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Platelet rich plasma-complexed hydrogel glue enhances skin wound healing in a diabetic rat model

BIOCELL 2022年第5期46卷 1329-1338页

作者： YUNLONG ZHANG JINGWEI ZHANG YU ZHU BIN CAI Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Department of Orthopedics Shanghai Fengxian District Central Hospital/Southern Medical University Affiliated Fengxian HospitalShanghai201400China

Diabetic patients often exhibit delayed or incomplete progress in the healing of acute wounds,owing to poor blood ***-rich plasma(PRP)has attracted much attention as a means to improve wound healing,because it contains high growth factor ***,the burst-like release of PRP growth factors results in a short halflife of these therapeutic proteins,thus greatly limiting the therapeutic *** this study,we prepared PRP from human umbilical cord blood and developed an in situ photocrosslinkable PRP hydrogel glue(HNPRP)by adding a photoresponsive hyaluronic acid(HA-NB)into *** HNPRP hydrogel allowed for controlled release of plateletderived growth factor-BB(PDGF-BB)and transforming growth factor-β(TGF-β)for up to 28 *** vitro cell culture showed that HNPRP promoted migration of fibroblasts and keratinocytes as well as PRP and did not reveal the advantages of ***,in a diabetic rat skin wound model,HNPRP treatment promoted faster wound ***,the HNPRP group,compared with the control,PRP and hydrogel only groups,showed significantly greater re-epithelialization and numbers of both newly formed and mature blood *** HNPRP group also displayed higher collagen formation than did the control *** conclusion,HNPRP enhances angiogenesis and skin regeneration and consequently achieves faster wound healing,thus extending its potential for clinical applications to treat diabetic skin wounds.

关键词： Platelet-rich plasma Wound healing Umbilical cord blood hydrogel glue Angiogenesis

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