR-21燃气轮机的最新进展,对中冷器、回热器、箱装体、数字控制系统等重要部件的关键技术进行了分析。

关键词： icr 燃气轮机中冷器回热器箱装体控制系统

基于傅里叶变换离子回旋共振质谱仪(FT icr MS)的超宽波段光解离光谱系统的研制及应用

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质谱学报 2020年第2期41卷 181-190,I0008页

作者：张凯林周敏石莹莹马利福李树奇汪曣孔祥蕾南开大学化学学院元素有机化学国家重点实验室天津300071 天津大学精密仪器与光电子工程学院天津300072 安徽师范大学物理与电子学院安徽芜湖241000 南开大学化学科学与工程创新中心天津300071

基于质谱技术的光解离光谱方法具有灵敏度高和可行性好的优势,近年来在气相离子化学和分析化学研究领域得到了快速发展和广泛应用。本工作基于一台7 T的傅里叶变换离子回旋共振质谱仪(FT icr MS),搭建了超宽波段的可调谐激光光路系统,... 详细信息

基于质谱技术的光解离光谱方法具有灵敏度高和可行性好的优势,近年来在气相离子化学和分析化学研究领域得到了快速发展和广泛应用。本工作基于一台7 T的傅里叶变换离子回旋共振质谱仪(FT icr MS),搭建了超宽波段的可调谐激光光路系统,获得了气相离子超宽波段的光解离光谱。该系统的光谱可调谐范围为192~3 700 nm,是目前已知在单台质谱仪上可获得最宽波段的光解离光谱系统。超宽波段的波长覆盖范围使用两台宽波段可调谐OPO激光器实现,光路可以在真空传输,提高了紫外和红外激光的传输效率。该系统结合了电喷雾(ESI)电离源和FT icr MS的高分辨能力以及超强的离子操控能力,可以获得目标离子的紫外-可见光以及中红外区域的光解离光谱,分别对应于分子的电子和振动能级,实现了分子结构信息的互补。以罗丹明110和色胺为例,获得了相应的离子在不同波段中的光解离光谱,初步证明了该仪器实现相关功能的可行性。

关键词：光解离光谱可调谐激光傅里叶变换离子回旋共振质谱仪(FT icr MS) 罗丹明色胺

Immunophenotype and differentiation capacity of bone marrow-derived mesenchymal stem cells from CBA/Ca,icr and Balb/c mice

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World Journal of Stem Cells 2013年第1期5卷 34-42页

作者： Yin Yin Ooi Zul'atfi Rahmat Shinsmon Jose Rajesh Ramasamy Sharmili Vidyadaran Department of Pathology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangMalaysia Department of Anatomy Yong Loo Lin School of MedicineNUSMD104 Medical DriveSingapore 117597Singapore

AIM:To assess the capacity to isolate and expand mesenchymal stem cells(MSC)from bone marrow of CBA/Ca,icr and Balb/c mice. METHODS:Bone marrow of tibia and femur were flushed,cultured and maintained in supplemented Dulbecco’s modified Eagle’s *** immunophenotype of cultures were tracked along increasing passages for positivity to CD106,Sca-1 and CD44 and negativity to CD45,CD11b and MHC classⅡ.Differentiation capacity of MSC towards osteogenic and adipo-genic lineages were also assessed. RESULTS:MSC were successfully cultured from bone marrow of all 3 strains,albeit differences in the temporal expression of certain surface *** differentiation into osteocytes and adipocytes were also observed. MSC from all 3 mouse strains demonstrated a shift from a haematopoietic phenotype(CD106-CD45+CD11b+Sca-1low)to typical MSC phenotype(CD106+CD45-CD11b-Sca-1high)with increasing passages. CONCLUSION:Information garnered assists us in the decision of selecting a mouse strain to generate MSC from for downstream experimentation.

关键词： Mesenchymal stem cells Mouse bone marrow CBA/Ca strain icr strain Balb/c strain Immunophenotyping Differentiation

C57BL/6和icr品系小鼠在大脑中动脉栓塞(MCAO)模型中差异的研究

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世界科学技术-中医药现代化 2022年第5期24卷 1925-1932页

作者：郑晓宇宋文婷李磊曹慧姚明江刘建勋中国中医科学院西苑医院基础医学研究所/北京市中药药理重点实验室北京100091 北京中医药大学临床医学院西苑医院北京100029

目的探讨C57BL/6与icr小鼠在大脑中动脉栓塞模型(middle cerebral artery occlusion,MCAO)中的品系间差异。方法设C57BL/6正常组和icr正常组为5只,C57BL/6模型组和icr模型组分别设10只,模型组采用相同的MCAO方法进行造模,观察每组小... 详细信息

目的探讨C57BL/6与icr小鼠在大脑中动脉栓塞模型(middle cerebral artery occlusion,MCAO)中的品系间差异。方法设C57BL/6正常组和icr正常组为5只,C57BL/6模型组和icr模型组分别设10只,模型组采用相同的MCAO方法进行造模,观察每组小鼠体重变化率、神经行为学、脑指数、脑含水量、脑梗死面积、生存率。结果 (1)C57BL/6与icr小鼠分别于术前和脑缺血后24 h进行统计,体重变化率具有显著的统计学差异(Picr小鼠的生存率分别为90.91%和72.72%;(3)C57BL/6与icr小鼠的神经行为学评分无显著的统计学差异;(4)C57BL/6与icr小鼠的脑指数分别为1.91%±1.34%、2.06%±1.76%,两组间的差异具有统计学意义(Picr小鼠的脑含水量分别为82.32%±1.34%、85.83%±1.76%,两组间具有显著的统计学差异(Picr小鼠的脑梗死面积分别为13.85%±4.32%、28.18%±8.29%,两组间具有显著的统计学差异(Picr小鼠间存在较为显著的品系间差异。

关键词：小鼠大脑中动脉栓塞模型 C57BL/6 icr 品系间差异

血清LncRNA HOTAIR、BRM、icr在肝癌诊断中的价值及与中医证型相关性的临床研究

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血清LncRNA HOTAIR、BRM、ICR在肝癌诊断中的价值及与中医证型相...

作者：苏晓倩浙江中医药大学

学位级别：硕士

目的探究血清LncRNA HOTAIR、LncBRM、icr在健康人、肝硬化患者及分期不同的PLC患者血清中的表达情况,比较LncRNAHOTAIR、lncBRM、icr与AFP在PLC患者血清表达敏感度与特异度差异,进一步补充和完善血清lncRNAs在原发性肝癌中的早期诊断... 详细信息

目的探究血清LncRNA HOTAIR、LncBRM、icr在健康人、肝硬化患者及分期不同的PLC患者血清中的表达情况,比较LncRNAHOTAIR、lncBRM、icr与AFP在PLC患者血清表达敏感度与特异度差异,进一步补充和完善血清lncRNAs在原发性肝癌中的早期诊断价值。并借助现代科学技术手段,检测PLC患者血清LncRNAHOTAIR、LncBRM、icr表达水平,将患者的中医辨证分型与检测结果相互对照,以期找出两者的相关性,为临床辨证论治提供依据。方法按照纳入排除标准选取2019年2月至2020年1月期间就诊于我院的PLC病例61例,肝硬化患者20例、健康者20例。参照第9版《中医内科学》和第3版《肿瘤科专病中医临床诊治》,PLC组患者按照中医辨证分型分为:气滞血瘀型、肝郁脾虚型、肝肾阴虚型、湿热内蕴型、湿瘀互结型;并根据2017年版肝癌诊疗规范进行分期,分为Ⅰa期、Ⅰb期、Ⅱa期、Ⅱb期、Ⅲa期、Ⅲb期、Ⅳ期。收集所有入组志愿者废弃血清,采用化学发光酶免疫(CLEIA)法测定AFP值,采用定量反转录聚合酶连锁反应(qRT-PCR)法测定血清 LncRNAHOTAIR、lncBRM、icr 的表达量。结果***患者血清LncRNAHOTAIR、LncBRM、icr表达量显著高于肝硬化组、健康组(P≤0.001),肝硬化组的血清LncRNAs表达高于健康组(P5cm组高于直径≤5cm组(P=0.038,P=0.034)。3.根据血清LncRNAs水平对PLC诊断绘制ROC曲线,LncRNAHOTAIR曲线下面积为0.916,当LncRNA HOTAIR表达水平为0.000082时,其灵敏度为86.9%,特异度为79.5%。LncRNABRM曲线下面积为0.888,当LncRNABRM表达水平为0.000039时,其灵敏度为82%,特异度为79.5%。LncRNAicr曲线下面积为0.92,当LncRNAicr表达水平为0.000294时,其灵敏度为90.2%,特异度为82.1%。AFP的曲线下面积为0.804,其灵敏度为 78.7%,特异度为 82.1%,提示血清 LncRNAHOTAIR、LncBRM、icr表达水平对PLC患者诊断中的价值均高于AFP。***患者中医证型与血清LncRNA HOTAIR、LncBRM、icr表达水平无明显相关性。结论血清LncRNA HOTAIR、LncBRM、icr在PLC患者血清中显著高表达,在肝硬化患者中中度表达,在健康者中不表达或低表达。LncRNAHOTAIR、LncBRM在PLC患者血清中的表达与临床分期、肝外转移、血管侵犯、癌栓形成、肿瘤大小有关,可能参与PLC的发生发展,与中医证型无明显相关性,对临床中医辨证提供依据证据不足。血清LncRNAHOTAIR、LncBRM、icr水平对PLC具有潜在的诊断价值。

关键词：原发性肝癌 LncRNA HOTAIR LncBRM icr AFP 早期诊断中医证型