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Accurate and sensitive determination of hydroxychloroquine sulfate used on COVID-19 patients in human urine,serum and saliva samples by GC-MS

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Journal of Pharmaceutical Analysis 2021年第3期11卷 278-283页

作者： Süleyman Bodur Sezin Erarpat Omer Tahir Günkara Sezgin Bakırdere Yıldız Technical University Faculty of Art and ScienceDepartment of Chemistry34210DavutpasaEsenlerIstanbulTurkey Turkish Academy of Sciences(TÜBA) Piyade Sokak No:27Çankaya06690AnkaraTurkey

A rapid,accurate,and sensitive analytical method,ultrasonication-assisted spraying based fine droplet formationeliquid phase microextractionegas chromatographyemass spectrometry(UA-SFDF-LPME-GCMS),was proposed for the determination of trace amounts of hydroxychloroquine sulfate in human serum,urine,and saliva *** determine the best extraction strategy,several liquid and solid phase extraction methods were investigated for their efficiencies in isolation and preconcentration of hydroxychloroquine sulfate from biological *** UA-SFDF-LPME method was determined to be the best extraction method as it was operationally simple and provided accurate *** such as the extraction solvent,spraying number,sodium hydroxide concentration and volume,sample volume,mixing method,and mixing period were optimized for the proposed method using the onevariable-at-a-time *** addition,Tukey’s method based on a post hoc comparison test was employed to evaluate the significant difference between the parameters *** the optimization studies,the limit of detection(LOD)and limit of quantification(LOQ)were determined to be 0.7 and 2.4 mg/kg,*** sensitivity of the GC-MS system based on the LOD was enhanced approximately 440-fold when the UA-SFDF-LPME method was *** experiments were also conducted for the human serum,urine,and saliva samples to determine the applicability and accuracy of the proposed *** for the human serum,urine,and saliva samples were found to be in the ranges of 93.9%-101.7%,95.2%-105.0%,and 93.1%-102.3%,*** results were satisfactory and indicated that the hydroxychloroquine sulfate level in the above biological samples could be analyzed using the proposed method.

关键词： hydroxychloroquine sulfate GC-MS Biological samples Dispersive solid phase extraction Liquid phase microextraction

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