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Biodegradable magnesium alloy as a new connecting material for iodine-125 brachytherapy:an initial experimental study in a rabbit VX2 model

Biodegradable magnesium alloy as a new connecting material f...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Dong Chen1,Guang-feng Duan1,Yan-ling Zhang2,Sheng Peng1 Jian-jun Han1,Chuan-xing Li 1*,Fu-jun Zhang 1* 1.Department of imaging and interventional Radiology,Cancer Center of Sun Yat-sen University,Guangzhou,510060,People’s Republic of China 2.School of Biotechnology,Southern Medical University,Guangzhou 510515,People’s Republic of China

Objective To evaluate the in vivo degradation characteristics and tissue compatibility of new i125 seed chains connected with the biodegradable magnesium alloy AZ31 in New Zealand rabbits. Methods Thirty New Zealand rabbits were randomly divided into three *** group A,magnesium alloy radioactive i125 seeds chains were implanted into VX2 tumors;in group B,magnesium alloy non-radioactive i125 seeds chains were implanted into normal muscle;group C served as an untreated control *** mass loss of the AZ31 magnesium alloy connecting material was measured in the two groups at different time points after implantation of the i125 seed *** and histological changes at the implantation site and in organs were monitored using light microscopy,and seed displacement was assessed using regular X-ray and computed tomography(CT) *** and urine samples were collected from all experimental animals to measure changes in magnesium ion concentrations. Results The new 1125 seed chains made with AZ31 magnesium alloy began to degrade during the first week after *** day 21,the degradation rate was 81%in muscle tissue and 83%in tumor tissue;these degradation rates are not statistically *** after implantation,a mild local inflammatory response and gas production were induced;the gas disappeared 21 days after *** magnesium ion concentrations after implantation were relatively stable,but urine magnesium concentrations increased and fluctuated over a larger *** inspection of the liver,kidney,heart,and spleen of all animals implanted with 1125 seed chains revealed no significant *** 7 days after the implantation of magnesium alloy radioactive 1125 seed chains into tumors,the connecting material showed good connecting and fixing *** 21 days after implantation,the seeds had separated from each other,displacement had occurred,and the radioactive seeds had aggregated in concordance with

关键词： i125 radioactive stranded seeds biodegradable magnesium alloy VX2 tumor biocompatibility

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