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hydrodynamic modeling of ferrofluid flow in magnetic targeting drug delivery

Applied Mathematics and Mechanics(English Edition) 2008年第10期29卷 1341-1349页

作者：刘菡萏徐威王石刚柯遵纪 School of Mechanical Engineering Shanghai Jiaotong University Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Among the proposed techniques for delivering drugs to specific locations within human body, magnetic drug targeting prevails due to its non-invasive character and its high targeting efficiency. Magnetic targeting drug delivery is a method of carrying drug-loaded magnetic nanoparticles to a target tissue target under the applied magnetic field. This method increases the drug concentration in the target while reducing the adverse side-effects. Although there have been some theoretical analyses for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel. A mathematical model is presented to describe the hydrodynamics of ferrofiuids as drug carriers flowing in a blood vessel under the applied magnetic field. In this model, magnetic force and asymmetrical force are added, and an angular momentum equation of magnetic nanoparticles in the applied magnetic field is modeled. Engineering approximations are achieved by retaining the physically most significant items in the model due to the mathematical complexity of the motion equations. Numerical simulations are performed to obtain better insight into the theoretical model with computational fluid dynamics. Simulation results demonstrate the important parameters leading to adequate drug delivery to the target site depending on the magnetic field intensity, which coincident with those of animal experiments. Results of the analysis provide important information and suggest strategies for improving delivery in clinical application.

关键词： magnetic targeting drug delivery ferrofluids magnetic nanoparticles hydrodynamic modeling CFD simulation

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Salinity Distribution at Canal Istanbul and Its Possible Impacts on the Northern Marmara Sea

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China Ocean Engineering 2020年第6期34卷 881-888页

作者： Şehriban SAÇU Tarkan ERDIK OlgayŞEN Istanbul Technical University MaslakIstanbul 34467Turkey

Turkey has announced its plan to construct a new waterway, Canal Istanbul, parallel to the Bosphorus. In this study,the influence of Canal Istanbul on salinity distribution in the northern Marmara Sea is investigated using a previously calibrated 3 D hydrodynamic and salinity model. Moreover, the salinity field of the canal and its propagation are examined based on various meteorological cases. Finally, the flow structure of the canal is determined. It is calculated that at the southern end of the canal, mainly unidirectional flow(from the Black Sea to the Marmara Sea)occurs during 68% of the simulation period. A two-layer flow is seen only 28% of the time with a weak lower layer flow, whereas this value decreases to 4% at the north end of the canal. In the southward direction(to the Marmara Sea), velocities higher than 1.5 m/s are rarely observed along the canal. The average surface salinity difference in the northern Marmara Sea due to the construction of the canal is calculated to be smaller than 0.50 ppt. The salinity difference gradually diminishes as water depth increases and after 25 m(from the surface) almost no difference is observed.

关键词： Canal Istanbul Marmara Sea salinity distribution hydrodynamic modeling

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modeling and analysis of an underwater biomimetic vehicle-manipulator system

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Science China(Information Sciences) 2022年第3期65卷 255-257页

作者： Xuejian BAI Yu WANG Shuo WANG Rui WANG Min TAN Wei WANG School of Artificial Intelligence University of Chinese Academy of Sciences State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence Technology School of Control Science and Engineering Shandong University

In recent years, underwater vehicle-manipulator systems(UVMSs) have captured researchers’ attention. Inspired by fish, bionic mechanisms were introduced into a *** underwater biomimetic vehicle-manipulator system(UBVMS) is actuated by two symmetrically arranged biomimetic undulatory fin propulsors [1]. Based on the UBVMS, some topics have been researched, such as freefloating autonomous operation [2, 3], three-dimensional helical path following [4], and underwater video processing [5].

关键词： underwater biomimetic vehicle underwater robots underwater vehicle-manipulator system biomimetic robots hydrodynamic modeling

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Design,modeling,and Control of Biomimetic Fish Robot:A Review

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Journal of Bionic Engineering 2019年第6期16卷 967-993页

作者： Palmani Duraisamy Rakesh Kumar Sidharthan Manigandan Nagarajan Santhanakrishnan Robotics Laboratory Department of Electronics and Instrumentation EngineeringSASTRA Deemed UniversityThanjavurTamil Nadu-613401India

A comprehensive review on bio-inspired fish robots has been done in this article with an enhanced focus on swimming styles,actuators,hydrodynamics,kinematic-dynamic modeling,and *** styles such as body and/or caudal fin and median and/or paired fin and their variants are discussed in *** shows that most fish robots adapt carangiform in body and/or caudal fin type swimming as it gives significant thrust with a maximum speed of 3.7 ms 1 in *** of smart or soft actuators to enhance real-time dynamics was studied from literature,and it was found that the robot built with polymer fiber composite material could reach a speed of 0.6 m s However,dynamic modeling is relatively complex,and material selection needs to be *** numerical and analytical methods in dynamic modeling have been investigated highlighting merits and *** parameter estimation through the data-driven model is widely used in offline,however online estimation of the same need to be *** controllers are frequently used tor navigation and stabilization,which often encounters the linearization problem and hence,can be replaced with the state-of-the-art adaptive and intelligent *** article also summarizes the potential research gaps and future scopes.

关键词： biomimetic fish robot swimming modes hydrodynamic modeling motion control smart actuators

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modeling potential scenarios of the Tangjiashan Lake outburst and risk assessment in the downstream valley

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Frontiers of Earth Science 2017年第3期11卷 579-591页

作者： Vera KIDYAEVA Sergey CHERNOMORETS Inna KRYLENKO Fangqiang WEI Dmitry PETRAKOV Pengcheng SU Hongjuan YANG Junnan XIONG Lomonosov Moscow State University Faculty of Geography 119991 Moscow Russia Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China

This research is devoted to Taniashan Lake, a quake landslide-dammed lake, situated in Sichuan Pro- vince, China, which was formed by a landslide triggered by the Wenchuan Earthquake on 12 May 2008. A STREAM_2D two-dimensional hydrodynamic model of Russia was applied to simulate the process of two flood scenarios： 1, lake dam outbreak, and 2, dam overtopping. An artificial dam outbreak was made after the earthquake to lower the water level of the lake in 2008, which led to a great flood with a maximum water discharge of more than 6400 m3/s. The negative impact of the flood was reduced by a timely evacuation of the population. Flood hazards still remain in the event of new landslides into the lake and lake dam overtopping （Scenario 2）, in which case a maximum water discharge at the dam crest would reach 5000 m3/s, placing the population of Shabacun and Shilingzi villages in the zone of flood impact.

关键词： Tangjiashan Lake landslide-dammed lakeoutburst hydrodynamic modeling risk assessment

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On the thrust performance of an ionic polymer-metal composite actuated robotic fish: modeling and experimental investigation

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Science China(Technological Sciences) 2012年第12期55卷 3359-3369页

作者： WANG TianMiao SHEN Qi WEN Li LIANG JianHong Robotic Institute School of Mechanical Engineering and AutomationBeihang UniversityBeijing 100191China Museum of Comparative Biology Harvard University26 Oxford St.CambridgeMA 02138USA

In this paper, we theoretically predict and experimentally measure the thrust efficiency of a biomimetic robotic fish, which is propelled by an ionic polymer-metal composite （IPMC） actuator. A physics-based model that consists of IPMC dynamics and hydrodynamics was proposed, and simulation was conducted. In order to test the thrust performance of the robotic fish, a novel experimental apparatus was developed for hydrodynamic experiments. Under a servo towing system, the IPMC fish swam at a self-propelled speed where external force is averagely zero. Experimental results demonstrated that the theoretical model can well predict the thrust efficiency of the robotic fish. A maximum thrust efficiency of 2.3x10-3 at 1 Hz was recorded experi- mentally, the maximum thrust force was 0.0253 N, recorded at 1.2 Hz, while the maximum speed was 0.021 m/s, recorded at 1.5 Hz, and a peak power of 0.36 W was recorded at 2.6 Hz. Additionally, the optimal actuation frequency for the thrust efficiency was also recorded at the maximum self-propelled speed. The present method of examining the thrust efficiency may also be applied to the studies of other types of smart material actuated underwater robots.

关键词： biomimetic robotic fish hydrodynamic modeling thrust efficiency measurement ionic polymer-metal composites

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Effects of Reducing River Flow on Pulse Residence Time in Little Manatee River,USA

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Transactions of Tianjin University 2009年第2期15卷 95-100页

作者： HUANG Wenrui,LIU Xiaohai(Department of Civil Engineering,Florida State University,Tallahassee,Florida 32310-6046,USA) Department of Civil Engineering Florida State University Tallahassee USA

Residence time is an important indicator for river environmental *** this paper,a 3D hydrodynamic model has been successfully applied to Little Manatee River to characterize the mixing and transport process and residence *** model employs horizontal curvilinear orthogonal grids to represent the complex river system that consists of branches and *** model has been satisfactorily calibrated and verified by using two continuous data *** data sets consist of hourly observations of all forcing boundaries,including freshwater inputs,tides,winds,salinity and temperatures at bay boundary,and air temperatures for model *** data sets also consist of hourly observations of water levels,salinity,and temperature at several river *** calibrated and verified hydrodynamic model was used to predict residence time in the Little Manatee *** the minimum flow of 0.312 m3/s,the pulse residence time(PRT) is 108 *** simulations were also conducted for 17 flow *** regression equations have been satisfactorily derived to correlate PRT to freshwater *** coefficient R2 is 0.982 for PRT.

关键词： hydrodynamic modeling estuary residence time tidal river

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The hydrodynamic Behaviour of Euboean Gulf Coastal Areas and the Mixing of the Physico-Chemical Characteristics of Urban Sewage Discharged into Them under the Influence of Climate Change

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Computational Water, Energy, and Environmental Engineering 2023年第4期12卷 27-57页

作者： Evangelos Tsirogiannis Panagiotis Angelidis Division of Hydraulics Department of Civil Engineering School of Engineering Democritus University of Thrace Kimmeria Campus Xanthi Greece

The hydrodynamic circulation within the marine environment is a complex phenomenon, characterized by the interplay of strong tidal forces, atmospheric influences, and bathymetric features. The physical and hydrodynamic attributes of this flow play a pivotal role in promoting vertical mixing of seawater masses, thereby facilitating the integration of their physical and chemical parameters, including nutrients and oxygen. Additionally, they are instrumental in governing the dispersion and diffusion of pollutants originating from urban sewage, contributing to the overall water renewal process and environmental quality. This study investigates the potential impact of anticipated increases in average air temperatures on water column stratification in coastal regions susceptible to these dynamic influences. These areas receive treated urban sewage, and the study aims to assess how these temperature changes might influence the dispersion and mixing of pollutant loads present in these coastal waters.

关键词： hydrodynamic modeling Climate Change Euboean Gulf Greece Stratification Sewage Mixing Water Quality modeling

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