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大鼠脑区金属元素空间分布的激光剥蚀-电感耦合等离子体质谱(LA-icp-ms)分析

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中国无机分析化学 2025年

作者：师程程刘曼雪程琳耿柠波于颖张海军陈吉平大连海事大学环境科学与工程学院中国科学院大连化学物理研究所大连交通大学交通工程学院环境科学与工程系

金属元素的脑区分布对于理解大脑的生理功能、疾病的发生机制以及开发新的治疗策略都具有重要的意义。利用电感耦合等离子体质谱(icp-ms)和激光剥蚀-电感耦合等离子体质谱(LA-icp-ms)对大鼠脑中的金属元素进行定量和原位成像分析，元素... 详细信息

金属元素的脑区分布对于理解大脑的生理功能、疾病的发生机制以及开发新的治疗策略都具有重要的意义。利用电感耦合等离子体质谱(icp-ms)和激光剥蚀-电感耦合等离子体质谱(LA-icp-ms)对大鼠脑中的金属元素进行定量和原位成像分析，元素定量分析结果进行脑区分布特征研究、统计分析和相关性分析。结果表明，大鼠脑中金属元素的含量和分布存在显著差异，这可能与不同脑区的生理功能和代谢活动有关，其中镁、锌元素是脑中含量较丰富的元素，主要分布在胼胝体、尾壳核、侧隔核、纤维边缘以及侧嗅束部分，而铜主要分布在侧隔核、纤维边缘、第三脑室区域。痕量金属铬和镍主要分布在胼胝体。LA-icp-ms可以对体内元素的空间分布进行原位成像，可以用于研究金属元素在神经系统疾病中的作用，揭示潜在的健康风险。

关键词： icp-ms LA-icp-ms 原位成像元素分析空间分布

超声辅助提取结合icp-ms测定工作场所空气中25种金属元素的方法研究及应用

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预防医学情报杂志 2025年

作者：甘鹏李龙杰重庆市沙坪坝区疾病预防控制中心

目的建立超声辅助提取-icp-ms法测定工作场所空气中25种金属元素的方法，并将其应用于实际场所检测。方法使用Minitab 21软件进行混料实验设计和中心复合实验设计，应用满意度函数处理多响应变量，建立多元二次回归方程确定最优前处... 详细信息

目的建立超声辅助提取-icp-ms法测定工作场所空气中25种金属元素的方法，并将其应用于实际场所检测。方法使用Minitab 21软件进行混料实验设计和中心复合实验设计，应用满意度函数处理多响应变量，建立多元二次回归方程确定最优前处理条件，并对其进行方法学评价。同时将采集焊接作业场所空气的微孔滤膜分别经超声辅助提取与国家标准前处理方法（电热板消解法）处理后，经icp-ms检测其中25种金属元素，所得数据采用SPSS 25.0软件进行配对t检验，检验水准为α=0.05。结果确定最佳前处理条件为0.5 ml硝酸、70℃超声温度和8 min超声时间，25种元素的线性相关系数（r）均大于0.999，检出限为0.01～4.50μg/L，最低检出浓度为1.2×10-6～8.9×10-4mg/m3（以采集75L空气样品计），加标回收率在95.4%～105.0%，日内精密度和日间精密度分别为0.6%～3.6%和2.3%～9.5%，消解效率均大于95%，样品在常温下可至少保存14 d。比较超声辅助提取和国家标准前处理方法，结果无统计学差异（P均<0.05），且对滤膜质量控制样品测定结果符合参考值要求。结论该方法经济环保、高效快速、灵敏准确，为快速评估职业健康环境提供有效技术支持。

关键词：超声辅助提取金属元素工作场所空气 icp-ms

Bioeffects of Rare Earth Complex on Rats Studied by NMR and icp-ms Spectroscopy

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Journal of Rare Earths 2005年第2期23卷 245-250页

作者：吴惠丰李晓晶廖沛球吴亦洁裴奉奎聂毓秀 Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022China College of Basic Medicine Science Jilin University Changchun 130021 China

The bioeffects of Changle, a rare earth complex on rats were investigated using NMR and icp techniques. Wistar rats were administrated orally with Changle (a rare earth-containing fertilizer additive applied in agriculture to raise the production of crops) at doses of 2, 5 and 20 mg·kg^(-1) body weight/day respectively for 90 d. The urine of Changle-treated rats was collected at 45 and 90 d and serum samples were taken after 90 d. The relative concentrations of some important endogenous metabolites in biofluids were determined by ()~1H NMR spectra and the contents of the four rare earth elements (La, Ce, Pr and Nd) constituting Changle in the serum samples were measured by icp-ms technique. Changle-induced renal and liver damage is demonstrated based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethylglycine, dimethylamine, succinate, α-Ketoglutarate ethanol and the alteration of rare earth concentrations in serum.

关键词： biofluids Changle NMR icp-ms metabolism rare earths

Comparison of Biochemical Effects Induced by Changle between Male and Female Rats Using NMR and icp-ms Techniques

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Journal of Rare Earths 2006年第1期24卷 108-114页

作者：吴惠丰李晓晶冯江华李伟生李中峰廖沛球吴亦洁裴奉奎 Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Metabolic profiles caused by rare earth complex were investigated using NMR and icp-ms techniques. Male and female Wistar rats were treated orally with Changle （A kind of rare earth complex applied in agriculture to raise the production of crops） at dose of 2, 5 and 20 mg·kg^-1 body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from ^1H NMR spectra and the contents of the four rare earth elements （La, Ce, Pr and Nd） constituting Changle in the serum samples are measured by icp-ms technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, α- ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum.

关键词： biofluid Changle NMR icp-ms metabolism rare earths

Determination of trace and rare-earth elements in Chinese soil and clay reference materials by icp-ms

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Chinese Journal Of Geochemistry 2014年第1期33卷 95-102页

作者： LIU Ye DIWU Chunrong ZHAO Yan LIU Xiaoming YUAN Honglin WANG Jianqi State Key Laboratory of Continental Dynamics Department of GeologyNorthwest University

Inductively coupled plasma mass spectrometry(icp-ms) has become a powerful tool for providing reliable analytical results in many laboratories around the word. In this study, the mixture of HF and HNO3 acids in high-temperature and high-pressure closed-vessel digestion technique were used to decompose some Chinese reference materials, and thirty seven elements were determined by icp-ms. Most of the results for Chinese soil reference materials were found to be in reasonable agreement with the reference values, except Cs, Ta, Li, Ge, Zn, Nd, Tb and Ta whose values need to be revised. Their precisions were typically lower than 5% RSD. However, the Precisions of Chinese clay reference materials, especially for GBW03102 and GBW03102a, were significantly different with reference values, probably reflecting the existence of a coarser-grained fraction(>70 μm) in samples, and the formation of fluorides in Al-rich samples during sample decomposition by using the mixture of HF and HNO3 acids. Moreover, thirty-seven trace elements covering the mass range from Li to U in four Chinese clay reference materials were firstly provided with good precision and accuracy in this study.

关键词： icp-ms 中国土壤参考资料稀土元素粘土测定电感耦合等离子体质谱样品分解

Determination of Fe,Ni,Cu,Zn,Cd and Pb in seawater by isotope dilution automatic solid-phase extraction—icp-ms

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Acta Oceanologica Sinica 2022年第8期41卷 129-136页

作者： Yuncong Ge Ruifeng Zhang Ziyuan Jiang Zhan Shen Maojun Yan School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratory for Polar Science of Ministry of Natural Resources Polar Research Institute of ChinaShanghai 200136China

A thorough understanding of the biogeochemical cycling of trace metals in the ocean is crucial because of the important role these elements play in regulating metabolism in marine biotas and thus,the ***,a precise and accurate analysis of trace metals in seawater is difficult because they are present at extremely low concentrations in a high salt *** this study,we report an analytical method for the preconcentration and separation of six trace metals,Fe,Ni,Cu,Zn,Cd and Pb,in seawater using a sea FAST automatic solid-phase extraction device,analysis by a triple quadrupole collision/reaction technique with inductively coupled plasma mass spectrometry(icp-ms),and quantification by the isotope dilution technique.A small volume(10 m L)of seawater sample was mixed with a multi-element isotope spike and subjected to sea FAST *** preconcentrate solution was then analyzed using the optimized collision/reaction cell mode of icp-ms,with NH_(3)gas for Fe and Cd with a flow rate of 0.22 m L/min and He for Ni,Cu,Zn and Pb with a flow rate of 4.0 m L/*** procedure blanks were 130 pmol/L,3.0 pmol/L,6.8 pmol/L,37 pmol/L,0.29 pmol/L and 0.42 pmol/L,for Fe,Ni,Cu,Zn,Cd and Pb,*** method was validated using five reference materials(SLRs-6,SLEW-3,CASS-6,NASS-7 and GEOTRACE-GSC),and our results were consistent with the consensus *** method was further validated by measuring full-water-column seawater samples from the subtropical Northwest Pacific Ocean,and our results demonstrated good oceanic consistency.

关键词： seaFAST trace metals isotope dilution seawater icp-ms

A preliminary study of isopropyl alcohol matrix effect and correction in icp-ms

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Chinese Chemical Letters 2007年第10期18卷 1297-1300页

作者： Zhao Chu Hu Shan Gao Sheng Hong Hu Yong Sheng Liu Hai Hong Chen State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China ＇State Key Laboratory of Continental Dynamics Northwest University Xi＇an 710069 China

Isopropyl alcohol matrix effect was found to be element specific by using the defined matrix effect factor in icp-ms, which could not be corrected by using the conventional internal reference method. Unlike the conventional internal reference method, the presented method allows for the analyte to behave differently from the internal reference under the influence of the matrix.

关键词： icp-ms Isopropyl alcohol Matrix effect

A modular single-cell pipette microfluidic chip coupling to ETAAS and icp-ms for single cell analysis

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Chinese Chemical Letters 2022年第3期33卷 1373-1376页

作者： Xing Wei Meng Yang Ze Jiang Jinhui Liu Xuan Zhang Mingli Chen Jianhua Wang Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityShenyang 110819China

Accurate single-cell capture is a crucial step for single cell biological and chemical analysis. Conventional single-cell capturing often confront operational complexity, limited efficiency, cell damage, large scale but low accuracy, incompetence in the acquirement of nano-upgraded single-cell liquid. Flow cytometry has been widely used in large-scale single-cell detection, while precise single-cell isolation relies on both a precision operating platform and a microscope, which is not only extremely inefficient, but also not conducive to couple with modern analytical instruments. Herein, we develop a modular single-cell pipette(m SCP) microfluidic chip with high efficiency and strong applicability for accurate direct capture of single viable cell from cell suspensions into nanoliter droplets(30-1000 n L). The m SCP is used as a sampling platform for the detection of Cd Te quantum dots in single cells with electrothermal atomic absorption spectrometry(ETAAS) for the first time. It also ensures precise single-cell sampling and detection by inductively coupled plasma mass spectrometry(icp-ms).

关键词： Single-cell pipette Microfluidic chip Single-cell capture ETAAS icp-ms CdTe QDs

Application of chemical vapor generation in icp-ms:A review

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Chinese Science Bulletin 2013年第18期58卷 1980-1991页

作者： GAO Ying LIU Rui YANG Lu Chengdu University of Technology Chemical Metrology National Research Council Canada

Chemical vapor generation(CVG) is an important sample introduction technique,and is widely used for atomic spectrometry for its enhanced sensitivity and *** the past 30 years,inductively coupled plasma mass spectrometry(icp-ms) has become a widely used and the most sensitive instrument for(ultra-)trace element determination and elemental speciation.A review of applications of this state-of-the-art coupling of CVG and icp-ms is *** is focused on its applications for both element determination and speciation,including hydride generation,cold vapor generation,photochemical vapor generation,alkylation,and electrochemical vapor *** addition,recent studies undertaken isotope dilution calibration in CVG-icpms for achieving improved accuracy and precision are summarized,and the future perspectives are discussed.

关键词： icp-ms 冷蒸气发生化学气相应用程序电感耦合等离子体质谱仪微量元素测定元素形态原子光谱法