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High-dose radiation associated with improved survival in IDH-wildtype lowgrade glioma

Chinese Neurosurgical Journal 2021年第2期7卷 126-130页

作者： Shuai Liu Yanwei Liu Guanzhang Li Jin Feng Li Chen Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China

Background:As molecular advances have deepened the knowledge on low-grade glioma(LGG),we investigated the effect of higher radiation dose on the survival of IDH-wildtype(idhwt)LGG.Methods:In the current study,52 idhwt LGG patients who received radiotherapy were enrolled from the Chinese Glioma Genome Atlas dataset.Radiation doses>54 Gy were defined as high-dose,whereas doses≤54 Gy were defined as low-dose.We performed univariate and multivariate survival analyses to examine the prognostic role of high-dose radiotherapy.Results:In total,the radiation dose ranged from 48.6 Gy to 61.2 Gy,with a median of 55.8 Gy,and 31 patients were grouped into high-dose radiation.Univariate survival analysis indicated that high-dose radiotherapy(p=0.015),tumors located in the frontal lobe(p=0.009),and pathology of astrocytoma(p=0.037)were significantly prognostic factors for overall survival.In multivariate survival analysis,high-dose radiotherapy(p=0.028)and tumors located in the frontal lobe(p=0.016)were independently associated with better overall survival.Conclusions:In conclusion,high-dose radiotherapy independently improved the survival of idhwt LGG.This can guide treatments for glioma with known molecular characteristics.

关键词： Radiation dose IDH-wildtype Low-grade glioma Survival

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