检索结果-南通市图书馆

Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development

World Journal of Gastroenterology 2010年第11期16卷 1304-1313页

作者： H Joe Wang Samir Zakhari M Katherine Jung Division of Metabolism and Health Effects National Institute on Alcohol Abuse and Alcoholism National Institutes of Health

Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention.

关键词： Chronic alcohol use Chronic inflammation Li- popolysaccharides Pro-inflammatory and anti-inflammatory cytokines Kupffer cells Monocytes Tumor necrosis factor α Interleukin-10 Neuroendocrine hypothalamo-pituitary-adrenal axis Glucocorticoid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diagnosis and management of pediatric adrenal insufficiency

引用

World Journal of Pediatrics 2016年第3期12卷 261-274页

作者： Ahmet Ucar Firdevs Bas Nurcin Saka Growth-Development and Pediatric Endocrine Unit Istanbul School of MedicineIstanbul UniversityTurkey

Background:adrenal insufficiency(AI)is a wellknown cause of potentially life-threatening *** at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function,leading to varying degrees of glucocorticoid(GC)*** AI induced by exogenous GCs is the most common cause of *** criteria for the diagnosis and management of iatrogenic AI,neonatal AI,and critical illness-related corticosteroid insuffi ciency(CIRCI)are not *** sources:We reviewed the recent original publications and classical data from the literature,as well as the clinical,diagnostic and management strategies of pediatric ***:Practical points in the diagnosis and management of AI with an emphasis on iatrogenic AI,neonatal AI,and CIRCI are *** the lack of sensitive and practical biochemical tests for diagnosis of subtle AI,GC treatment has to be tailored to highly suggestive clinical symptoms and *** of adrenal crisis is well standardized and patients almost invariably respond well to *** is mainly the delay in treatment that is responsible for mortality in adrenal ***:Education of patients and health care professionals is mandatory for timely interventions for patients with adrenal crisis.

关键词： adrenal insuffi ciency critical illness hypothalamo-pituitary-adrenal axis iatrogenic steroids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress

引用

Neuroscience Bulletin 2010年第4期26卷 297-303页

作者：王姗姗闫雪波 Michel A.Hofman Dick F.Swaab 周江宁解放军总医院南楼神经内科北京100853 合肥微尺度物质科学国家实验室中国科学技术大学生命科学院神经生物学系合肥230027 荷兰皇家艺术与科学研究院神经科学研究所

Objective Corticotropin-releasing hormone（CRH）plays an important role in neuroendocrine,autonomic and behavioral responses to *** the present study,the effect of chronic unpredictable mild stress（CUMS）on CRH neurons was investigated in rat *** The rats were exposed to one of the stressors each day for 21 *** was performed to detect the CRH-positive neurons in the paraventricular nucleus（PVN）of the hypothalamus and in *** After the stress protocol,the animals showed a reduction in body weight gain as well as reduced sucrose preference and locomotor ***,the CRH neurons in both PVN and central nucleus of the amygdala（CeA）were stimulated by *** densities of CRH-containing neurons in both PVN and CeA were significantly higher than those in control *** The CRH systems in PVN and CeA may both contribute to depression-like behaviors during CUMS.

关键词： chronic unpredictable mild stress hypothalamo-pituitary-adrenal axis corticotropin-releasing hormone amygdala paraventricular nucleus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effect of intraperitoneal pentobarbital injection on the male rat stress response

The effect of intraperitoneal pentobarbital injection on the...

引用

中国神经科学学会第十届全国学术会议

作者： Xue-Yan WU Xin-Zhong CHEN Jing LU Zhao-Pin WANG Li-Gen SHI Qiong-Bin ZHU Juan-Li WU Ai-Min BAO Department of Neurobiology Department of Anesthesia Women's HospitalZhejiang University School of Medicine

Background Anesthetics such as pentobarbital are generally applied before sacrificing animals,but their effect on stress responses has not been *** present study aimed at revealing the effect of intraperitoneal（ip）pentobarbital injection on the stress responses in rat before *** 69 Sprague Dawley male rats were randomly divided into 7 groups:chronic unpredictable stresses（CUS） rats sacrificed with direct decapitation（CUSD,n=10）,CUS rats sacrificed following ip injection of pentobarbital before decapitation（CUSP,n=10）,acute electric foot shock（FS） rats sacrificed with direct decapitation（FSD,n=10）;FS rats sacrificed following ip injection of pentobarbital before decapitation（FSP,n=10）,control rats sacrificed with direct decapitation（CTRD,n=10）,control rats sacrificed following ip injection of pentobarbital before decapitation（CTRP,n=10）,and control rats sacrificed with ip injection of saline before decapitation（CTRS,n=9）.Plasma concentrations of corticosterone（CORT）,testosterone（T）and estradiol（E2） and hypomalamic mRNA levels of corticotrophin-releasing hormone（CRH）,vasopressin（AVP） and oxytocin（OXT）,all of which are stress-related molecules,were *** CUSD and FSD groups both showed significantly increased plasma CORT,T and E2 levels compared with the CTRD group（P ＜ 0.01） while these significant changes disappeared in CUSP or FSP rats compared with the CTRP *** the hypothalamus,differences between CUSD or FSD group and the CTRD group in the CRH-,AVP- or OXT-mRNA expression did not change significantly following ip injection of pentobarbital before *** addition,ip injection of saline showed similar effects as ip injection of *** ip injection of pentobarbital before decapitation may significantly affect the chronic or acute stress responses,especially for plasma parameters,which seems to be caused by the injection itself,rather than by pentobarbital.

关键词： anesthesia pentobarbital intraperitoneal injection stress responses hypothalamo-pituitary-adrenal axis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：