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Association between intestinal microbiota and inflammatory bowel disease

Animal models and Experimental Medicine 2022年第4期5卷 311-322页

作者： Yunchang Zhang Xuemeng Si Ling Yang Hui Wang Ye Sun Ning Liu Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijingChina State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijingChina Beijing Advanced Innovation Center for Food Nutrition and Human Health Department of Nutrition and HealthChina Agricultural UniversityBeijingChina Department of Food and Bioengineering Beijing Vocational College of AgricultureBeijingChina Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBeijingChina

Inflammatory bowel disease(ibd),which includes Crohn’s disease(CD)and ulcerative colitis(UC),has emerged as a global disease with high incidence,long duration,devastating clinical symptoms,and low curability(relapsing immune response and barrier function defects).Mounting studies have been performed to investigate its pathogenesis to provide an ever-expanding arsenal of therapeutic options,while the precise etiology of ibd is not completely understood yet.Recent advances in highthroughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and ibd.In general,dysbiosis characterized by an imbalanced microbiota has been widely recognized as a pathology of ibd.However,intestinal microbiota alterations represent the cause or result of ibd process remains unclear.Therefore,more evidences are needed to identify the precise role of intestinal microbiota in the pathogenesis of ibd.Herein,this review aims to outline the current knowledge of commonly used,chemically induced,and infectious mouse models,gut microbiota alteration and how it contributes to ibd,and dysregulated metabolite production links to ibd pathogenesis.

关键词： dysbiosis ibd model intestinal microbiota metabolites

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