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Efficacy and Safety of iron Isomaltoside Compared with an Oral iron Supplement in the Management of Patients with iron deficiency Anemia

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Open Journal of Blood Diseases 2024年第1期14卷 17-30页

作者： Zhimin Wu Chunxiao Zhou Chunyan Wu Qiao Song Shilyu Chen Wen Zhang Shaoling Wu Department of Medicine Qingdao University Qingdao China Department of Hematology The Affiliated Hospital of Qingdao University Qingdao China

Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.

关键词： Anemia iron-deficiency Drug Therapy iron Isomaltoside 1000 Treatment Outcome

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Retroperitoneal hyaline-vascular variant Castleman Disease in a patient with iron-deficiency anemia and sinus bradycardia:a case report

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Oncology and Translational Medicine 2017年第4期3卷 176-180页

作者： Chunyang Ma Xingjun Guo Feng Zhu Yuqi Ren Hebin Wang Min Wang Renyi Qin Department of Biliary-Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective Castleman disease, also known as giant lymph node hyperplasia, involves lesions in the lymph nodes usually located in the chest_ENREF_1, particularly in the mediastinum. Meanwhile, sinus bradycardia is a sinus rhythm slower than 60 beats per min, and it can occur in both healthy and sick individuals. However, the comorbidity of these two disorders has not been previously reported. In this paper, we report a case of a 46-year-old woman who presented with persistent sinus bradycardia and irondeficiency anemia. Diagnostic work-up revealed hepatosplenomegaly and a giant mass near the splenic hilum. The mass was removed surgically; after which, the patient's bradycardia resolved immediately, while her anemia was corrected after subsequent chemotherapy. Pathological examination revealed lymph nodes with benign lesions, and the patient was diagnosed with hyaline-vascular variant of Castleman disease. This is the first documented case of sinus bradycardia associated with Castleman disease. In this paper, we describe the case characteristics, discuss the possible pathogenesis, and consider the appropriate treatment of symptomatic sinus bradycardia accompanying Castleman disease.

关键词： Castleman disease sinus bradycardia iron-deficiency anemia

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A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4638-4643页

作者： Fernando Bermejo Santiago García-López Digestive Service University Hospital of Fuenlabrada Fuenlabrada Madrid 28942 Spain Digestive Service University Hospital Miguel Servet Zaragoza 50009 Spain

iron deficiency （ID）, with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by

关键词： Anemia iron-deficiency iron deficiency anemia

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Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin

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World Journal of Gastroenterology 2013年第26期19卷 4166-4171页

作者： Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares Departments of Gastroenterology Hospital Universitari Mútua Terrassa Centro de Investigación Biomédica en Red de Enfer-medades Hepáticas y Digestivas (CIBERehd) Departments of Pathology Hospital Universitari Mútua Terrassa

AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients.

关键词： Helicobacter pylori iron-deficiency anaemia iron refractoriness Gluten-sensitive enteropathy Menopause

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Combating Micronutrient Deficiencies—An Important Component of Poverty Reduction

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Biomedical and Environmental Sciences 2001年第1期14卷 92-97页

作者： MARTIN W. BLOEM REGINA MOENCH-PFANNER LYNNDA KIESS Helen Keller International Regional Office Asia Pacific Helen Keller International Regional Office Asia Pacific Helen Keller International Regional Office Asia Pacific

In the late 1990s, the international development banks and the International Monetary Fund (IMF) convened to outline seven International Development Goals (IDGs) to reduce poverty by 2015. These goals incorporated both the economic and social dimensions of poverty. A two thirds reduction of child mortality and a three fourths reduction of maternal mortality from rates in 1990 by 2015 are two of these seven IDGs. There is a need for better combinations of cost effective strategies to reach these challenging goals by the year 2015. This paper discusses the potential usefulness of micronutrient deficiency control programs for this purpose.

关键词： iron-deficiency PREGNANCY

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Uncovering the uncertainty: Risk factors and clinical relevance of P1 lesions on small bowel capsule endoscopy of anemic patients

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World Journal of Gastroenterology 2016年第38期22卷 8568-8575页

作者： Tiago Cúrdia Gon?alves Mara Barbosa Bruno Rosa Maria Jo?o Moreira José Cotter Gastroenterology Department Hospital da Senhora da Oliveira School of Health Sciences University of Minho ICVS/3B’s PT Government Associate Laboratory

AIM To identify risk factors for P1 lesions on small bowel capsule endoscopy(SBCE) and to describe the natural history of anemic patients with such type of *** One hundred patients were consecutively selected for a case-control analysis performed between 37 cases with P1 lesions and 63 controls with negative SBCE. Age, gender, comorbidities and regular medication were collected. Rebleeding, further investigational studies and death were also analyzed during the *** No significant differences on gender, median age or Charlson index were found between groups. Although no differences were found on the use of proton pump inhibitors, acetylsalicylic acid, anticoagulants or antiplatelet agents, the use of non-steroidal antiinflammatory drugs(NSAID) was associated with a higher risk of P1 lesions(OR = 12.00, 95%CI: 1.38-104.1). From the 87 patients followed at our center, 39 were submitted to additional studies for investigation of iron-deficiency anemia(IDA), and this was significantly more common in those patients with no findings on SBCE(53.7% vs 30.3%, P = 0.033). A total of 29 patients had at least one rebleeding or IDA recurrence episode and 9 patients died of non-anemia related causes but no differences were found between cases and *** P1 lesions are commonly found in patients with IDA submitted to SBCE. The use of NSAID seems to be a risk factor for P1 lesions. The outcomes of patients with P1 lesions do not differ significantly from those with P0 lesions or normal SBCE.

关键词： P1 lesions iron-deficiency anemia Small bowel capsule endoscopy Risk factors Rebleeding

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The Genetic Dissection of a Short-Term Response to Low CO_(2) Supports the Possibility for Peroxide-Mediated Decarboxylation of Photorespiratory Intermediates in the Peroxisome

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Molecular Plant 2012年第6期5卷 1413-1416页

作者： Olivier Keech Wenxu Zhou Ricarda Fenske Catherine Colas-des-Francs-Small John D.Bussell Murray R.Badger Steven M.Smith Centres of Excellence for Plant Metabolomics and Plant Energy Biology University of Western Australia35 Stirling HighwayCrawleyWestern Australia 6009Australia UPSC Department of Plant PhysiologyUmea University90187UmeaSweden Metabolomics Australia University of Western Australia35 Stirling HighwayCrawleyWestern Australia 6009Australia Centre of Excellence in Plant Energy Biology Research School of BiologyAustralian National UniversitySullivans Creek RoadActon ACT 0200Australia

Dear Editor, Photorespiration reduces plant carbon assimilation by an estimated 25%-50% of net CO2 assimilation in typical C3 plants （Roussel and Igamberdiev, 2011）. It results from the oxygenase activity of Rubisco giving rise to phosphogly- colate. Subsequent photorespiratory metabolism involves decarboxylation of glycine in the mitochondrion and reduc- tion of hydroxypyruvate, usually assumed to occur in the peroxisome. Recent research in Arabidopsis has highlighted possible alternative sites of hydroxypyruvate reductase （HPR） activity （Figure 1A）. In addition to the accepted reduction by peroxisomal HPR1, Timm et al. （2008） identified cytosolic HPR2 and a putative chloroplast HPR3 （Timm et al., 2011）. For HPR2 or HPR3 to function in photorespiration, hydroxypyru- vate would first need to pass from the peroxisome into the cytosol. Another potential fate for hydroxypyruvate is its non-enzymic （NE） decarboxylation by reaction with hydrogen peroxide as previously suggested by experiments performed on isolated peroxisomes （Walton and Butt, 1981）.

关键词： HYDROXYPYRUVATE REDUCTASE OXIDATIVE STRESS iron-deficiency ABSENCE CAUSES ARABIDOPSIS CATALASE PLANTS PHOTOSYNTHESIS STOICHIOMETRY METABOLISM

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Relationship between Low iron Stress and iron Efficiency of Soybean Varieties

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Asian Agricultural Research 2017年第12期9卷 37-42页

作者： Minghao ZHANG Zhigang YI Qiang QIU Fangang MENG Demin RAO Jing ZHAO Wei ZHANG Xiaoyan YAN Soybean Research Institute Jilin Academy of Agricultural Sciences/National Engineering Research Center of Soybean Shenyang Agricultural University

We took the iron-efficient and iron-inefficient soybean varieties with significant differences in iron efficiency as the test materials,in order to ascertain the relationship between the low iron stress and the iron efficiency of soybean *** results showed that through the principal component analysis,it was found that the contribution rate of the shoot light energy absorption factor and root morphological factor was the highest,reaching 41.0% and 67.2%,*** to the eigenvector with high absolute value for the two factors,it was found that improving photosynthesis and root surface area could help to improve the ability of soybean to resist low *** the dynamic simulation results of Logistic equation,both V and Vmof the shoot and root of iron-efficient varieties were higher than those of iron-inefficient varieties;the low iron treatment postponed the time of the root of iron-inefficient varieties to reach Vm,while the iron-efficient varieties were resistant to the damage caused by the low iron to growth by improving root ***,when the iron concentration was 0 mM,regardless of iron-efficient varieties or iron-inefficient varieties,the shoot V,Vmand △t were all low,indicating that the division of different iron efficiency varieties was relative,not absolute,and the ability of plant to resist stress was not only determined by its own characteristics,but also closely related to the degree of stress.

关键词： Soybean iron-deficiency iron-efficient iron-inefficient Principal component analysis Logistic model

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