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Primary Multiple Cerebral hydatid Cyst in 8 Year-Old Girl: A Rare Cause of Childhood Seizure

Open Journal of Modern Neurosurgery 2024年第2期14卷 149-157页

作者： Kaoutar Stitou Ilias Zahir Oualid Mohammed Hmamouche Marouane Hammoud Faycal Lakhdar Mohammed Benzagmout Khalid Chakour Mohammed El Faiz Chaoui Department of Neurosurgery University Hospital of Fez Fez Morocco

Background: Cystic echinococcosis is a zoonotic infection that occurs worldwide. Humans are infected through ingestion of parasite eggs in contaminated food, water or through direct contact with infected dogs, which are the definite host. Humans serve accidentally as intermediate host, and occurrences are common in children and young adults. Cystic echinococcosis is endemic in Mediterranean, South American, Middle Eastern, Central Asia, East Africa countries and Australia. Multiple cerebral hydatid cysts are very rare with only a few reports in the literature. Case Description: We present the case of an 8-year-old girl who presented with focal seizures, hemiparesis, headache, vomiting and bilateral optic atrophy. Diagnostic workup was performed, and magnetic resonance imaging revealed multiple intracranial cysts predominantly in the right frontal region with significant mass effect. A total of 11 intracranial cysts were removed surgically, and the child recovered uneventfully. Conclusion: Neurosurgeons should keep hydatidosis in the list of differentials when evaluating patients with cystic diseases of the brain. Although the removal of such cysts is challenging, outcomes are excellent when cysts are evacuated without rupture and patients show complete resolution of symptoms.

关键词： hydatid cysts Multiple Hydatic cysts Childhood Seizures

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Pericyst may be a new pharmacological and therapeutic target for hydatid disease

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Chinese Medical Journal 2011年第18期124卷 2857-2862页

作者： WU Xiang-wei CHEN Xue-ling ZHANG Shi-jie ZHANG Xi SUN Hong PENG Xin-yu Department of Hepatobiliary Surgery School of Medicine Shihezi University Shihezi Xinjiang 832000 China the First Affiliated Hospital Department of Immunology School of Medicine Shihezi University Shihezi Xinjiang 832000 China Department of Physical Examination School of Medicine Shihezi University Shihezi Xinjiang 832000 China the Key Laboratory of Xinjiang Endemic and Ethnic Diseases School of Medicine Shihezi University Shihezi Xinjiang 832000 China

Background Most hydatid cysts with calcified walls are biologically and clinically silent and inactive. Transforming growth factor-beta 1 （TGF-β1） plays a critical role in the calcification process of cells. The aim of this study was to assess the effect of modulating TGF-β1 signaling on the calcification of hydatid cysts. Methods Pericyst cells isolated from hepatic hydatid cysts were cultured with osteogenic media. These cells were assessed for alkaline phosphatase activity and mineralization capacity using Alizarin Red staining. Cells were also treated with recombinant human TGF-β1 and TGF-β inhibitor, and the expression profiles of osteoblast markers （RUNX2, osterix, and osteocalcin） were analyzed using Western blotting. The effects of inhibiting TGF-β1 signaling on calcification of pericyst walls were assessed using different doses of TGF-β inhibitor for 7 weeks in a preclinical disease model of liver cystic echinococcosis. Results Cells within the pericyst displayed high levels of alkaline phosphatase activity and mineralized nodule formation, as induced by osteogenic media. These activities, as well as expression profiles of osteoblast markers （RUNX2, osterix, and osteocalcin） could be inhibited by addition of recombinant human TGF-β1 （rhTGF-β1） and enhanced by TGF-β inhibitor. In the animal model of cystic echinococcosis, inhibition of TGF-β1 signaling increased calcification of the pericyst wall, which was associated with decreased cyst load index and lower viability of protoscoleces. Conclusions Cells within the pericysts adopt an osteoblast-like phenotype and have osteogenic potential, inhibition of TGF-β1 signaling increases hydatid cyst calcification. Pharmacological modulation of calcification in pericysts may be a new therapeutic target in the treatment of hydatid disease.

关键词： pericyst hydatid cysts transforming growth factor-beta 1 calcification therapy

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