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hypopharyngeal cancer trends in a high-incidence region:A retrospective tertiary single center study

世界临床病例杂志 2023年第24期11卷 5666-5677页

作者： Alina-Georgiana Vulcu Cordunianu Gabriel Ganea Mihai Alexandru Cordunianu Daniel Cochior Cosmin Alec Moldovan Razvan Adam Doctoral School of Medicine Titu Maiorescu University of BucharestBucharest 040317Romania Department of Ear Nose Throat Head and Neck Surgery Carol Davila Central University Emergency Military HospitalBucharest 10825Romania Department of Pediatric Orthopedics Victor Gomoiu HospitalBucharest 022102Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu UniversityBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania

BACKGROUND hypopharyngeal cancer has the bleakest prognosis among head and neck cancers due to its extensive submucosal involvement,advanced tumor stage,and limited surgical reconstruction options.Its primary causes include alcohol consumption,tobacco use,genetic predisposition,1`diet,and socioeconomic conditions.While squamous cell carcinoma(SCC)accounts for 95%of hypopharyngeal tumors,it remains a rare form,comprising only 3%-5%of all SCC cases in the head and neck region.Globally,Central and Eastern Europe have the highest incidence rates for males(3.9 per 100000)and the third highest for females(2.26 per 100000),underscoring the significance of this seemingly uncommon condition.In Romania,hypopharyngeal cancer ranked 24th in incidence rate,with 634 new cases in 2020.AIM To study the incidence,treatment and survival rates of hypopharyngeal tumor cases in a major ear,nose,throat(ENT)surgical center.METHODS A retrospective epidemiological clinical study was conducted on patients diagnosed and treated for hypopharyngeal cancer at the ENT department of"Carol Davila Central University Emergency Military Hospital"in Bucharest between January 2018 and August 2022.The study included 53 patients and was authorized by the Ethics Committee of Titu Maiorescu Doctoral School(Bucharest,Romania)and the Ethics Committee of Carol Davila Central University Emergency Military Hospital(Bucharest,Romania).Inclusion criteria required a positive histopathological diagnosis of hypopharyngeal cancer,tumor localization in the hypopharyngeal region,and informed consent for data usage.Exclusion criteria involved major psychiatric pathologies and disagreement for data usage.Diagnosis was based on ENT assessment,imaging reports,and laboratory data.Treatment methods were determined based on various factors.Additional tools,such as Adult Comorbidity Evaluation-27 and Karnofski Performance Status Scale,were used for risk assessment and functional capacity evaluation.Quality of life aspects were measured using the European Organisation for Rea

关键词： hypopharyngeal Cancer Organ conservation therapy Chemotherapy Radiotherapy Surgery

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Survival differences between definitive radiotherapy and surgery followed by adjuvant radiotherapy in supraglottic and hypopharyngeal carcinoma

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Chinese Medical Journal 2019年第22期132卷 2698-2704页

作者： Min Zhang Xian-Shu Gao Yong Qin Yue Sun Ming-Wei Ma Department of Radiation Oncology Peking University First HospitalPeking UniversityBeijing 100034China Department of Otorhinolaryngology-Head and Neck Surgery Peking University First HospitalBeijing 100034China Department of Otorhinolaryngology Peking University Shougang HospitalBeijing 100144China

Background:Organ preservation has long been a consideration in the treatment of supraglottic and hypopharyngeal carcin improve the quality of life(QOL).Definitive radiotherapy(DRT)with or without systematic treatment,such as chemotherapy,is always the first choice to achieve improved QOL.This retrospective study focused on the survival differences between DRT and surgery followed by adjuvant radiotherapy(S+RT)in supraglottic and hypopharyngeal carcinoma.Methods:This study included adult patients with supraglottic or hypopharyngeal carcinoma undergoing single-modality treatment with either DRT or S+RT between January 2012 and August 2016.A total of 59 patients were identified,of whom 31 were treated with DRT,and 28 were treated with S+RT.In the 31 cases of DRT,23 cases were treated with concurrent chemoradiotherapy(CRT),one case was treated with DRT plus cetuximab,and seven cases were treated with DRT alone.Of the other 28 cases of S+RT,15 cases were treated with adjuvant concurrent CRT.Survival analysis was used to compare the overall survival(OS),local recurrence-free survival(LRFS)and distant metastasis-free survival(DMFS)between DRT and S+RT groups.Results:The median follow-up was 20 months(range,4-67 months).The patients of the two groups were similar with respect to mean age,original sites,and tumor stages.The 1-,2-,and 5-year OS rates were 80.6%,53.4%,and 24.7% for the DRT group and 85.7%,67.1%,and 24.7%for the S+RT group,respectively.There was no significant difference between the two groups(x^2=3.183,P=0.074).The 1-,2-,and 5-year LRFS and DMFS were 90.4%,61.7%,and 18.0%and 87.4%,49.2%,and 9.9%,respectively,and no statistical difference was observed between the two groups(LRFS:x^2=0.028,P=0.868;DMFS:x^2=3.347,P=0.067).No significant difference was found between the two groups in acute radiotoxicity.Conclusions:Without loss of laryngeal function,the survival of DRT is comparable to that of S+RT in supraglottic and hypopharyngeal carcinoma.

关键词： Supraglottic hypopharyngeal Definitive radiotherapy Adjuvant radiotherapy Survival

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Surgical resection of a large hypopharyngeal hemangioma in an adult using neodymium-doped yttrium aluminum garnet laser: A case report

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World Journal of Clinical Cases 2020年第5期8卷 932-938页

作者： Mang Jin Cheng-Yu Wang Yun-Xiang Da Wei Zhu Hui Jiang Department of Otolaryngology Jinshan Hospital Fudan University

BACKGROUND Generally,hemangiomas do not require surgical intervention;however,cases of large hemangiomas,potentially involving the throat and trachea,necessitate surgical therapy.Here,we present a case of hypopharyngeal hemangioma in an adult that was successfully treated with neodymium-doped yttrium aluminum garnet(Nd-YAG)laser.CASE SUMMARY Laryngoscopic examination of a 61-year-old man demonstrated the presence of a large,submucosal vascular lesion that extended into the epiglottis,left arytenoid cartilage,lateral to the aryepiglottic fold,and pyriform sinus.The lesion was resected and photocoagulated with limited hemorrhage using Nd:YAG laser.The hypopharyngeal hemangioma was completely excised.The patient showed no recurrence of hypopharyngeal hemangioma during the 1.5-year follow-up period.CONCLUSION Laser therapy is one of the effective tools for treating hemangiomas with rapid,uncontrolled growth or in functional areas,with few side effects and complications.The present case of a male patient with a large hypopharyngeal hemangioma,treated with YAG laser,demonstrates the efficacy of laser photocoagulation in treating cases of hemangiomas,without the risk of bleeding or airway obstruction.The favorable postoperative outcomes demonstrated by our patient with Nd:YAG laser therapy indicate its consideration in the therapy of similar cases.

关键词： Yttrium aluminum garnet laser Large Adult Surgical resection hypopharyngeal Hemangioma Case report

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Slide Pharyngo-Esophagostomy Following Ablation of hypopharyngeal Cancer

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Surgical Science 2017年第9期8卷 403-406页

作者： Ming-Ho Wu Han-Yun Wu Department of Surgery Tainan Municipal Hospital Taiwan

We describe a procedure of slide pharyngo-esophagoplasty for restoration following ablation of hypopharyngeal cancer in a 99 year-old man. The elderly presented to our hospital with 2-month dysphagia, occasional bloody salivation, and 2-day respiratory distress. To solve the problems of swallowing difficulty and dyspnea, he underwent laryngopharyngectomy, permanent tracheostomy, and slide pharyngo-esophagoplasty. The patient was uneventful after the restoration procedure.

关键词： hypopharyngeal Cancer Laryngopharyngectomy Slide Pharyngo-Esophagoplasty

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A Case of Simultaneous Triple Primary Cancers of the Hypopharynx, Esophagus, and Stomach Which Were Dissected by Endoscopic Laryngo-Pharyngeal Surgery Combined with Endoscopic Submucosal Dissection

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Open Journal of Gastroenterology 2018年第3期8卷 94-102页

作者： Kenro Kawada Taro Sugimoto Ryuhei Okada Kazuya Yamaguchi Yuudai Kawamura Masafumi Okuda Yuuichiro Kume Andres Mora Tairo Ryotokuji Takuya Okada Akihiro Hoshino Yutaka Tokairin Yasuaki Nakajima Yusuke Kiyokawa Fuminori Nomura Yoshuke Ariizumi Shohei Tomii Takashi Ito Takahiro Asakage Yusuke Kinugasa Tatsuyuki Kawano Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan Department of Head and Neck Surgery Tokyo Medical and Dental University Tokyo Japan Department of Human Pathology Tokyo Medical and Dental University Tokyo Japan

A 65-year-old man was admitted to our hospital following 6 months of dysphagia. At first, conventional endoscopy showed a reddish and depressed lesion in the stomach and an elevated lesion in the posterior wall of the hypopharynx. An endoscopic biopsy showed adenocarcinoma in the stomach, and squamous cell carcinoma in the hypopharynx. On the further examination, trans-nasal endoscopy with narrow band imaging (NBI) was performed. During the trumpet maneuver, a huge protruded lesion was observed and it reached to the orifice of the esophagus. Other superficial lesion located at left pyriform sinus was detected by NBI system as brownish area with brown dots. Furthermore, superficial esophageal cancer in the cervical esophagus was detected. Finally, 4 carcinomas in upper gastrointestinal tract were detected. Among them, the hypopharyngeal cancer was the most advanced (T3N0). The patient hoped to preserve his voice and swallowing function, endoscopic laryngo-pharyngeal surgery (ELPS) was performed for the hypopharyngeal cancer. Endoscopic mucosal resection (EMR) was performed for the esophageal cancer, and Endoscopic submucosal dissection (ESD) was performed for the gastric cancer. Under collaboration between a head and neck surgeon and an endoscopist, the tumor was resected en-bloc. The histopathological findings of hypopharyngeal cancer were squamous cell carcinoma, subeipthelial invasion, 29 × 28 × 4.2 mm. The others were diagnosed as mucosal cancers. The patient is currently alive with no recurrence at 28 months after the surgery;there is no stricture at the cervical esophagus. Endoscopic laryngopharyngeal surgery for the tumor of pharyngo-esophageal junction can provide a less invasive treatment.

关键词： Endoscopic Laryngopharyngeal Surgery hypopharyngeal Cancer Multiple Primary Cancer Trumpet Maneuver Endoscopic Submucosal Dissection

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