Cytokine storms are crucial in the development of various inflammatory diseases,including sepsis and autoimmune *** immunosuppressive cytokine INTERLEUKIN(il)-37 consists of five isoforms(il-37a-e).We identified il-37...
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Cytokine storms are crucial in the development of various inflammatory diseases,including sepsis and autoimmune *** immunosuppressive cytokine INTERLEUKIN(il)-37 consists of five isoforms(il-37a-e).We identified il-37a as a nuclear cytokine for the first *** to il-37b,il-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic *** full-length(FL)form of il-37a and the N-terminal fragment,which is processed by elastase,could translocate into cell nuclei through a distinctive nuclear localization sequence(NLS)/importin nuclear transport *** forms exerted their regulatory effects independent of the il-1R8 receptor by transcriptionally upregulating the nuclear receptor peroxisome proliferator-activated receptor(PPARγ).This process involved the recruitment of the H3K4 methyltransferase complex WDR5/MLL4/C/EBPβand H3K4me1/2 to the enhancer/promoter of *** receptor-independent regulatory pathway of the nuclear il-37a–PPARγaxis and receptor-dependent signaling by secreted il-37a maintain homeostasis and are potential therapeutic targets for various inflammatory diseases,including sepsis.
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