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hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury

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Burns & Trauma 2020年第1期8卷 186-203页

作者： Jiro Oba Motonori Okabe Toshiko Yoshida Chika Soko Moustafa Fathy Koji Amano Daisuke Kobashi Masahiro Wakasugi Hiroshi Okudera Department of Emergency and Disaster Medicine University of ToyamaToyama 930-0194Japan Department of Regenerative Medicine Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-0194Japan Department of Biochemistry Faculty of PharmacyMinia UniversityMinia 61519Egypt Department of Emergency Surgery Sakai City Medical CenterSakaiOsaka 594-8304Japan

Background:Severe burn injuries create large skin defects that render the host susceptible to bacterial *** wound infection often causes systemic sepsis and severe septicemia,resulting in an increase in the mortality of patients with severe burn ***,appropriate wound care is important to prevent infection and improve patient ***,it is difficult to heal a third-degree burn *** aim of this studywas to investigate whether hyperdry human amniotic membrane(HD-AM)could promote early granulation tissue formation after full-thickness skin excision in third-degree burn injury sites in ***:After the development of HD-AM and creation of a third-degree burn injury model,the HD-AM was either placed or not placed on the wound area in the HD-AM group or HD-AM group,*** groups were prepared for evaluation on postoperative days 1,4 and *** staining was used for granulation tissue evaluation,and estimation of CD163,transforming growth factor beta-1(TGF-β1),vascular endothelial growth factor(VEGF),CD31,alpha-smooth muscle actin(α-SMA)and Iba1 expression was performed by immunohistochemical *** reverse-transcription polymerase chain reaction(PCR)was used to investigate gene expression of growth factors,cell migration chemokines and angiogenic and inflammatory ***:The HD-AM group showed significant early and qualitatively good growth of granulation tissue on the full-thickness skin excision ***-AM promoted early-phase inflammatory cell infiltration,fibroblast migration and angiogenesis in the granulation ***,the early infiltration of cells of the immune system was ***:HD-AM may be useful as a new wound dressing material for full-thickness skin excision sites after third-degree burn injuries,and may be a new therapeutic technique for improving the survival rate of patients with severe burn injuries.

关键词： hyperdry human amniotic membrane Third-degree burn Granulation Cell migration Inflammation Angiogenesis

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