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CT-Scan Findings of Hepatic Mass Patients Attending at a Tertiary Care Hospital in Bangladesh

Open Journal of Radiology 2016年第1期6卷 56-61页

作者： Wahida Begum Nazrul Islam Mahbuba Begum Shayma Sultana Md. Abdullah Yusuf Khondker Shaheed Hussain Sabina Jesmin Department of Neuroradiology & Imaging National Institute of Neurosciences & Hospital Dhaka Bangladesh Department of Surgery Uttara Women’s Medical College Dhaka Bangladesh International Centre for Diarrhoeal Disease Research Dhaka Bangladesh Department of Microbiology National Institute of Neurosciences & Hospital Dhaka Bangladesh Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Pharmacology National Institute of Neurosciences & Hospital Dhaka Bangladesh

Background: CT-scan is a very useful diagnostic tool for the detection of hepatic mass. Objective: The present study was undertaken to determine the CT-scan findings of benign and malignant hepatic mass patients. Methodology: This was a cross sectional study conducted in Radiology and Imaging Department at Mymensingh Medical College Hospital (MMCH), Mymensingh;Dhaka Medical College Hospital (DMCH), Dhaka and Banghabandhu Sheikh Mujib Medical University (BSMMU), Dhaka with the collaboration of Pathology Department of the same institute for histopathological confirmation. This study was carried out from January 2006 to December 2007 for a period of 2 years. The patients who were clinically suspected of having hepatic mass attended in the Radiology and Imaging Department in the above mentioned institutes were included as study population. All the CT-scan findings were recorded. Result: A total number of 50 patients were enrolled for this study. CT-scan was done among 40 males and 10 females with a mean age of 51.28 years old. hypodensity was found in 17 (60.7%) and 18 (81.8%) cases in malignant and benign hepatic lesions respectively. Ill-defined margin was detected in 12 (42.9%) and 6 (27.3%) cases respectively. Calcification was present on 11 (39.3%) malignant lesion and 6 (27.3%) benign lesions. Pressure effect on biliary apparatus was found in 11 (39.3%) malignant lesions and 1 (4.5%) benign lesions (p hypodensity with more contrast enhancement in malignant lesions with more calcification in malignant lesion;however, significant difference is detected in pressure effect on biliary apparatus and lymphadenopathy.

关键词： Hepatic Mass CT-Scan Hepatomegaly Calcification hypodensity

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Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy

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World Journal of Hepatology 2015年第6期7卷 910-915页

作者： Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre Department of Medical Oncology Beaujon University Hospital (AP-HP-PRES Paris 7 Diderot) Department of Hepatology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Imaging Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Biliary and Pancreatic Surgery Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Pathology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot)

Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327).

关键词：胆汁的道肿瘤 Antiangiogenic 治疗 hypodensity 肿瘤反应脉管的 endothelial 生长因素受体禁止者 Chemoresistance

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