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Undescribed Meroterpenoids from hypericum japonicum with Neuroprotective Effects on H_(2)O_(2) Insult SH-SY5Y Cells Targeting Keap1-Nrf2

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Chinese Journal of Chemistry 2022年第11期40卷 1321-1330页

作者： Linzhen Hu Zhenzhen Wang Zhou Tong Ping Hu Luqi Kong Mengying Luo Xiao-Nian Li Yuexing Zhang Zhiyong Huang Yonghui zhang State Key Laboratory of Biocatalysis and Enzyme Engineering National&Local Joint Engineering Research Centre of High-throughput Drug Screening TechnologyHubei Key Laboratory of Biotechnology of Traditional Chinese MedicineSchool of Life SciencesHubei UniversityWuhanHubei 430062China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Kunming Institute of Botany Chinese Academy of SciencesKunmingYunnan 650204China College of Chemistry and Chemical Engineering Hubei UniversityWuhanHubei 430062China Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences.Tianjin 300308China

Unreported tautomeric/enantiomeric meroterpenoids,(±)-hyperjaponols I—K(1-3),were discovered from hypericum *** chemical investigations established the absolute characteristics of these *** TS calculation demon-strated that 1a and 2a easily occur enol-keto tautomerism with steady configurations *** isolates,1b showed the strongest neuroprotective activity with the concentration at 25μmol/L on H_(2)O_(2) insult SH-SY5Y *** vitro molecular biological ex-periments manifested that 1b activated the Keap1-Nrf2-ARE pathway,leading to the promotion of Nrf2 nuclear translocation,down-regulation of the expression level of Keap1,and upregulation of the levels of Nrf2,NQO-1,and *** results of in silico simulation showed that 1b possessed good binding features with Keap1(5FNQ)via forming multiple typical hydrogen and hydrophobic bonds as well as less fluctuation of RMSD and RMSF during a natural physiological condition.

关键词： hypericum japonicum Natural products Tautomerism Neuroprotective activity Keap1-Nrf2-ARE pathway

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New Phloroglucinol Glycosides from hypericum japonicum

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Chinese Chemical Letters 1998年第5期9卷 469-470页

作者： Qing Li WU Sheng Ping WANG Li Wei WANG Jun Shan YANG Pei Gen XIAO(Institute of Medicinal Plant Development, Chinese Academy of Medical Sciencesand Peking Union Medical College, Bejing 100094) Inst. of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical Colleg Beijing 100094 China

Two new phloroglucinol glycosides, 2,6-dihydroxy-3,5-dimethyl-1-isobutyrylbenzene-4-O-beta-D-glucoside and 2,6-dihydroxy-3,5-dimethyl-1-(2-methylbutyryl) benzene-4-O-beta-D-glucoside were isolated from hypericum japon... 详细信息

关键词： hypericum japonicum Guttiferae phloroglucinol glycoside 2-methyl-1-(2,6-dihydroxy-3,5-dimethylphenyl)-1-propanone-4-O-beta-D-glucoside 2-methyl-1-(2,6-dihydroxy-3,5-dimethyl phenyl)-1-butanone-4-O-beta-D-glucoside

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A New Bisxanthone from hypericum japonicum *** Murray

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Chinese Chemical Letters 2005年第6期16卷 771-773页

作者： PengFU WeiDongZHANG TingZhaoLI RunHuiLIU HuiLiangLI WeiZHANG HaiShengCHEN DepartmentofNaturalMedicinalChemistry SchoolofPharmacySecondMilitaryMedicalUniversityShanghai200433

A new bisxanthone, named bijaponicaxanthone C, was isolated from the whole plant of hypericum japonicum. The structure was elucidated as 6-[1’’,5’’,6’’-trihydroxy-2’’’-(β-hydroxy-β- methylethyl)-2’’’,3’’’-dihydrofuran(5’’’,4’’’,3’’,4’’)xanthone-3’’’-oxyl]-1,3,5-trihydroxy-4-isoprenylxant- hone (1) on the basis of the spectral and chemical evidences.

关键词： hypericum japonicum bisxanthone 6-[1'' 5'' 6''-trihydroxy-2'''-(β-hydroxy-β-methyl- ethyl)-2''' 3'''-dihydrofuran(5''' 4''' 3'' 4'')xanthone-3'''-oxyl]-1 3 5-trihydroxy-4-isoprenylxanthone bijaponicaxanthone C.

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