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Natremia and liver transplantation:The right amount of salt for a good recipe

World Journal of Hepatology 2020年第11期12卷 919-930页

作者： Ilaria Lenci Martina Milana Giuseppe Grassi Alessandro Signorello Andrea Aglitti Leonardo Baiocchi Department of Internal Medicine Hepatology UnitTor Vergata UniversityRome 00133Italy

An adequate balance between electrolytes and clear water is of paramount importance to maintaining physiologic *** imbalance and,in particular,hyponatremia is the most frequent electrolyte abnormality observed in hospitalized subjects,involving approximately one-fourth of *** changes occurring during liver cirrhosis predispose patients to an increased risk of sodium imbalance,and hypervolemic hyponatremia has been reported in nearly 50%of subjects with severe liver disease and *** vasodilatation,portal-systemic collaterals’opening and increased excretion of vasoactive modulators are all factors impairing clear water handling during liver *** concern,sodium imbalance has been consistently reported to be associated with increased risk of complications and reduced survival in liver disease *** the last decades clinical interest in sodium levels has been also extended in the field of liver *** that[Na+]in blood is an independent risk factor for in-list mortality led to the incorporation of sodium value in prognostic scores employed for transplant priority,such as model for end-stage liver disease-Na and *** the other hand,severe hyponatremic cirrhotic patients are frequently delisted by transplant centers due to the elevated risk of mortality after *** this review,we describe in detail the relationship between sodium imbalance and liver cirrhosis,focusing on its impact on peritransplant *** possible therapeutic approaches,in order to improve transplant outcome,are also discussed.

关键词： Sodium imbalance Liver transplant Cirrhosis Vaptan Transplant list hypervolemic hyponatremia

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