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Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

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World Journal of Clinical Cases 2024年第11期12卷 1918-1928页

作者： Hai-Fu Zhang Ze-Xuan Su Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is increasing.Due to its relatively insidious etiology,it is easy to be ignored in the early stages.In China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating AP.AIM To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were collected.The changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two groups.RESULTS Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with CQCQD.After receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,Pacute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,P<0.01).CONCLUSION In patients with HTG-AP,CQCQD can significantly reduce the TG level,shorten the recovery time of defecation,significantly improve the gastrointestinal function.

关键词： hypertriglyceridemic acute pancreatitis Chinese medicine Chaiqin Chengqi Decoction Serum lipid Triglycerides

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Incidence and clinical characteristics of hypertriglyceridemic acute pancreatitis:A retrospective single-center study

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World Journal of Gastroenterology 2022年第29期28卷 3946-3959页

作者： Xue-Yan Lin Yi Zeng Zheng-Chao Zhang Zhi-Hui Lin Lu-Chuan Chen Zai-Sheng Ye Department of Gastroenterology Fujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina Department of Gastrointestinal Surgical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Emergency Surgery Fujian Provincial HospitalFujian Medical University Provincial of Clinical MedicineFuzhou 350001Fujian ProvinceChina

BACKGROUND The incidence of hypertriglyceridemic acute pancreatitis(HTG-AP)has increased yearly,but updated population-based estimates on the incidence of HTG-AP are lacking.Reducing serum triglyceride(TG)levels quickly is crucial in the early treatment of HTG-AP.Decreased serum TG levels are treated by non-invasive methods,which include anti-lipidemic agents,heparin,low-molecular weight heparin,and insulin,and invasive methods,such as blood purification including hemoperfusion(HP),plasmapheresis,and continuous renal replacement therapy.However,authoritative guidelines have not been established.Early selection of appropriate treatment is important and beneficial in controlling the development of HTG-AP.AIM To evaluate the effect between patients treated with intravenous insulin(INS)and HP to guide clinical treatment.METHODS We retrospectively reviewed 371 patients with HTG-AP enrolled in the Department of Fujian Provincial Hospital form April 2012 to March 2021.The inpatient medical and radiologic records were reviewed to determine clinical features,severity,complications,mortality,recurrence rate,and treatment.Multivariate logistic regression analyses were used to analyze risk factors for severe HTG-AP.Propensity score matching was used to compare the clinical outcomes of INS and HP.RESULTS A total of 371 patients met the HTG-AP criteria.The incidence of HTG-AP was increased by approximately 2.6 times during the 10 years(8.4%in April 2012-March 2013 and 22.3%in April 2020-March 2021).The highest incidence rate of acute pancreatitis was observed for men in the age group of 30-39 years.The amylase level was elevated in 80.1%of patients but was only three times the normal value in 46.9%of patients.The frequency of severe acute pancreatitis(26.9%),organ failure(31.5%),rate of recurrence(32.9%),and mortality(3.0%)of HTG-AP was high.Improved Marshall score,modified computed tomography severity index score,baseline TG,baseline amylase,C-reactive protein(CRP),albumin,aspartate aminotransferase,low-density lipoprotein ch

关键词： hypertriglyceridemic acute pancreatitis Triglyceride Improved Marshall score Severity of acute pancreatitis Intravenous insulin Hemoperfusion

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Incidence and clinical treatment of hypertriglyceridemic acute pancreatitis:A few issues

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World Journal of Clinical Cases 2023年第2期11卷 479-481页

作者： Qun-Ying Yang Qian Zhao Jian-Wen Hu Department of Gastroenterology Dongyang People's HospitalDongyang 322100Zhejiang ProvinceChina

Hypertriglyceridemia is a well-recognized etiology of acute pancreatitis,and the incidence of hypertriglyceridemic acute pancreatitis(HTG-AP)has increased in frequency worldwide in response to lifestyle changes.It is crucial to identify hypertriglyceridemia as the cause of pancreatitis and initiate appropriate treatment.Insulin treatment produces effective lowering of triglycerides,but in our opinion,non-diabetic patients with HTG-AP require separate consideration to avoid hypoglycemia.

关键词： hypertriglyceridemic acute pancreatitis Incidence Etiology Insulin Treatment

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