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Ischemic colitis induced by the newly reformulated multicomponent weight-loss supplement hydroxycut~

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World Journal of Gastrointestinal Endoscopy 2013年第4期5卷 180-185页

作者： Muhammed Sherid Salih Samo Samian Sulaiman Joseph H Gaziano Department of Internal Medicine Division of Gastroenterology CGH Medical Center Department of Internal Medicine Division of Gastroenterology Saint Francis Hospital

Ischemic colitis accounts for 6%-18% of causes of acute lower gastrointestinal bleeding. It is more often multifactorial and more common in elderly. Drugs are considered important causative agents of this disease with different mechanisms. In this paper, we describe a 37-year-old otherwise healthy female presented with sudden onset diffuse abdominal pain and bloody stool. Radiologic, colonoscopic and histopathologic findings were all consistent with ischemic colitis. Her only suspected factor was hydroxycut which she had been taking for a period of 1 mo prior to her presentation. Her condition improved uneventfully after cessation of hydroxycut, bowel rest, intravenous hydration, and antibiotics. This is a first case of ischemic colitis with clear relationship with hydroxycut use (Naranjo score of 7). Our case demonstrates the importance of questioning patients regarding the usage of dietary supplements; especially since many patients consider them safe anddo not disclose their use voluntarily to their physicians. hydroxycut has to be considered as a potential trigger for otherwise unexplained ischemic colitis.

关键词： hydroxycut Weight-loss supplement Herbal Ischemic colitis Gastrointestinal bleeding Colonoscopy

Acute liver injury induced by weight-loss herbal supplements

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World Journal of Hepatology 2010年第11期2卷 410-415页

作者： Gary C Chen Vivek S Ramanathan David Law Pauline Funchain George C Chen Samuel French Boris Shlopov Viktor Eysselein David Chung Sonya Reicher Binh V Pham Department of Gastroenterology and Pathology Harbor UCLA Medical Center

We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onstrated f indings consistent with drug-induced acute liver injury. To our knowledge, we are the fi rst instit ute to report acute liver injury from both of these two typ es of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supp lements for the purpose of weight loss.

关键词： hydroxycut Herbalife Hepatotoxicity Herbal Weight-loss

Hepatoxicity associated with weight-loss supplements: A case for better post-marketing surveillance

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World Journal of Gastroenterology 2009年第14期15卷 1786-1787页

作者： Ano Lobb Public Health Consultant 80 Lepage Rd Barre VT 05641 United States

There is a growing number of case reports of hepatoxicity from the widely marketed weight-loss supplement hydroxycut, which contains the botanical ingredient Garcinia cambogia . These case reports may substantially undercount the true magnitude of harm. Based on the past experience with harmful dietary supplements, US regulators should assume the more precautionary approach favored by Canada and Europe. Lacking effective adverse event surveillance for supplements, or the requirements to prove safety prior to coming to the market, case reports such as those summarized here assume added importance.

关键词： hydroxycut Dietary supplements Garciniacambogia Liver failure Weight loss Super citrimax Hca-sx

No evidence demonstrating hepatotoxicity associated with hydroxycitric acid

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World Journal of Gastroenterology 2009年第32期15卷 4087-4089页

作者： Sidney J Stohs Harry G Preuss Sunny E Ohia Gilbert R Kaats Carl L Keen Lonnie D Williams George A Burdock School of Pharmacy and Health Professions Creighton University Medical Center4967 Stillwater TrailFriscoTX 75034United States

Although a number of cases of hepatotoxicity are associated with the use of hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingredients, some do not contain HCA. Case studies reported to date have not considered in depth the literature on the numerous animal and human studies that have been conducted on the safety and effi cacy of HCA. No HCA-associated hepatotoxicity or treatment-related adverse effects have been reported in these studies, and thus it is premature to make the assumptions presented in the recent case studies regarding hydroxycut. If it is established in well controlled studies that the use of these formulations with and/or without HCA can result in the occurrence or progression of hepatotoxicity, additional studies should be conducted to characterize the causative factor(s).

关键词： Hydroxycitric acid Super CitriMax Hydroxycitric acid-SX Garcinia cambogia hydroxycut Liver failure Hepatotoxicity Safety and efficacy

Science of weight loss supplements:Compromised by conflicts of interest?

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World Journal of Gastroenterology 2010年第38期16卷 4880-4882页

作者： Ano Lobb the Dartmouth Institute Dartmouth Medical School35 Centerra Parkway

Weight loss supplements often contain powerful pharmacoactive ingredients with the potential to cause harm. Trials used to determine product safety and effectiveness, meanwhile,tend to be small, of short duration, and frequently lack financial conflict of interest disclosures. These factors could conspire to place consumers at risk, especially when published research cited in advertising cloaks products with the suggestion that their safety and effectiveness have been proven by science. Examples of current and former weight loss products backed by potentially con? icted or low quality research include Metabolife-356, hydroxycut, Xenadrine and LeptiCore. Published research, especially in the field of weight loss supplements, needs better conflict of interest disclosure, and regulators should consider how research f indings are used in marketing claims.

关键词： Weight loss supplements Cissus quadrangularis hydroxycut Xenadrine Metabolife Lepticore Garcinia cambogia Con ict of interest