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Warfarin Compliance after Mechanical AVR in the Pediatric Population: Case Series from a Developing Country

World Journal of Cardiovascular Surgery 2022年第8期12卷 184-190页

作者： Suha Zubairi Mohammad Hassan Mirza Mohammad Saad Iqbal Mubashir Zareen Khan Muneer Amanullah Department of Pediatric Cardiac Surgery National Institute of Cardiovascular Diseases Karachi Pakistan

Background and Aim: Mechanical prosthetic heart valves exert a lifelong thromboembolic complication requiring continuous antithrombotic therapy. Vitamin K antagonist is the recommended therapy of choice along with meticulous inr monitoring to achieve and maintain an inr of 2.0 - 3.0. The study aimed to assess the compliance of anticoagulant therapy in pediatric patients after AVR and to highlight the challenges faced during follow-ups. Methods: A retrospective study was conducted at NICVD Hospital in Karachi, Pakistan for a time frame of 2 years from 2020-2021 where 7 patients were selected. Data were collected using hospital medical records and then validated through a phone call mediated structured questionnaire-based interview. Results: 2 out of 7 patients in the case series were compliant to regular follow-ups and had their inr in the desired range owing to their higher education status and access to inr clinic for regular follow-up in urban setting. Younger patients in the case series were non-compliant. 4 out of 7 patients who were on dual anti-coagulant regimens including warfarin and aspirin were either closer or within the range than compared to those on single drug regimen. Conclusion: Compliance was observed in patients who had favorable demographics and higher education. Multiple recent trials including PROACT and PROACT XA are underway to develop novel treatment options apart from warfarin after mechanical aortic valve replacement. Home-based inr testing kits provide easy access to regular testing in remote areas. Multi-center studies are required for in-depth analysis regarding reasons of non-compliance in pediatric population.

关键词： Mechanical AVR Warfarin inr monitoring Anticoagulant Thromboembolic

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