检索结果-南通市图书馆

Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats

引用

Chinese Medical Journal 2007年第12期120卷 1088-1092页

作者： YIN Yan-yan MING Liang ZHENG Li-fang KAN Hong-wei LI Chun-ru LI Wei-ping Department of Pharmacology Anhui Medical University Hefei 230032 China Research Center of Entomogenous Fungi Anhui Agricultural University Hefei 230024 China

Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a potential antidepressant. In this study we aimed to study the antidepressant effects of BCPT in the chronic unpredictable stress （CUS） model in rats and explore underlying mechanisms in the hypothalamic-pituitary-adrenal （HPA） axis. Methods The antidepressant effects of BCPT were studied in the chronic unpredictable stress model in rats. Animals were housed isolated, except the control group. Rats were exposed daily to different random stressors from day 1 to 21. Awarding response was detected by calculating the 24-hour consumption of sucrose water. Cortisol （CORT） and adrenocorticotropic hormone （ATCH） contents in serum and arginine vasopressin （AVP） contents in the pituitary body were detected by radio immunoassays. Total RNA of hippocampus or hypothalamus was extracted and subjected to reverse transcription-polymerase chain reaction （RT-PCR） for the measurement of corticotrophin releasing hormone （CRH） mRNA or mineralocorticoid receptor （MR） mRNA and glucocorticoid receptor （GR） mRNA levels. Statistical analyses were performed using one way analysis of variance （ANOVA） followed by Student-Newman-Keuls （SNK） test. Results Chronic unpredictable stress resulted in reduction of sensitivity to reward and abnormality in the HPA axis in the animal model. BCPT improved the reward reaction as measured by increasing sucrose consumption, remarkably reduced serum CORT and ACTH levels and the AVP content in the pituitary body in the CUS-treated rats, decreased the expression of CRH mRNA, enhanced the expression of hippocampus MR mRNA, GR mRNA and decreased the ratio of MR/GR. Conclusions BCPT has potentially antidepressant-like activity and normalized the HPA axis hyperactivity in a CUS model of depression in rats. This may be an important mechanism of its antidepressan

关键词： Paecilomyces tenuipes depression stress hypothalamo-hypophyseal system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulative Actions of the Chinese Drugs for Tonifying the Kidney on Gene Expression of the Hypothalamic GnRH,Pituitary FSH,LH and Osteoblastic BGP

引用

Journal of Traditional Chinese Medicine 2005年第1期25卷 58-61,页

作者：蔡德培张炜王友京 Pediatric Hospital Affiliated to Shanghai Medical University Shanghai 200032China Shanghai Pasaike Bioengineering Institute

It is found that the drugs for nourishing yin to reduce pathogenic fire can significantly down-regulate,and the drugs for tonifying the kidney to replenish essence can up-regulate mRNA expression of the hypothalamic GnRH,pituitary FSH,LH and osteoblastic BGP,indicating that the Chinese drugs for tonifying the kidney can regulate gene expression of the hypothalamic GnRH,pituitary FSH,LH,and osteoblastic BGP,which is possibly one of the main mechanisms of the Chinese drug for tonifying the kidney,regulating ephebic development process and improving skeletal development in sexual precocity children.

关键词： Animals Drugs, Chinese Herbal Female Follicle Stimulating Hormone Gonadorelin hypothalamo-hypophyseal system Luteinizing Hormone Osteoblasts Pituitary Hormone-Releasing Hormones Proteins Puberty, Precocious RNA, Messenger Rats Rats, Sprague-Dawley Yin Deficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EFFECTS OF ACUPUNCTURE ON THE PITUITARYTHYROID AXIS IN RABBITS WITH FRACTURE

引用

Journal of Traditional Chinese Medicine 1999年第4期19卷 300-303页

作者：沈梅红祁晓华黄晔吕越蔡文辉王友京 The Second Clinical College of Nanjing University of Traditional Chinese Medicine and Pharmacy Nanjing 210029 The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine and Pharmacy

PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were randomly divided into the treatment group and control group, and the changes in serum T3, T4 and TSH contents in different weeks were investigated. RESULTS: Serum T3, T4 and TSH contents in the treatment group all were higher than those in the control group, with statistically significant differences in the contents of T4 and TSH in the second week and T3 content in the fourth week (P

关键词： Electroacupuncture Animals hypothalamo-hypophyseal system Male Rabbits Radius Fractures Random Allocation Thyroid Gland Thyrotropin Thyroxine Triiodothyronine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：