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World Journal of Gastroenterology 2017年第45期23卷 7989-7999页

作者： Rui-Qing Zhang Xin-Hua Chen Hao Wen Hepatobiliary and hydatid Depart- ment Digestive and Vascular Surgery CentreXinjiang Key Laboratory of EchinococcosisThe First Affiliated Hospital of Xinjiang Medical University Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthThe First Affiliated HospitalZhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious diseases The First Affiliated HospitalZhejiang University

AIM To investigate a safer way to set up the disease model of cystic echinococcosis without contamination risk and develop a novel experimental murine model of hepatic cystic echinococcosis. METHODS C57 B/6 mice were injected with human protoscolices of three different concentrations via the portal vein. The mice were followed for 10 mo by ultrasound,gross anatomy,and pathological and immunological examinations. The protoscolex migration in the portal vein,hydatid cyst growth,host immune reaction,and hepatic histopathology were examined *** The infection rates in the mice in the high,medium,and low concentration groups were 90%,100%,and 63.6%,respectively. The protoscolices migrated in the portal vein with blood flow,settled in the liver,and developed into orthotopic hepatic hydatid cysts,resembling the natural infection route and *** We have established an improved experimental model of hepatic cystic echinococcosis with low biohazard risk but stable growing dynamics and immune reaction. It is especially useful for new anti-parasite medication trials against hydatid disease.

关键词： Echinococcosis Echinococcosis granulosus Protoscolex hydatid disease Experimental model

Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

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World Journal of Gastroenterology 2009年第1期15卷 112-116页

作者： Gokhan Adas Soykan Arikan Ozgur Kemik Ali Oner Nilgun Sahip Oguzhan Karatepe Okmeydani Training Hospital Okmeydani/SisliIstanbul 34715 Turkey

AIM： TO establish which scolicidal agents are superior and more suitable for regular use. METHODS： Echinococcus granu/osus protoscoleces were obtained from 25 patients with liver hydatid cysts. Various concentrations of albendazole sulfone, albendazole sulfoxide, and albendazole sulfone and albendazole sulfoxide mixed together in concentrations of 50 μg/mL, and H202 in a concentration of 4%, NaCI 20%, and 1.5% cetrimide-0.15% chlorhexidine （10% Savlon-Turkey） were used to determine the scolicidal effects. Albendazole （ABZ） derivatives and other scolicidal agents were applied to a minimum of 100 scoleces for 5 and 10 min. The degree of viability was calculated according to the number of living scolices per field from a total of 100 scolices observed under the microscope. RESULTS： After 5 min, ABZ sulfone was 97.3% effective, ABZ sulfoxide was 98.4% effective, and the combined solution was 98.6% effective. When sulfone, sulfoxide and the combined solutions were compared, the combined solution seemed more effective than sulfone. However, there was no difference when the combined solution was compared with sulfoxide. After 10 min, hypertonic salt water, sulfone, sulfoxide, and the combined solution compared to other solutions looked more effective and this was statistically significant on an advanced level. When sulfone, sulfoxide, and the combined solutions were compared with each other, the combined solution appeared more effective than sulfone. When the combined solution was compared with sulfoxide, there was no difference. CONCLUSION： Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment.

关键词： hydatid disease AIbendazole In vitrostudy Combined solution Scolicidal agents

A rare case of renal hydatidosis in a child with congenital solitary kidney

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 671-672页

作者： Livius Tirnea Radu Minciu Tudor Rares Olariu Victor Dumitrascu Adriana Maria Neghina Raul Neghina Victor Babes University of Medicine and Pharmacy 2 Eftimie Murgu Sq 300041 TimisoaraRomania Private Practice 5 Vasile Lucaciu Str. 300051 TimisoaraRomania

hydatid cyst of a solitary congenital kidney is a rare entity because of the small percentage of cases with renal hvdatidosis and the reduced number of cases with this renal *** report a case presenting this extremely rare combination and having a favorable *** diagnosis was confirmed based on an association of iniagistic techniques and positive *** case was managed using a minimal invasive surgical technique(PAIR) that reduced the operative ***,an antihelminthic agent[albendazole) was *** our knowledge,this is the first case with such comorbidity and treated through percutaneous approach.

关键词： hydatid disease Cystic echinococcosis Renal cyst Congenital solitary kidney Child

Intrabiliary rupture of hepatic hydatid cysts： results of 10 years＇ experience

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Chinese Medical Journal 2013年第7期126卷 1384-1385页

作者： Tuerganaili Aji Ayifuhan Ahan SHAO Ying-mei RAN Bo JIANG Tie-ming WEN Hao Department of Hepatic hydatid and Hepatobiliary Surgery Digestive and Vascular Surgery Centre First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830000 China Xinjiang Key Lab of Fundamental Medical Research and Xinjiang hydatid Clinical Research Institute First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830000 China

Intrabiliary rupture （IBR）is the most common and potentially fatal complication of Hepatic cysticechinococcosis （HCE） Early diagnosis and treatment of IBR is very important, since mortality is high when obstructio... 详细信息

关键词： intrabiliary rupture cystic echinococcosis hydatid disease diagnosis treatment

Pericyst: The outermost layer of hydatid cyst

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World Journal of Gastroenterology 2014年第5期20卷 1377-1378页

作者： Samad EJ Golzari Mohsen Sokouti Cardiovascular Research Center Tabriz University of Medical Sciences Department of Cardiothoracic Surgery Tabriz University of Medical Sciences

hydatid disease,caused by the parasite Echinococcus granulosus,mostly affects the liver and the lungs with hydatid cysts which consist of three layers:(1)the outer pericyst;(2)the middle laminated membrane;and(3)the inner germinal ***,as the outermost layer of the hydatid cyst,is made by host cells encasing the hydatid *** extremely close interaction exists between this host tissue and the parasite,and any degenerative changes of the pericyst would result in hydatid cyst degeneration or *** pericyst plays an undeniably important role in the development and survival of the hydatid cyst.

关键词： hydatid disease Echinococcus granulosus hydatid cyst Pericyst Layer

Conquering new battlegrounds:Successful management of isolated giant retrovesical hydatid cyst with robotic assistance

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Asian Journal of Urology 2021年第3期8卷 327-331页

作者： Santosh Kumar Abhishek Chandna Vignesh Manoharan Kalpesh M.Parmar Subhajit Mandal Department of Urology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

hydatid disease(HD)is an accidental human parasitic infestation by cestodes and is most commonly caused by Echinococcus *** happens to be the most common site of involvement,although involvement of other organ symptoms is not *** of the retrovesical pouch by hydatidosis is generally secondary in nature with an incidence of 0.1%-0.5%*** retrovesical hydatid cyst(RVHC)is extremely rare with only few cases in existing *** can present with a wide gamut of symptoms ranging from asymptomatic to obstructive uropathy.A 38-year-old male presented to us with complaints of lower urinary tract symptoms(LUTS)and was found to have an isolated primary retrovesical hydatid cyst on *** RVHC had compressed the right ureter leading to a grossly hydronephrotic non-functional right *** patient was started on albendazole therapy and underwent robot assisted right nephroureterectomy and partial pericystectomy for the *** postoperative period was uneventful with resolution of *** report highlights the various clinical presentations of RVHC as well as the minimal invasive management of this rare entity.

关键词： Retrovesical hydatid cyst Robotic pericystectomy hydatid disease

Multiple recurrent cystic echinococcosis with abdominal aortic involvement: A case report

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World Journal of Clinical Cases 2020年第14期8卷 3108-3113页

作者： Nijiati Taxifulati Xue-An Yang Xin-Feng Zhang Abudusalamu Aini Abuduaini Abulizi Xin Ma Adilai Abulati Fei Wang Ke Xu Tuerganaili Aji Ying-Mei Shao Ayifuhan Ahan Department of Hepatobiliary and hydatid disease Digestive and Vascular CenterFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Pain Management People’s Hospital of Xinjiang Uyghur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina

BACKGROUND Recurrent cystic echinococcosis(CE)with vital organ involvement is a challenge for ***,we report a case of aortic involvement in recurrent retroperitoneal CE lesions following primary splenic CE *** SUMMARY A 60-year-old male was admitted due to progressive abdominal pain and poor *** was diagnosed with multiple recurrent CE with abdominal aortic involvement according to preoperative *** surgical resection,major aortic bleeding accidentally occurred while dissecting the cyst,which was firmly attached to the abdominal aortic *** attempts were conducted to deal with this emergency situation and maintain *** recovery was uneventful,and 2-year follow-up showed no sign of recurrence or any other *** Radical resection of recurrent complicated CE with aortic involvement should be carefully planned and performed to prevent possible severe adverse complications,thereby improving the postoperative outcome.

关键词： Cystic echinococcosis Abdominal aorta Covered vascular stent Patient safety hydatid disease Case report

Spontaneous rupture of a hepatic hydatid cyst into the peritoneum causing only mild abdominal pain:A case report

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World Journal of Gastroenterology 2007年第5期13卷 806-808页

作者： Kemal Karakaya Department of General Surgery Zonguldak Karaelmas University Faculty of Medicine Kozlu Zonguldak 67600 Turkey

hydatid disease is an endemic disease in certain areas of the world. It is located mostly in the liver. Spontaneous rupture of the hydatid cyst into the peritoneum is a rare condition, which is accompanied by serious morbidity and mortality generally. We present herein a case with a spontaneous rupture of a hepatic hidatid disease into the peritoneum without any serious symptoms. A 15-year- old boy was admitted to the emergency room with a mild abdominal pain lasting for a day. Physical examination revealed only mild abdominal tenderness. There was no history of trauma or complaints related to hydatid diseases. Ultrasonography showed a large amount of free fluid and a cystic lesion with irregular borders in the liver. He was operated on. Postoperative albendazol therapy was given for 2 mo. No recurrence or secondary hydatidosis was seen on CT investigation in the 3^th, 6^th and 12^th mo following surgery.

关键词： hydatid disease Spontaneous rupture Liver

Unusual site of recurrent musculoskeletal hydatid cyst: Case report and brief review of the literature

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World Journal of Gastroenterology 2006年第34期12卷 5577-5578页

作者： Panagiotis G Drimousis Konstantinos M Stamou Athanasios Koutras Dimitrios Konstantinos Tsekouras George Zografos 1~(st) Department of Propeudeutic Surgery Hippocrateion Hospital Athens Medical School Athens 11527 Greece

A case of a large multiplex recurrent hydatid cyst involving the left gluteal muscle and the left iliopsoas, accompanied with degeneration of the musculature of the left upper leg is presented along with a review of the relevant literature. Very few such cases have been reported worldwide. The presented case is also distinguished by the involvement of muscles of distant anatomic areas.

关键词： Echinococcosis hydatid disease Musculoskeletal hydatid

Three-dimensional conformal intensity-modulated radiation therapy of left femur foci does not damage the sciatic nerve

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Neural Regeneration Research 2014年第20期9卷 1824-1829页

作者： Wanlong Xu Xibin Zhao Qing Wang Jungang Sun Jiangbo Xu Wenzheng Zhou Hao Wang Shigui Yan Hong Yuan People’s Hospital of Xinjiang Uygur Autonomous Region The Second Affiliated Hospital of Zhejiang University School of Medicine

During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subiected to radio- therapy （40 Gy） for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob- vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echi- nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve.

关键词： nerve regeneration three-dimensional conformal intensity-modulated radiation thera-py hydatid disease sciatic nerve neurons radiation damage succinate dehydrogenase NSFC grants neural regeneration