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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 59-60页

作者： Ishizu T. Osoegawa M. J.-I. Kira 夏峰 Department of Neurology Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashiku Fukuoka 812-8582 Japan Prof.

There are two distinct subtypes of multiple sclerosis in Asians, opticospinal (OS- multiple sclerosis) and conventional (C- multipie sclerosis). In OS- mu ltiple sclerosis, selective and severe involvement of the optic nerves and spina l cord is characteristic, though its mechanisms are unknown. The present study a imed to find out possible differences in the cytokine/chemokine profiles in CSF between OS- multiple sclerosis and C- multiple sclerosis and to delineate the relationships between these profiles and neuroimaging and pathological features. Sixteen cytokines/chemokines, namely interieukin (il)- 1β , il- 2, il- 4, I L- 5, il- 6, il- 7, il- 8, il- 10, il- 12 (p70), il- 13, il- 17, interfe ron (IFN)- γ , tumour necrosis factor (TNF)- α , granulocyte colony- stimul ating factor (G- CSF), monocyte chenioattractant protein- 1 (MCP- 1) and macr ophage inflammatory protein- 1β (MIP- 1β ), were measured simultaneously in CSF supernatants from 40 patients with relapsing- remitting multiple sclerosis (20 OS- multiple sclerosis and 20 C- multiple sclerosis) at relapse and 19 con trol patients with spinocerebellar degeneration (SCD), together with intracellul ar production of IFN- γ and il- 4 in CSF CD4+ T cells. In CSF supernatants relative to controls, il- 17, MIP- 1β ,il- 1β and il- 13 were only signi ficantly increased in OS- multiple sclerosis patients, while TNF- α was only significantly increased in C- multiple sclerosis patients, using a cut- off l evel of 1 pg/ml. il- 8 was significantly elevated in both OS- multiple scleros is and C- multiple sclerosis patients. MCP- 1 was significantly decreased in b oth OS- multiple sclerosis and C- multiple sclerosis patients, while il- 7 wa s only significantly decreased in C- multiple sclerosis patients. il- 17, il- 8 and il- 5 were significantly higher in OSmultiple sclerosis patients than in C- multiple sclerosis patients. The increases in il- 17 and il- 8 in OS mult iple sclerosis were still significant even after excl

关键词：多发性硬化症 il-17/il-8 髓鞘粒细胞浸润肿瘤坏死因子趋化因子集落刺激因子免疫调节治疗髓过氧化物酶嗜中性

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