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hypnotic effects of A Novel Anti-Insomnia Formula on Drosophila Insomnia Model

Chinese Journal of Integrative Medicine 2016年第5期22卷 335-343页

作者：高俊熙官志文余兆龙李国英刘碧珊陈浩然荣润国冯国培梁秉中 Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Photochemistry and Plant Resources in West China The Chinese University of Hong Kong School of Life Sciences The Chinese University of Hong Kong Department of Psychiatry The Chinese University of Hong Kong School of Biomedical Sciences The Chinese University of Hong Kong

Objective： To assess the biological effects of the six-herb mixture Anti-lnsomia Formula （AIF） extract using caffeine-induced insomnia Drosophila model and short-sleep mutants. Methods： Caffeine- induced insomnia wild-type Drosophila and short-sleep mutant flies minisleep （runs） and Hyperkinetic Y（Hk Y） were used to assess the hypnotic effects of the AIF in vivo. The night time activity, the amount of night time sleep and the number of sleep bouts were determined using Drosophila activity monitoring system. Sleep was defined as any period of uninterrupted behavioral immobility （0 count per minute） lasting 〉 5 min. Night time sleep was calculated by summing up the sleep time in the dark period. Number of sleep bouts was calculated by counting the number of sleep episodes in the dark period. Results： AIF at the dosage of 50 mg/mL, effectively attenuated caffeine-induced wakefulness （P〈0.01） in wild-type Canton-S flies as indicated by the reduction of the sleep bouts, night time activities and increase of the amount of night time sleep. AIF also significantly reduced sleeping time of short-sleep Hk y mutant flies （P〈0.01）. However, AIF did not produce similar effect in mns mutants. Conclusion： AIF might be able to rescue the abnormal condition caused by mutated modulatory subunit of the tetrameric potassium channel, but not rescuing the abnormal nerve firing caused by Shaker gene mutation. This study provides the scientific evidence to support the use of AIF in Chinese medicine for promoting sleep quality in insomnia.

关键词： caffeine hypnotic effects Ziziphus jujube Polygonum multiflorum Poria cocos Triticum aestivu Anemarrhena asphodeloides Polygala tenuifolia Chinese medicine

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Involvement of brain serotonergic system in Ganoderma Lucidum Extraction induced sleep

Involvement of brain serotonergic system in Ganoderma Lucidu...

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中国药理学会第十次全国学术会议

作者： Xiang-Yu Cui~a,Su-Ying Cui~a,Guo-Rong He~b,Lian-Hua Fang~b,Guan-Hua Du~b,Yong-He Zhang~(*a) (a Department of Pharmacology,School of Basic Medical Science,Peking University,38 Xue YuanLu Rd,Beijing 100191,China b Insitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,1 XianNongTan St,Beijing 100050)

Our pervious study indicated that GLE(Ganoderma Lucidum Extract) may have benzodiazepine-like hypnotic activity to some *** China,Ganoderma lucidum has been used as a tranquilizing agent to treat insomnia for thousands of years,although its mechanism remains *** a traditional Chinese herb preparation, GLE may regulate sleep through multi-pathway activation besides GABAergic system.

关键词： Ganoderma Lucidum Extract hypnotic effects GABAergic System Serotonergic system

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