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Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models

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Journal of Oceanology and Limnology 2019年第3期37卷 909-917页

作者： OH Jae-Young RYU Bo-Mi YANG Hye-Won KIM Eun-A LEE Jung-Suck JEON You-Jin Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Jeju International Marine Science Center for Research & Education Korea Institute of Ocean Science and TechnologyJeju 63349Republic of Korea Research Center for Industrial Development of Seafood Gyeongsang National UniversityTongyeong 53064Republic of Korea

Oxidative hair dyes containingρ-phenylenediamine(PPD)are reported to induce an allergic reaction by promoting oxidative stress when absorbed through the skin.Despite the associated risk,these hair dyes remain popular owing to their convenience and sharpness of color.This makes it important to minimize the cytotoxicity and oxidative stress induced by PPD-containing hair dyes.Ecklonia cava extract has been evaluated in different studies for its protective effects against external stress in fibroblasts and keratinocytes.Our study was aimed at using in-vitro and in-vivo models to investigate the extract’s effects on cytotoxicity of and oxidative stress induced by PPD-containing hair dyes.Analysis of CIEL*a*b*Color space was first used to determine the range of E.cava extract that would not interfere with the coloring ability of the dye upon addition.Subsequently,the set ranges of E.cava extract(5% and 7%)were added to the hair dye and their toxicity assessed by evaluating the viability of fibroblasts and keratinocytes.The effects on developmental phenotypes and induction of oxidative stress by hair dye were evaluated and compared with those of hair dyes containing different contents of E.cava extract using an in-vivo zebrafish model.Our results showed that E.cava extract in hair dye could significantly decrease the cytotoxicity and levels of oxidative stress caused by hair dyes containing PPD in both in-vitro and in-vivo models.These results suggest that the addition of 7% E.cava extract to 250μg/mL hair dye does not interfere with the coloring ability of the dye while showing significant protective eff ects against the hair dye.The study proposes that the use of E.cava extract as an adduct to hair dyes containing PPD reduces the cytotoxicity and oxidative stress induced by these hair dyes.

关键词： hair dye Ecklonia cava cytotoxicity oxidative stress in-vitro and in-vivo models

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In vivo hydrogen-1 magnetic resonance spectroscopy study of human intracranial tumors

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Chinese Medical Journal 1998年第1期111卷 56-58页

作者：栾文忠张健 Department of Neurosurgery People's Hospital of Beijing Medical University Beijing 100044 China

ObjectiveTo investigate the metabolic changes, pathological state and histological types of intracranial tumors with hydrogen 1 magnetic resonance spectroscopy (H 1 MRS). Methods Thirteen patients with intracranial tumors were studied with localized proton magnetic resonance spectroscopy (H 1MRS) in vivo. All spectra were obtained with a 2.0 T whole body MR imaging system. Results All the spectra of these tumors exhibited high ratios of choline (Cho) /creatine (Cr) and Cho/N acetyl aspartate (NAA), and histologically different tumors showed obvious variations in the metabolite ratios. Significant differences of Cho/Cr ratio were found between meningiomas and astrocytomas by statistical evaluation. The spectra obtained after operation were remarkably different from those before operation. Conclusion H 1 MRS can serve as a non-invasive clinical test for therapeutic and prognostic uses for intracranial tumors.

关键词： MR SPECTROSCOPY HUMAN GLIOMAS in-vivo INvivo

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One-step method to enhance biotribological properties and biocompatibility of DLC coating by ion beam irradiation

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Friction 2022年第7期10卷 1114-1126页

作者： Yuzhen LIU Kelun ZHANG Jae-Ho HAN Youn-Hoo HWANG Shusheng XU Dae-Eun KIM Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of MedicineSeoul 03722Republic of Korea State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

A one-step method was developed to create a highly biocompatible micropatterned surface on a diamond-like carbon(DLC)through irradiation with a nitrogen ion beam and thus enhance the biocompatibility of osseointegrated surfaces and biotribological performance of articular surfaces.The biocompatibility and biotribological mechanisms were analyzed in terms of the structure and morphology of DLC.It was demonstrated that a layer enriched in sp^(3) C-N bonds was formed on the surface of the DLC after nitrogen ion beam irradiation.Moreover,with an increase in the radiation dose,the content of sp^(3) C-N on the DLC surface increased significantly,and the biocompatibility was positively correlated with it.The adhesion of the MC3T3 osteoblasts increased significantly from 32%to 86%under an irradiation dose of 8×10^(15) ions/cm^(2).In contrast,the micropattern had a significant negative effect on the adhesion of the osteoblasts as it physically hindered cell expansion and extension.The micropattern with a depth of 37 nm exhibited good friction properties,and the coefficient of friction was reduced by 21%at relatively high speeds.

关键词： ion beam irradiation biocompatibility diamond-like carbon(DLC) in-vivo micropattern biotribological performance

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A review of effective strides in amelioration of the biocompatibility of PEO coatings on Mg alloys

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Journal of Magnesium and Alloys 2022年第9期10卷 2354-2383页

作者： Arash Fattah-alhosseini Razieh Chaharmahali Kazem Babaei Meisam Nouri Mohsen K.Keshavarz Mosab Kaseem Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooON N2L 3G1Canada Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Recently,developing bioactive and biocompatible materials based on Mg and Mg-alloys for implant applications has drawn attention among researchers owing to their suitable body degradability.Implementing Mg and its alloys reduces the risk of long-term incompatibility with tissues because of their close mechanical properties and no need for re-operation to remove the implant.Nevertheless,the degradation rate of the implant needs to be controlled because production of hydrogen gas and accumulation of its bubbles increases local pH around the implants.To confine the integrity of implants and the body,the corrosion concern in the body fluid requires to be addressed.Surface modification as one of the effective strategies can improve corrosion resistance.Besides,it creates a suitable surface for bone grafting and cell growth.The development of proper surface-coated implants needs appropriate techniques and approaches.Plasma electrolytic oxidation(PEO)coating can provide long-term protection by providing a ceramic layer and improving the implant’s biocompatibility.Herein,a general review of in-vivo and in-vitro evaluation of PEO coatings on Mg and Mg-alloys has been carried out.Recent advances in surface modification on Mg and Mg-alloys have been discussed,however,the need for reliable laboratory models to predict in-vivo degradation is still valid.

关键词： Mg alloys Biodegradation Surface modification in-vivo In-vitro PEO coatings

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Biomimetic Hydroxyapatite Coated Titanium Screws Demonstrate Rapid Implant Stabilization and Safe Removal in-vivo

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 20-35页

作者： Jan Henrik Sorensen Lutz Durselen Ken Welch Torben Christian Sorensen Philip Procter Hakan Engqvist Maria Stromme Anita Ignatius Hartwig Steckel Department of Pharmaceutics and Biopharmaceutics Christian-Albrechts UniversityKielGermany Institute of Orthopaedic Research and Biomechanics Centre of Musculoskeletal ResearchUlmGermany Division for Nanotechnology and Functional Materials The Angstrom LaboratoryUppsala UniversityUppsalaSweden Stryker Trauma GmbH SchonkirchenGermany Stryker Trauma AG SelzachSwitzerland Division for Applied Materials Sciences The Angstrom LaboratoryUppsala UniversityUppsalaSweden

The early fixation of bone screws after surgical implantation still remains a challenge in the field of traumatology. Whilst hydroxyapatite (HA) coatings are known to enhance the fixation of implants;their removal at a later time-point may be problematic. An HA coating has been developed to demonstrate that both implant fixation and safe removal are feasible in the same design. Accordingly the aim of this study was to compare the in-vivo performance of thin biomimetic HA coated titanium screws to uncoated counterparts used as control after bilateral implantation in the femoral condyle of 36 New Zealand White Rabbits. The screws were analysed macroscopically, by histology, micro-CT and biomechanically at both two and six weeks post-implantation. The HA coated screws demonstrated excellent biocompatibility. At two weeks the HA coated screws demonstrated a significant increase in removal torque values as well as a strong trend towards higher pull-out forces. In addition histology confirmed a higher degree of osseointegration and direct bone to implant contact. At six weeks no difference in pull-out force and removal torque could be detected. SEM images confirmed the absence of any residual HA coating indicating a fast coating degradation in-vivo. The low level of removal torque after full osseointegration at 6 weeks supports the feasibility of safe and easy removal of the implant. The HA coating under study appears to offer a unique characteristic of enhanced fixation with a minimal increase in removal torque after full osseointegration. This may be of value in clinical applications where it is necessary to assure both screw fixation and later removal.

关键词： Biomimetic Hydroxyapatite in-vivo Screw Implant Removal Pull-Out Force Removal Torque

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Mathematical Modelling of in-vivo Dynamics of HIV Subject to the Influence of the CD8+ T-Cells

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Applied Mathematics 2017年第8期8卷 1153-1179页

作者： Purity M. Ngina Rachel Waema Mbogo Livingstone S. Luboobi Strathmore Institute of Mathematical Sciences Strathmore University Nairobi Kenya

There have been many mathematical models aimed at analysing the in-vivo dynamics of HIV. However, in most cases the attention has been on the interaction between the HIV virions and the CD4+ T-cells. This paper brings in the intervention of the CD8+ T-cells in seeking, destroying, and killing the infected CD4+ T-cells during early stages of infection. The paper presents and analyses a five-component in-vivo model and applies the results in investigating the in-vivo dynamics of HIV in presence of the CD8+ T-cells. We prove the positivity and the boundedness of the model solutions. In addition, we show that the solutions are biologically meaningful. Both the endemic and virions- free equilibria are determined and their stability investigated. In addition, the basic reproductive number is derived by the next generation matrix method. We prove that the virions-free equilibrium state is locally asymptotically stable if and only if R0 < 1 and unstable otherwise. The results show that at acute infection the CD8+ T-cells play a paramount role in reducing HIV viral replication. We also observe that the model exhibits backward and trans-critical bifurcation for some set of parameters for R0 . This is a clear indication that having R0 is not sufficient condition for virions depletion.

关键词： HIV Endemic Equilibrium Global Stability in-vivo Disease-Free Equilibrium Basic Reproductive Number Backward Bifurcation

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<i>in-vivo</i>Dosimetry Method for Measuring Peak Surface Dose Using Radiochromic Films during Computed Tomography Scanning of the Sinus

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2018年第2期7卷 151-159页

作者： Khaled Soliman Salman Altimyat Abdullah Alrushoud Ahmed Alenezi Mohammed Alkhorayef Medical Physics Department Prince Sultan Military Medical City Riyadh KSA Department of Radiological Sciences College of Applied Medical Sciences King Saud University Riyadh KSA

Purpose: During computed tomography (CT) helical scanning mode the patient surface dose distribution is assumed to be non-uniform, therefore point dose measurement methods may lead to imprecise estimation of the radiation dose received by the patient skin in particular. We have used XRQA2 films as in-vivo dosimeters to measure the entrance skin dose during sinus exams. Methods: The films were placed under the patient head rest in order to sample the entrance surface dose in-vivo. We have performed in-vivo film irradiation on 23 patients in this study to verify the clinical suitability of the method and were found adequate. Results: The measured average ESD in the sinus exam was 11.7 ± 1.0 mGy, the PSD was 15.7 ± 1.7 mGy and the CTDI(vol) was 13.3 ± 0.1 mGy. The ratio of ESD/CTDI(vol) and PSD/CTDI(vol) was 0.88 and 1.18 respectively. The results indicate that the scanner registered CTDI(vol) underestimates the PSD and in the same time it overestimates the ESD by 18% and 13.6% respectively. Conclusion: The observed differences between the ESD, PSD and CTDI(vol) although seem small for the radiation dose range measured during CT of the sinus [13.2 - 13.4] mGy, but important for the medical physicist to know, since monitoring of patients’ doses from CT examinations is becoming more mandatory. The use of radiochromic film as in-vivo dosimeter does not interfere with the clinical radiological exam and does not produce any image artifacts. The method can be used to study other CT examinations specially the ones with large beam width, high pitch factor and high dose exams. The method allows measurement of the peak skin dose, examination of the CT dose profile and the 2D dose distribution in the XZ plan.

关键词： Radiochromic Films Sinus CT in-vivo Dosimetry CTDI(Vol) Entrance Surface Dose

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Production of porous Ni-Ti alloy and test of its biocompatibility under in-vivo conditions

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Journal of Biomedical Science and Engineering 2010年第12期3卷 1161-1168页

作者： Ali Kaya Gur Nuri Orhan Emine Unsaldi Ali Said Durmus Neriman Colakoglu Department of Metallurgy Education Technical Education FacultyFirat UniversityElazigTurkey Department of Surgery Faculty of VeterinaryFirat UniversityElazigTurkey Histology and Embryology Department Medical FacultyFirat UniversityElazigTurkey

Biomaterials have been out of commonly used materials in biomedical applications in recent years. Today among the mostly-used biocompatible metals are especially Ni-Ti alloys. For conducting this study, having extensive usage area in biomedical applications, Ni and Ti materials were utilized for an alloy production. Following being mixed using a suitable mixer at 49Ni/51Ti %wt., the alloy was exposed to cold pressure of 200 MPa and sintered in a mold. In addition, the material gained porosity appearance thanks to usage of the synthesized (SHS) method and then the final shape of the specimen was taken using the method of wire electro erosion discharge machining (WEDM). Afterwards, the specimen was subjected to the biocompatibility test in in-vivo environment by means of on a 3-year-old female dog.

关键词： Biomaterials NiTi Igntion Implant in-vivo

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Position Verification of the RADPOS 4-D <i>in-vivo</i>Dosimetry System

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第4期4卷 318-325页

作者： Ryosuke Kohno Hidenori Yamaguchi Kana Motegi Fumiya Tanaka Tsunemichi Akita Yuki Nagata Kenji Hotta Tomoko Miyagishi Shie Nishioka Takeshi Dohmae Tetsuo Akimoto Particle Therapy Division National Cancer Center Hospital East Kashiwa Japan Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba Japan

The accuracy of the position measurements obtained by the radiation positioning system (RADPOS) was evaluated under static and dynamic conditions. In the static verifications, the RADPOS was fixed to the treatment couch in a photon treatment room and a proton treatment room, and was translocated with the treatment couch in x, y and z directions. Because the presence of magnetic and/or electrically conductive materials can cause a systematic shift in the measured position by distorting the RADPOS transmitted field, the effect of metals on the performance of the positioning system was also investigated. Dynamic verification was performed using the couch drive and a dynamic anthropomorphic thorax phantom. We thus confirmed the utility of RADPOS as a position sensor to perform in vivo dosimetry.

关键词： RADPOS MOSFET in-vivo Dosimetry Position Sensor Photon Therapy Proton Beam Therapy

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A Consensus Modeling Approach for the Determination of Stratum Corneum Thickness Using in-vivo Confocal Raman Spectroscopy

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第4期2卷 241-251页

作者： Thomas M. Hancewicz Chunhong Xiao Jesse Weissman Vickie Foy Shuliang Zhang Manoj Misra Advanced Measurement and Data Modeling Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA.

The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function;2) frequency of minimum model error for consensus vs. individual SC thickness values;and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).

关键词： in-vivo Raman Spectroscopy Confocal Raman Spectroscopy Reflectance Confocal Microscopy Stratum Corneum Thickness

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